Training Program in Genome-Environment Interactions in Neonatal Disease

新生儿疾病基因组-环境相互作用培训计划

• 批准号: 7869879
• 负责人: George SCOTT WORTHEN
• 金额: $ 19.37万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-10 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7869879
• 关键词: Disease; Environment; Genome; Neonatal; Training Programs

DESCRIPTION (provided by applicant): Premature birth remains a significant health concern and an increasing proportion of very low birth weight infants are surviving. As a consequence, neonatologists are facing an expanding population of infants with poorly-understood diseases in whom prematurity is a major causative factor. Preterm delivery may expose genetic and epigenetic susceptibility to the extraordinary demands of adaptation to the environment of the nursery. New insights, based on modern genetic analysis are required to address this important problem area. Few physician-scientists or biomedical investigators are trained to understand the complex interplay between genes and environment in the immature host. The overall objective of the proposed Genes and Environment in Neonatal Education (GENE) Training Program is to provide research training for clinical and basic science investigators in the design, implementation and analysis of genome-wide genetic and epigenetic studies in neonates. The program is designed to integrate basic genetic training with research skills fundamental to the unique demands of genome-wide investigation. Using a two-mentor model in which a genetics or epigenetics mentor assists the trainee in understanding the application of modern state-of-the- art tools, while a mentor focused on biological problems in the neonate guides the trainee through clinical or developmental analyses specifically geared to understanding diseases in the NICU. A team of experts in genetics, epigenetics, and clinical/translational research has been assembled to facilitate this training effort. These mentors, combined with the outstanding clinical facilities and research cores of the Children's Hospital of Philadelphia, the University of Pennsylvania, the and the Stokes Research Institute will enhance the training experience of MD and PhD post-doctoral fellows and prepare them to become experts in this emerging field of research. PUBLIC HEALTH RELEVANCE: An increasing number of very premature infants are surviving with complex medical problems, reflecting the influence of environmental factors such as prematurity itself or transition to breathing and feeding on a genetically-susceptible neonate. Few scientists are trained to understand the interactions between genes and the unique environment of the premature infant. This training program attempts to correct that deficiency.

描述（由申请人提供）：早产仍然是一个重大的健康问题，并且极低出生体重婴儿的存活率越来越高。因此，新生儿科医生面临着越来越多的婴儿患有我们知之甚少的疾病，而早产是这些疾病的主要致病因素。早产可能会暴露遗传和表观遗传的易感性，以适应托儿所环境的特殊要求。解决这一重要问题领域需要基于现代遗传分析的新见解。很少有医生科学家或生物医学研究人员接受过培训来了解未成熟宿主中基因与环境之间复杂的相互作用。拟议的新生儿教育基因与环境（GENE）培训计划的总体目标是为临床和基础科学研究人员提供设计、实施和分析新生儿全基因组遗传和表观遗传学研究的研究培训。该计划旨在将基本遗传培训与研究技能相结合，以满足全基因组研究的独特需求。采用两位导师模式，其中遗传学或表观遗传学导师帮助受训者了解现代最先进工具的应用，而专注于新生儿生物学问题的导师则指导受训者进行专门用于了解 NICU 疾病的临床或发育分析。遗传学、表观遗传学和临床/转化研究方面的专家团队已经组建起来，以促进这项培训工作。这些导师与费城儿童医院、宾夕法尼亚大学、斯托克斯研究所的优秀临床设施和研究核心相结合，将增强医学博士和博士后研究员的培训经验，并帮助他们成为这一新兴研究领域的专家。 公共健康相关性：越来越多的早产儿面临着复杂的医疗问题，这反映出环境因素的影响，例如早产本身或遗传易感新生儿的呼吸和喂养过渡。很少有科学家受过训练来了解基因与早产儿独特环境之间的相互作用。该培训计划试图纠正这一缺陷。