MODULATING FLUID THERAPY WITH ADRENERGIC AGENTS AND CYCLIC AMP ENHANCERS IN

使用肾上腺素能药物和环放大器增强剂调节液体治疗

• 批准号: 7719194
• 负责人: Michael P Kinsky
• 金额: $ 6.23万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719194
• 关键词: Adrenergic Agents; Adrenergic beta-Antagonists; Affect; Age; Agonist; Blood; Blood Pressure; Blood specimen; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Enhancers; Enrollment; Fluid Therapy; Funding; Grant; Heart; IV Fluid; Institution; Leg; Liquid substance; Measurement; Medicine; Milrinone; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Procedures; Research; Research Personnel; Resources; Saline; Series; Solutions; Source; Standards of Weights and Measures; Testing; Time; Tissues; United States National Institutes of Health; base; beta adrenergic agent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During and after surgery it is a standard procedure to administer intravenous fluid therapy to replace blood and fluid losses. Fluids normally given are saline-based solutions. These solutions distribute into the blood and tissues of the body. We suggest that certain medicines affect the distribution of intravenous fluid therapy. The specific aims of this project are to find out what makes fluid to move out from the blood into the tissues and how medicines (beta-adrenergic agents) may affect this. We will test the effect of intravenous fluid given over a short period of time. We want to know how much of the fluid stays in the blood and how much fluid goes into the tissues. In order to do this study, a series of blood samples and measurements are needed from the leg. One part of this study is to study how fluids distribute in a normal state. Another part of this study is to see if distribution of fluid changes when patients are given medications called beta-blocker or drugs that increase blood pressure (norepineprine) or drugs that increase heart strength (beta-agonists and milrinone). We will enroll only healthy people between the ages of 18 and 50 years. As determined by a statistician, a total of 112 studies will be needed. The results will 1) promote a better understanding of fluid therapy 2)help understand how certain medicines impact fluid therapy 3) help develop a better fluid therapy plan that may decrease illness and death.

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在手术期间和手术后，进行静脉输液治疗以补充血液和液体损失是标准程序。通常给予的液体是生理盐水溶液。这些溶液分布到身体的血液和组织中。 我们认为，某些药物影响静脉输液治疗的分布。 该项目的具体目标是找出是什么使液体从血液中进入组织，以及药物（β-肾上腺素能药物）如何影响这一点。 我们将测试在短时间内静脉输液的效果。我们想知道有多少液体留在血液中，有多少液体进入组织。为了进行这项研究，需要从腿部采集一系列血液样本和测量结果。这项研究的一部分是研究液体在正常状态下是如何分布的。这项研究的另一部分是观察当患者服用β受体阻滞剂或增加血压的药物（去甲肾上腺素）或增加心力的药物（β受体激动剂和米力农）时，液体分布是否发生变化。我们将只招募18至50岁的健康人群。根据统计学家的确定，总共需要112项研究。 结果将1）促进对液体治疗的更好理解2）帮助了解某些药物如何影响液体治疗3）帮助制定更好的液体治疗计划，从而减少疾病和死亡。