Developmental Research Program (DRP)

SUMMARY：发展研究计划(DRP) 发展研究方案的具体目标是： 1)宣传试点转化性脑瘤研究项目的启动资金 广泛的可用媒体资源。 2)通过这一机制确定对改善大脑有重大潜力的创新项目 肿瘤治疗和预后，包括通过更好地了解这种疾病的生物学。 3)促进孢子调查人员之间以及与其他调查人员的合作努力，以鼓励 发展新的和创新的理念。 4)加强孢子领导人与外部调查人员之间的沟通，以鼓励 脑肿瘤的创新翻译策略的发展。 5)确保方案的灵活性，以便显示出希望的发展项目可以：a)为 第二年或第三年；b)鼓励申请外部同行审查资金；c)扩大到 成为完整的孢子项目。 脑癌孢子已经建立了明确的指导方针和程序，用于征集、选择和 监测发展研究奖，包括通过以下方式选择和资助的具体标准 同行审查机制，以及密切监测孢子和孢子之间合作的机制 领导和项目获奖者，以提高翻译研究目标的质量。在上一笔资金中 在此期间，我们发起了新想法的支持，并招募了新的研究人员来研究脑瘤，资助了31 奖项，其中两个奖项为重新提交申请的项目做出了贡献。所取得的进展 DRP的研究人员证明，在MDACC脑癌中实施的这一计划是成功的 孢子，包括自然细胞生物学、细胞、癌症细胞和癌症研究的出版物，以及 获得额外的NIH和其他与DRP项目直接相关的资金。DRP已经成为一种 新概念的孵化器和我们脑癌孢子的基石。

SUMMMARY: DEVELOPMENTAL RESEARCH PROGRAM (DRP) The specific aims of the Developmental Research Program are to: 1) Publicize the availability of start-up funds for pilot translational brain tumor research projects across a broad spectrum of available media sources. 2) Identify through this mechanism innovative projects that have significant potential for improving brain tumor therapy and prognosis, including through better understanding the biology of this disease. 3) Foster collaborative efforts among SPORE investigators and with other investigators to encourage the development of new and innovative ideas. 4) Enhance communications between SPORE leaders and outside investigators to encourage the development of innovative translational strategies in brain tumors. 5) Ensure program flexibility so that developmental projects that show promise can be: a) funded for a second or third year; b) encouraged to apply for extramural peer-reviewed funding c) expanded to become full SPORE projects. The Brain Cancer SPORE has established clear guidelines and processes for solicitation, selection, and monitoring of the Developmental Research Awards, including specific criteria for selection and funding through a peer review mechanism, and mechanisms for close monitoring of, and collaboration between the SPORE leaders and program awardees to enhance the quality of the translational research goals. In the last funding period, we initiated support of new ideas and recruited new investigators to study brain tumors, funding 31 awards, two of which contributed to the Projects of this resubmission application. The advances made by investigators in the DRP testify to the success of this program as implemented in this MDACC Brain Cancer SPORE, including publications in Nature Cell Biology, Cell, Cancer Cell, and Cancer Research, and the acquisition of additional NIH and other funding directly related to DRP projects. The DRP has become an incubator of new concepts and a cornerstone of our Brain cancer SPORE.