Development of a blood pressure monitoring system based on smart-camera video recording

项目总结 高血压在全球造成750万人死亡，没有任何警告迹象或症状，并在两年以上的时间内发生 65岁以上的人占三分之一。高血压是导致冠心病的主要危险因素 包括缺血性和出血性中风、肾功能衰竭和视力障碍。最具影响力的行动 抗高血压以频繁的血压测量为代表，这确保了早期 干预及其成功管理。血压监测主要发生在医疗保健提供者(HCP) 通过袖套式设备(例如血压计)办公，只有训练有素的人员才能准确操作 人事部。此外，临床血压测量有可能导致蒙面高血压和白大衣高血压， 两种众所周知的现象阻碍了正确的BP评估和正确的治疗计划的分配 近40%的患者。其他替代方案包括动态血压监测(ABPM)和家庭 血压测量(HBPM)设备由于成本、实用性和 不准确。Ovid BP提出了一项创新技术，以实现全面的BP检测和管理 通过专利软件，利用当今先进的智能手机摄像头技术来捕捉 确定患者血压所需的生物标志物。该解决方案由一种算法支持，该算法估计BP 来自心脏的QRS信号，该信号是通过分析患者的垂直头而专门捕获的 运动(VHM)。此外，面部血流的速度是通过众所周知的实践观察的 视频体积描记(VPPG)。有了这些数据，系统就能够产生瞬时炉膛 速率周期(TRI)和瞬时脉冲传输时间(PTTI)，通过基于云的算法进行分析 在短时间内产生收缩和舒张压以及心率。奥维德的技术已经 与临床级HBPM设备进行了体内测试，并与参考文献显示出很强的相关性 按现代标准测量的尺寸。在这一阶段的应用中，Ovid BP将评估其可行性 在面对可能影响vPPG和QRS的变量时，建议的方法如何正确检测BP 估计。具体活动将包括对选定的人类受试者进行研究，以验证该技术的有效性 水银血压计，并调查年龄、性别、肤色和血压基线作为病因的作用 错误的数量。收集的数据将用于执行解决任何相关问题所需的算法改进 有了这些变量。拟议的第一阶段研究的结论将确定Ovid BP的可行性 基于视频的血压测量方法。在第二阶段，Ovid将进行一项更大规模的研究，以确定和解决 其他影响读数的关键问题，包括可能阻碍读数的皮肤病 准确评估VHM和PPG。

PROJECT SUMMARY Hypertension causes 7.5 M deaths worldwide with no warning signs or symptoms and occurs in more than two thirds of individuals over the age of 65. Hypertension represents a major risk factor for coronary heart problems including ischemic and hemorrhagic strokes, kidneys failure, and visual impairment. The most impactful action against hypertension is represented by frequent blood pressure (BP) measurements, which assure early intervention and its successful management. BP monitoring occurs mainly at the Health Care Provider’s (HCP) office through cuff-based devices (e.g. sphygmomanometer) that can only accurately be operated by trained personnel. Moreover, clinical BP measurement has the potential to cause Masked and White Coat Hypertension, two well-known phenomena that prevent correct BP assessment and assignment of a proper therapeutic plan in nearly 40% of the patients. Other alternatives are represented by ambulatory BP monitoring (ABPM) and home blood pressure measurement (HBPM) devices which have shown limitations due to costs, practicality, and inaccuracy. Ovid BP proposes an innovative technology to allow comprehensive BP detection and management via patented software that leverages today’s advanced smartphone camera technology to capture the biomarkers required to determine a patients’ BP. The solution is empowered by an algorithm that estimates BP from the heart’s QRS signal, which is specifically captured through analysis of the patients’ Vertical Head Movement (VHM). Additionally, the rate of facial blood flow is observed through the well-understood practice of video plethysmography (vPPG). With this data the system is capable of producing the Instantaneous Hearth Rate Period (THRi) and Instantaneous Pulse Transit Time (PTTi), which are analyzed by a cloud-based algorithm yielding systolic and diastolic blood pressure as well as heart rate in a matter of moments. Ovid’s technology has been tested in-vivo against clinical-grade HBPM devices and has exhibited a strong correlation to the reference measurements obtained by the modern standard. In this Phase I application, Ovid BP will assess the feasibility of the proposed approach to correctly detect BP when confronted with variables that might affect vPPG and QRS estimation. Specific activities will include a study on selected human subjects to validate the technology against a mercury sphygmomanometer and to investigate the role of age, sex, skin tone, and BP baseline as the cause of errors. Data collected will be used to perform algorithm refinements required to solve any issues associated with these variables. The conclusion of the proposed Phase I study will establish the feasibility of Ovid BP’s video-based approach to measuring BP. During Phase II, Ovid will conduct a larger study to identify and solve other key issues affecting the readings, including potential dermatological conditions that may impede the accurate assessment of both VHM and PPG.