Shared Resource for Disease Model Surgical Critical Care and Data Mangement

描述（由申请人提供）：宾夕法尼亚大学学术外科，介入放射学和心脏病学社区的几名成员正在解决基础和转化研究中的关键问题，这些研究需要使用大型动物模型。虽然干预是复杂的，平行的一些最复杂的技术在相关的临床领域中使用，新兴的，限速的过程中，这项研究是一个同样复杂的麻醉工作流程环境的需要。我们特别要求拨款购买一对辅助麻醉机，内置重症监护和数据存储/检索/分析功能，用于心肺分流术和MRI。这两种仪器都可以通过一个通用的集成数据管理系统传输详细的、时间同步的生理信息。拟议的共享设备购买将大大加快许多NIH，行业和基金会支持的研究人员的研究计划，并得到外科部门和大学实验室动物资源的支持。获得拟议的共享资源也将有助于加强宾夕法尼亚大学医学院和兽医学院的学术麻醉和外科重症监护社区。这将直接有利于大学的研究计划，旨在改善心脏病，癌症，遗传和先天性疾病患者的医疗保健。 公共卫生相关性：该拨款提案旨在在我们共享的大型动物饲养场中开发麻醉/重症监护环境，以匹配我们现有的癌症，心血管和遗传疾病手术干预转化研究计划的复杂性。

DESCRIPTION (provided by applicant): Several members of the University of Pennsylvania Academic Surgery, Interventional Radiology, and Cardiology communities are addressing critical issues in basic and translational research that necessitate the use of large animal models. Although the interventions are complex and parallel some of the most sophisticated techniques used in the related clinical fields, the emerging, rate-limiting process in this research is the need for an equally sophisticated anesthesia workflow environment. We are specifically requesting the funds to purchase a pair of complementary anesthesia machines with built-in critical care monitoring and data storage/retrieval/analysis function for use with cardiopulmonary bypass in one setting and MRI in the other setting. Both instruments communicate detailed, time-synchronized physiological information with a common integrated data management system. The proposed shared equipment purchase will dramatically accelerate the research programs of numerous NIH, industry, and foundation supported investigators, and has the backing of the Departments of Surgery and the University Lab Animal Resources. Access to the proposed shared resource will also serve to nucleate the academic anesthesia and surgical critical care communities of both the University of Pennsylvania Schools of Medicine and Veterinary Medicine. This will have direct benefit to the University based research programs that seek to improve healthcare for patients with heart disease, cancer, genetic and congenital disorders. PUBLIC HEALTH RELEVANCE: This grant proposal seeks to develop an anesthesia/critical care environment in our shared large animal vivarium, to match the sophistication of our existing translational research program in surgical interventions for cancer, cardiovascular and genetic diseases.