SLEEP DEPRIVATION AND FMRI

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study applies state-of-the-art advanced functional magnetic resonance imaging (fMRI) methods to map and quantify the neural correlates of impaired performance on executive function and vigilance tasks after sleep deprivation. Specific Aim 1: To use functional magnetic resonance imaging (fMRI) to examine the effects of 24 hours of sleep deprivation on neural networks during executive function (Stroop) and vigilance (auditory odd-ball) tasks in normal controls. Specific Aim 2: To measure changes in fMRI activation patterns before and after sleep deprivation in patients with obstructive sleep apnea (OSA) as outlined in Specific Aim 1. We will compare these results to those obtained in normal controls. Hypothesis 2: Activation patterns on tests of executive function and vigilance in sleep-deprived OSA patients will increase over baseline. We predict, however, that the increase in activation will be smaller than in normal controls reflecting a reduced compensatory reserve.