NEURAL SUBSTRATES OF EMOTION REGULATION IN HEALTHY INDIVIDUALS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该GCRC申请要求对15名健康志愿者进行MRI扫描和心理生理测试，以扩展我们目前资助的R 01情绪神经回路研究。 我们目前资助的R 01研究使用功能性磁共振成像（fMRI）和心理生理学测量检查了健康对照组和人格障碍（边缘型人格障碍和典型型人格障碍）患者的情绪回路。R 01中的行为任务涉及在没有警告提示的情况下检测和评估三种类型的刺激（不愉快，中性，愉快的图片）。然而，情绪处理还涉及随后的情感反应的调节（菲利普斯等人，2003）。 这项GCRC试点研究将建立在我们目前的被动情绪范式，通过检查15个健康个体的情绪主动调节。我们建议使用一个组合的功能磁共振成像和心理生理学的方法，这是我们正在进行的R 01情绪研究的修改，在这两个功能磁共振成像和心理生理学会议现在将包括线索警告试验的3个条件（中性，不愉快，愉快）和无线索（即没有警告）的试验。 此外，提示/未提示的范例对于两个会话几乎是相同的。不同之处在于，不同的一组图片（在效价和唤醒水平上匹配）将用于两个会话，以最大限度地减少对刺激的习惯化效应。此外，面部肌电图不能记录在磁铁，所以它只会在心理生理会议期间进行测量。这将有助于我们开始探索健康个体在积极调节情绪时是否发生神经回路的变化。我们计划将我们的R 01数据与GCRC项目收集的试验数据一起用于出版物，以及R 01延续应用。 假设： 基于认知控制和情绪处理的一般工作，我们预测，在线索不愉快的试验，抑制负面情绪将增强离散皮层结构（ACC，DLPFC）内的活动和减弱皮层下边缘结构（杏仁核）的活动。也就是说，与无线索-不愉快试验相比，在线索-不愉快试验中，ACC和DLPFC的激活程度更高，并且在愉快或中性条件下，没有线索-无线索差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This GCRC application requests support for MRI scans and psychophysiological testing on 15 healthy volunteers to extend our currently funded R01 study of the neural circuitry of emotion. Our currently funded R01 study examines the circuitry of emotion using functional MRI (fMRI) and psychophysiological measures in healthy controls and individuals with personality disorder (borderline personality disorder and schizotypal personality disorder). The behavioral task in our R01 involves detection and evaluation of three types of stimuli (unpleasant, neutral, pleasant pictures) without a warning cue. However, emotion processing also involves the regulation of the subsequent affective response (Phillips et al 2003). This GCRC pilot study will build on our current passive emotion paradigm by examining active regulation of emotion in 15 healthy individuals. We propose to use a combined fMRI and psychophysiological approach which is a modification of our ongoing R01 study of emotion in that both the fMRI and psychophysiology sessions will now include cued-warning trials for the 3 conditions (neutral, unpleasant, pleasant) and uncued (i.e. no warning) trials. In addition, the cued/uncued paradigm is nearly identical for both sessions. Differences are that a different set of pictures (matched on valence and arousal levels) will be used for the two sessions to minimize habituation effects to the stimuli. Also, facial EMG cannot be recorded in the magnet so it will only be measured during the psychophysiological session. This will help us begin to explore whether neural circuitry changes occur during active regulation of emotion in healthy individuals. We plan to use our R01 data together with the pilot data collected with this GCRC project for publications, as well as, an R01 continuation application. Hypothesis: Based on prior work on cognitive control and emotion processing in general, we predict that on the cued-unpleasant trials, the inhibition of negative emotion will enhance activity within discrete cortical structures (ACC, DLPFC) and attenuate activity in subcortical limbic structures (amygdala). That is, greater activation of ACC and DLPFC will occur during cued-unpleasant trials compared with the uncued-unpleasant trials and there will be no cued-uncued difference for pleasant or neutral conditions.