Developmental Research Program (DRP)

摘要：药物研究计划（DRP） 发展研究方案的具体目标是： 1)在全国范围内宣传试点转化性脑肿瘤研究项目的启动资金的可用性 广泛的可用媒体来源。 2)通过这一机制确定具有显著改善大脑潜力的创新项目 肿瘤治疗和预后，包括通过更好地了解这种疾病的生物学。 3)促进SPORE调查人员之间以及与其他调查人员的合作， 发展新的和创新的想法。 4)加强SPORE领导人与外部调查人员之间的沟通，以鼓励 在脑肿瘤中开发创新的翻译策略。 5)确保计划的灵活性，以便有希望的发展项目可以：a）为 第二年或第三年; B）鼓励申请校外同行审查资金c）扩大到 成为一个完整的项目。 脑癌孢子已经建立了明确的指导方针和程序，征集，选择， 监测发展研究奖，包括具体的标准选择和资金，通过 同行审查机制，以及密切监测和SPORE之间合作的机制 领导者和计划获奖者，以提高转化研究目标的质量。在上一次融资中， 在此期间，我们开始支持新的想法，并招募新的研究人员来研究脑肿瘤，资助31 其中两个奖项为本次重新提交申请的项目做出了贡献。取得的进步 DRP的研究人员证明了该项目在MDACC脑癌中的成功实施 孢子，包括出版物在自然细胞生物学，细胞，癌细胞和癌症研究，和 获得额外的NIH和其他与DRP项目直接相关的资金。DRP已经成为一个 新概念的孵化器和我们脑癌孢子的基石。

SUMMMARY: DEVELOPMENTAL RESEARCH PROGRAM (DRP) The specific aims of the Developmental Research Program are to: 1) Publicize the availability of start-up funds for pilot translational brain tumor research projects across a broad spectrum of available media sources. 2) Identify through this mechanism innovative projects that have significant potential for improving brain tumor therapy and prognosis, including through better understanding the biology of this disease. 3) Foster collaborative efforts among SPORE investigators and with other investigators to encourage the development of new and innovative ideas. 4) Enhance communications between SPORE leaders and outside investigators to encourage the development of innovative translational strategies in brain tumors. 5) Ensure program flexibility so that developmental projects that show promise can be: a) funded for a second or third year; b) encouraged to apply for extramural peer-reviewed funding c) expanded to become full SPORE projects. The Brain Cancer SPORE has established clear guidelines and processes for solicitation, selection, and monitoring of the Developmental Research Awards, including specific criteria for selection and funding through a peer review mechanism, and mechanisms for close monitoring of, and collaboration between the SPORE leaders and program awardees to enhance the quality of the translational research goals. In the last funding period, we initiated support of new ideas and recruited new investigators to study brain tumors, funding 31 awards, two of which contributed to the Projects of this resubmission application. The advances made by investigators in the DRP testify to the success of this program as implemented in this MDACC Brain Cancer SPORE, including publications in Nature Cell Biology, Cell, Cancer Cell, and Cancer Research, and the acquisition of additional NIH and other funding directly related to DRP projects. The DRP has become an incubator of new concepts and a cornerstone of our Brain cancer SPORE.