PET/CT Imaging System

描述(由申请人提供)：本申请要求为加州大学伯克利分校(UCB)、劳伦斯·伯克利国家实验室(LBNL)、加州大学旧金山分校和加州大学戴维斯分校的一组研究人员提供PET/CT成像系统。10个主要用户由10个R01、2个P01以及用于PET研究的NIH、联邦和基金会的可观额外拨款支持。该小组多年来一直使用现有的LBNL研究专用PET相机，并在资金、运营、数据分析和对象运输方面进行了合作。然而，目前的摄像头已经过时，不再受制造商的支持，而且由于故障和难以获得部件而频繁且长时间的停机。这是对现代相机的要求，它将支持神经科学研究的主要应用以及多种其他应用。扫描仪被配置为提供最佳的图像采集和研究灵活性，但没有昂贵的临床选择，这对于研究计划来说是不必要的。环境很好，现有的补充设备包括LBNL的1.5T磁共振系统和SPECT/CT系统，以及UCB园区的3T磁共振系统。LBNL的一台医用回旋加速器由一个放射化学研究小组运营，生产各种人类和动物使用的放射性药物。该研究小组在PET和成像技术方面也有着悠久的卓越历史，并在原型PET相机的设计、建造、运营和维护以及PET数据分析方面拥有丰富的经验。该仪器的使用将由一个业务小组监督，该小组由技术人员和科学家组成，他们是软件支持/数据分析、放射化学和硬件支持方面的专家。该小组将操作扫描仪，提供质量控制，监测使用情况，并确保培训所有用户以及遵守人类、动物和放射性同位素法规。用户组将协助制定协议，并提供操作组和用户之间的接口。该机构(LBNL)已承诺为票据选址方面的任何必要翻新提供支持，并将运营一个财务管理充值设施。目前的使用量足以支持运营成本、服务合同和最低限度的人员配备，每小时收费相对较低。整个项目将由一个执行委员会监督，该执行委员会负责确保进入、促进工具的使用、管理冲突、确保培训和产生持续的外部支持。 与公共健康相关：正电子发射断层扫描(PET)成像已经达到了成熟的水平，可以研究与人类健康相关的一系列生化过程，并可能揭示人类疾病的基本过程。这款PET扫描仪将允许一组研究人员继续他们的生产性研究，并将通过在美国继续制造扫描仪以及开发和支持雇用技术和科学工作者的科学基础设施来帮助创造就业机会。

DESCRIPTION (provided by applicant): This application requests a PET/CT imaging system for a group of investigators at the University of California Berkeley (UCB), Lawrence Berkeley National Laboratory (LBNL), University of California San Francisco and the University of California Davis. Ten major users are supported by 10 R01s, 2 P01s and considerable additional NIH, federal and foundation grants for PET research. The group has used the existing LBNL research-dedicated PET camera for years, and has collaborated on issues related to funding, operations, data analysis, and subject transportation. However, the current camera is outdated, no longer supported by the manufacturer, and suffers from frequent and prolonged downtime related to failures and difficulty obtaining parts. The request is for a modern camera that will support both the primary application of neuroscience research as well as multiple other applications. The scanner is configured to provide optimal image acquisition and research flexibility but without expensive clinical options that are unnecessary for the research program. The environment is strong, with existing complementary equipment including a 1.5T MR system and a SPECT/CT system at LBNL and a 3T MR system on the UCB campus. A medical cyclotron at LBNL operated by a radiochemistry research group, produces a wide variety of radiopharmaceuticals for human and animal use. The research group also has a long history of excellence in PET and imaging technology and has experience with the design, construction, operation, and maintenance of prototype PET cameras as well as PET data analysis. Use of the instrument will be overseen by an operations group comprised of technical staff and scientists who are expert in software support/data analysis, radiochemistry and hardware support. This group will operate the scanner, provide quality control, monitor usage, and assure training of all users as well as compliance with human, animal, and radioisotope regulations. A users group will assist in the development of protocols and will provide the interface between the operations group and users. The institution (LBNL) has committed support for any necessary renovations in siting the instrument, and will operate a recharge facility for financial administration. Current usage is adequate to support the cost of operations, a service contract, and minimal staffing with a relatively modest hourly charge. The entire project will be overseen by an executive committee with responsibility for ensuring access, promoting the use of the instrument, managing conflicts, ensuring training, and generation of continued extramural support. PUBLIC HEALTH RELEVANCE: Imaging with positron emission tomography (PET) has reached a level of maturity that permits the investigation of a host of biochemical processes that are related to human health and may reveal the fundamental processes underlying human disease. This PET scanner will permit a group of investigators to continue their productive research, and will help to create jobs through the continuing manufacture of scanners in the US as well as the development and support of a scientific infrastructure that employs technical and scientific workers.