An Interdisciplinary Molecular Metabolism Training Program

跨学科分子代谢培训计划

• 批准号: 7869732
• 负责人: Christopher J Rhodes
• 金额: $ 13.35万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7869732
• 关键词: Metabolism; Molecular; Training Programs

DESCRIPTION (provided by applicant): Metabolic disease is a massive worldwide health problem as illustrated by the current epidemics in obesity and type 2 diabetes, which is especially prominent in the United States and showing no sign of abating. As such, there is an urgent need for metabolism research to face this alarming situation. However, there are relatively few training programs across the country specifically dedicated to the training of bright young researchers in metabolism at the systemic, cellular and molecular level. To address this need we have set up the Molecular Metabolism Training Program (MMTP) at the University of Chicago which incorporates the Committee on Molecular Metabolism & Nutrition (CMMN) that is one of the few, perhaps the only, graduate programs in the United States granting a PhD in molecular metabolism. A successful training program in metabolism requires a multi- and inter-disciplinary approach, made up of researchers with a wide variety of technical skills and research experience. The MMTP takes advantage of the marvelous and highly interactive biomedical environment and strong traditions in metabolic and diabetes research at the University of Chicago. The trainers in the MMTP, in whose laboratories MMTP trainees will conduct their research projects, have primary appointments across many departments and sections of the Biological Sciences Division, to cover most of the diversity in metabolism research. Being interdepartmental, the MMTP pre- and postdoctoral trainees can take courses and gain experience in Biochemistry, Molecular Biology, Cell Biology, Genetics, Medicine, Pathology, Immunology, Physiology and Neurobiology with a required comprehensive specialized metabolism core-curriculum. Trainees are also required to attend metabolism journal clubs, data sessions, seminar series, and an annual retreat. Participation in National and International metabolism, diabetes and/or obesity scientific meetings is expected. There is strong institutional support, as well as a significant allocation of new research space and equipment for this fast growing MMTP. Many outstanding applicants apply to the MMTP and the recruitment success rate is very high. Pre-doctoral trainees recently graduated from the CMMN/MMTP have found postdoctoral positions in outstanding academic metabolism research laboratories. Although newly established, the ultimate goal of the MMTP is to set up young researchers on the path to become independent academic metabolism research scientists and mentors themselves - dedicated to excellent scholarship and making breakthrough discoveries in metabolic disease and diabetes/obesity research that will lead to new therapies to better treat, prevent and perhaps even cure these disorders. PUBLIC HEALTH RELEVANCE: Metabolism is required for life and impinges on almost every disease state, but despite this fact, as well as a resurgent interest for metabolic disease research (partly driven by worrisome epidemics in obesity and diabetes), there are insufficient specialized basic/translational researchers to tackle these huge metabolic health problems. The newly established MMTP at the University of Chicago has clear relevance to produce much needed, highly qualified and experienced young researchers specialized in molecular metabolism to make new discoveries that in turn benefit the many who suffer from metabolic diseases like diabetes/obesity.

描述（由申请人提供）：代谢性疾病是一个巨大的全球性健康问题，如目前肥胖和2型糖尿病的流行所示，这在美国尤其突出，并且没有减弱的迹象。因此，迫切需要代谢研究来面对这一令人担忧的情况。然而，在全国范围内，专门致力于在系统，细胞和分子水平上培养年轻的代谢研究人员的培训计划相对较少。为了满足这一需求，我们在芝加哥大学设立了分子代谢培训项目（MMTP），该项目纳入了分子代谢与营养委员会（CMMN），这是美国为数不多的，也许是唯一的授予分子代谢博士学位的研究生项目。 一个成功的新陈代谢培训计划需要多学科和跨学科的方法，由具有各种技术技能和研究经验的研究人员组成。MMTP利用了芝加哥大学在代谢和糖尿病研究方面的非凡和高度互动的生物医学环境和强大的传统。MMTP的培训师，在其实验室MMTP学员将进行他们的研究项目，在生物科学司的许多部门和部门的主要任命，以涵盖代谢研究的大部分多样性。作为跨部门，MMTP的前和博士后学员可以参加课程，并获得经验，生物化学，分子生物学，细胞生物学，遗传学，医学，病理学，免疫学，生理学和神经生物学与所需的全面专业代谢核心课程。学员还需要参加新陈代谢杂志俱乐部，数据会议，系列研讨会和年度务虚会。预计将参加国家和国际代谢、糖尿病和/或肥胖科学会议。有强大的机构支持，以及一个新的研究空间和设备的重要分配这个快速增长的MMTP。许多优秀的申请人申请MMTP，招聘成功率非常高。最近从CMMN/MMTP毕业的博士前实习生在优秀的学术代谢研究实验室找到了博士后职位。虽然是新成立的，但MMTP的最终目标是让年轻的研究人员走上成为独立学术代谢研究科学家和导师的道路-致力于优秀的学术研究，并在代谢疾病和糖尿病/肥胖研究方面取得突破性发现，这将导致新的疗法，以更好地治疗，预防甚至治愈这些疾病。 公共卫生关系：代谢是生命所必需的，几乎影响到每一种疾病状态，但尽管如此，以及对代谢性疾病研究的重新关注（部分原因是肥胖和糖尿病令人担忧的流行病），没有足够的专业基础/转化研究人员来解决这些巨大的代谢健康问题。新成立的MMTP在芝加哥大学有明确的相关性，以产生急需的，高素质和经验丰富的年轻研究人员专门从事分子代谢，使新的发现，反过来有利于许多谁患有代谢疾病，如糖尿病/肥胖症。