The Cellular Biophysics of the Neuron Training Program

描述(由申请人提供)：德克萨斯大学达拉斯西南医学中心的神经元细胞生物物理学培训计划(CBNTP)将培养学员成为杰出的生物物理学家，使用定量方法和先进的分析工具解决复杂的神经科学问题。这一领域的革命性发现将来自科学家，他们将对生物物理原理的深刻理解和对光学和电生理工具的透彻理解与对神经科学研究中的问题的深入了解相结合。该计划的中心目标是培养能够在细胞生物物理学家和专注于复杂神经科学问题(包括神经学、神经发育和神经精神障碍的细胞/分子基础)之间协同作用的科学家。CBNTP教职员工在他们的研究中使用了广泛的生物物理学方法，强调与人类健康、生理学和疾病的相关性。CBNTP中的科学机会，从对不同模型系统中神经元功能的机械分析，到对非神经元细胞系统中与神经元相关的过程的详细生物物理研究，将为培训提供独特的特殊前景。学员将在实验生物物理学原理方面获得最先进的专业知识，并从深入接触这些原理如何应用于高级神经科学研究中受益。学生将接受严格的膜生物物理学、定量分析和细胞神经生理学方面的正式培训。此外，他们将指导与已建立的世界级榜样的互动，并从机构内外的丰富活动中受益。学生将在第三年的秋季加入CBNTP，并作为实习生持续两年。实习生的选择是竞争激烈的。计划指导委员会将根据学生和导师的先前资历、当前表现和承诺来选择受训人员，以追求与计划研究目标一致的培训。我们要求在第一年提供2个职位，在第二年及之后的5年内每年提供4个职位。 相关性：先进生物物理方法的爆炸性增长现在影响到几乎每一个 神经科学研究的维度。通过利用定量分子和细胞生物物理学家与专注于神经、神经发育和神经精神疾病的神经科学家和从事模型系统工作的科学家之间的互动，这一独特的培训计划为学生配备了神经科学研究领域的科学领先者所需的复杂技能。

DESCRIPTION (provided by applicant): The Cellular Biophysics ofthe Neuron Training Program (CBNTP) at the University ofTexas Southwestern Medical Center at Dallas (UTSW) will prepare trainees to become exceptional biophysical scientists addressing complex neuroscience questions using quantitative methods and advanced analytical tools. Transformative discoveries in this field will come from scientists who combine a deep appreciation of biophysical principles and thorough understanding of optical and electrophysiological tools with an intimate knowledge of problems in neuroscience research. The program's central goal is to train scientists who can cultivate synergistic interactions between cellular biophysicts and scientists focused on complex neuroscience problems including cellular/molecular basis of neurological, neurodevelopmental and neuropsychiatric disorders. CBNTP faculty members employ a wide range of biophysical methodologies in their research, emphasizing relevance to human health, physiology and disease. Scientific opportunities in the CBNTP ranging from mechanistic analyses of neuronal function in diverse model systems to detailed biophysical studies of neuron-relevant processes in non- neuronal cellular systems will offer uniquely exceptional prospects for training. Trainees will gain state-of-the- art expertise in experimental biophysical principals and benefit from intimate exposure to how these principles are applied in advanced neuroscience research. Students will receive rigorous formal training in membrane biophysics, quantitative analyses and cellular neurophysiology. Additionally, they will have guided interactions with established, world class role models and benefit from enrichment activities inside and outside of the institution. Students will join the CBNTP in the fall of their third year and remain as trainees for two years. Trainee selection is competitive. The program steering committee will select trainees based on prior credentials, current performance and commitment ofthe student and mentor to pursue training consistent with research goals of the program. We are requesting 2 positions in the first year, a total of 4 positions in the second and for each subsequent year of this 5-year period. RELEVANCE: Explosive growth of advanced biophysical methods now impacts almost every dimension of neuroscience research. By leveraging interactions between quantitative molecular & cellular biophysicts with neuroscientists focused on neurological, neurodevelopmental and neuropsychiatric diseases and those working on model systems, this unique training program equips students with the sophisticated skill sets needed among scientific leaders in neuroscience research.