Next-generation smart wound dressings for real-time, non-invasive monitoring of infection and neovascularisation in burns

下一代智能伤口敷料，用于实时、非侵入性监测烧伤感染和新生血管形成

• 批准号: nhmrc : 2002254
• 金额: $ 89.99万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/next-generation-smart-neovascularisation-burns/1779876
• 关键词: Next; generation; smart; wound; dressings

Real-time assessment of infection and wound progression in burns is critical to reduce complications and improve long-term recovery. We propose a smart dressing that can assess a wound without needing to remove the dressing. It consists of a biocompatible silk membrane enriched with nanodiamonds and pH-sensitive fluorophores to detect infection, and allow optical assessment of blood vessel regrowth. This project will prototype and validate the smart dressing in preparation for human trials.

烧伤感染和伤口进展的实时评估是减少并发症和提高长期恢复的关键。我们提出了一种智能敷料，可以评估伤口而无需移除敷料。它由富含纳米金刚石的生物相容性丝膜和ph敏感荧光团组成，用于检测感染，并允许对血管再生进行光学评估。该项目将制作原型并验证智能敷料，为人体试验做准备。