Shared Resource for Disease Model Surgical Critical Care and Data Mangement

疾病模型外科重症监护和数据管理的共享资源

• 批准号: 7794028
• 负责人: HANSELL H STEDMAN
• 金额: $ 48.05万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794028
• 关键词: Address; Anesthesia procedures; Animal Model; Animals; Applications Grants; Back; Cardiology; Cardiopulmonary Bypass; Cardiovascular system; Clinical; Communities; Complex; Congenital Disorders; Critical Care; Data; Data Storage and Retrieval; Disease model; Environment; Equipment; Foundations; Funding; Healthcare; Heart Diseases; Hereditary Disease; Industry; Intervention; Interventional radiology; Magnetic Resonance Imaging; Malignant Neoplasms; Monitor; Operative Surgical Procedures; Patients; Pennsylvania; Physiological; Process; Research; Research Personnel; Resource Sharing; System; Techniques; Time; Translational Research; United States National Institutes of Health; Universities; Veterinary Medicine; animal resource; base; cancer genetics; data management; improved; instrument; medical schools; member; programs; public health relevance

DESCRIPTION (provided by applicant): Several members of the University of Pennsylvania Academic Surgery, Interventional Radiology, and Cardiology communities are addressing critical issues in basic and translational research that necessitate the use of large animal models. Although the interventions are complex and parallel some of the most sophisticated techniques used in the related clinical fields, the emerging, rate-limiting process in this research is the need for an equally sophisticated anesthesia workflow environment. We are specifically requesting the funds to purchase a pair of complementary anesthesia machines with built-in critical care monitoring and data storage/retrieval/analysis function for use with cardiopulmonary bypass in one setting and MRI in the other setting. Both instruments communicate detailed, time-synchronized physiological information with a common integrated data management system. The proposed shared equipment purchase will dramatically accelerate the research programs of numerous NIH, industry, and foundation supported investigators, and has the backing of the Departments of Surgery and the University Lab Animal Resources. Access to the proposed shared resource will also serve to nucleate the academic anesthesia and surgical critical care communities of both the University of Pennsylvania Schools of Medicine and Veterinary Medicine. This will have direct benefit to the University based research programs that seek to improve healthcare for patients with heart disease, cancer, genetic and congenital disorders. PUBLIC HEALTH RELEVANCE: This grant proposal seeks to develop an anesthesia/critical care environment in our shared large animal vivarium, to match the sophistication of our existing translational research program in surgical interventions for cancer, cardiovascular and genetic diseases.

描述（由申请人提供）：宾夕法尼亚大学学术外科、介入放射学和心脏病学社区的几位成员正在解决基础和转化研究中的关键问题，这些问题需要使用大型动物模型。尽管干预措施很复杂，并且与相关临床领域中使用的一些最复杂的技术平行，但本研究中出现的限速过程是需要一个同样复杂的麻醉工作流程环境。我们特别申请资金购买一对具有内置危重监护监测和数据存储/检索/分析功能的辅助麻醉机，用于体外循环和MRI。这两种仪器通过一个共同的集成数据管理系统传递详细的、时间同步的生理信息。提议的共享设备购买将极大地加速众多NIH、工业和基金会支持的研究人员的研究计划，并得到外科部门和大学实验动物资源的支持。获得拟议的共享资源也将有助于宾夕法尼亚大学医学院和兽医学院的学术麻醉和外科重症监护社区。这将直接有利于以大学为基础的研究项目，旨在改善心脏病、癌症、遗传和先天性疾病患者的医疗保健。