The UTSW Small Animal SPECT-CT for Molecular Imaging Research and Education

用于分子影像研究和教育的 UTSW 小动物 SPECT-CT

• 批准号: 7843162
• 负责人: Orhan Kemal Oz
• 金额: $ 89.41万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-08 至 2011-07-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7843162
• 关键词: American; Animal Model; Animals; Area; Arthritis; Autoimmunity; Biology; Cardiovascular system; Disease; Disease Progression; Education; Funding; Grant; Healthcare; Image; Lead; Lupus; Manufacturer Name; Modeling; Molecular; Monitor; Mus; Neurobiology; Occupations; Pathogenesis; Photons; Plants; Price; Radiochemistry; Rattus; Research; Research Personnel; Resolution; Scanning; Scientist; Site; Site Visit; Treatment Efficacy; United States National Institutes of Health; Validation; Vendor; base; human disease; improved; in vivo; molecular imaging; neuro-oncology; next generation; oncology; programs; public health relevance; radiologist; radiotracer; virtual

DESCRIPTION (provided by applicant):: The objective of this application is the purchase of a BioScan NanoSPECT-CT scanner for in vivo small animal scanning. The requested purchase price is $1,063,916. Acquisition of the scanner will fulfill an unmet campus- wide need: high resolution small animal imaging in mice and rats injected with single photon emitting radiotracers. The scanner will permit a distinguished group of 13 NIH funded scientists to more optimally use animal models that have been created over years. A total of 21 NIH grants are supported in areas of neurobiology and neuro-oncology, cardiovascular biology and disease, arthritis, autoimmunity (lupus), oncology, and radiochemistry. Furthermore, we envisage a program in which the scanner will partially fulfill the educational imaging needs of the next generation molecular imagers and radiologists. The scanner was chosen after receiving quotes from the manufacturers. A team of 3 scientists, comprised of the PI (Radiologist- scientist), physicist, and a radiochemist, was formed to primarily evaluate the available commercial scanners. Site visits to installation sites, manufacturer's plants, or virtual demos were conducted for each of the major vendors. Scanner resolution, sensitivity, installed base, and ease of use were the dominant factors after considering the needs of the major users. The BioScan NanoSPECT-CT was considered the best choice for our users. Purchase of the scanner will lead to an immediate creation of 2 new jobs at UT Southwestern. Once investigators successfully use the scanner it is likely new funding will result that might lead to other jobs. The understanding that will result from application of SPECT/CT imaging of models of human disease may potentially lead to new therapies and improved healthcare for the American people. PUBLIC HEALTH RELEVANCE: Small animal models of human diseases are important for advancing understanding of disease pathogenesis and disease treatment. Imaging studies in these animal models are critical for model validation, to follow disease progression, to monitor therapy efficacy, and minimize animal use. Purchasing the scanner will enhance research in these areas, potentially improve healthcare, and lead to creation of two jobs.

描述（由申请人提供）：：本申请的目的是购买用于体内小动物扫描的BioScan NanoSPECT-CT扫描仪。请购价格为1 063 916美元。该扫描仪的采购将满足未满足的校园范围内的需求：高分辨率的小动物成像的小鼠和大鼠注射单光子发射放射性示踪剂。该扫描仪将允许一个由13名NIH资助的科学家组成的杰出小组更好地使用多年来创建的动物模型。在神经生物学和神经肿瘤学、心血管生物学和疾病、关节炎、自身免疫（狼疮）、肿瘤学和放射化学领域，共有21项NIH赠款得到支持。此外，我们设想了一个计划，其中扫描仪将部分满足下一代分子成像仪和放射科医生的教育成像需求。扫描仪是在收到制造商的报价后选择的。由PI（放射科医生-科学家）、物理学家和放射化学家组成的3名科学家团队主要评价可用的市售扫描仪。对每个主要供应商的安装现场、制造商工厂或虚拟演示进行了现场访问。在考虑了主要用户的需求之后，扫描仪的分辨率、灵敏度、安装基础和易用性是主要因素。BioScan NanoSPECT-CT被认为是我们用户的最佳选择。购买扫描仪将导致立即创造2个新的就业机会在UT西南。一旦调查人员成功使用扫描仪，很可能会产生新的资金，可能会导致其他工作。对人类疾病模型的SPECT/CT成像的应用所产生的理解可能会为美国人民带来新的治疗方法和改善的医疗保健。 公共卫生关系：人类疾病的小动物模型对于促进疾病发病机制和疾病治疗的理解是重要的。这些动物模型中的成像研究对于模型验证、跟踪疾病进展、监测治疗疗效和最大限度地减少动物使用至关重要。购买扫描仪将加强这些领域的研究，可能改善医疗保健，并创造两个就业机会。

项目成果

Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts.

Bavituximab（一种具有血管靶向和免疫调节特性的磷脂酰丝氨酸靶向单克隆抗体）在肺癌异种移植物中的肿瘤特异性靶向。

• 发表时间: 2015
• 期刊: American journal of nuclear medicine and molecular imaging
• 影响因子: 2.5
• 作者: Gerber,DavidE;Hao,Guiyang;Watkins,Linda;Stafford,JasonH;Anderson,Jon;Holbein,Blair;Öz,OrhanK;Mathews,Dana;Thorpe,PhilipE;Hassan,Gedaa;Kumar,Amit;Brekken,RolfA;Sun,Xiankai
• 通讯作者: Sun,Xiankai

Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics.

• DOI: 10.1002/anie.201203031
• 发表时间: 2012-10
• 期刊: Angewandte Chemie
• 作者: Chen Zhou;G. Hao;P. Thomas;Jinbin Liu;Mengxiao Yu;Shasha Sun;Orhan K Öz;Xiankai Sun;Jie Zheng-Jie-Zh

A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P.

寻骨剂 DO2A2P 反式和顺式异构体的比较研究。

• DOI: 10.1016/j.bmcl.2014.12.016
• 发表时间: 2015
• 期刊: Bioorganic & medicinal chemistry letters
• 影响因子: 2.7
• 作者: Hao,Guiyang;Liu,Wei;Hassan,Gedaa;Öz,OrhanK;Kovacs,Zoltan;Sun,Xiankai
• 通讯作者: Sun,Xiankai

Copper-67 radioimmunotheranostics for simultaneous immunotherapy and immuno-SPECT.

• DOI: 10.1038/s41598-021-82812-1
• 发表时间: 2021-02-11
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Hao G;Mastren T;Silvers W;Hassan G;Öz OK;Sun X
• 通讯作者: Sun X