Per- and Polyfluoroalkyl substances (PFAS) Exposures and COVID-19 in Firefighters

消防员中的全氟烷基物质和多氟烷基物质 (PFAS) 暴露和 COVID-19

• 批准号: 10256062
• 负责人: Jefferey L. Burgess
• 金额: $ 15.01万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-08 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10256062
• 关键词: 19 year old; 2019-nCoV; Adult; Alkanesulfonates; Antibodies; Antibody Response; Antibody titer measurement; Arizona; Biological; Blood; COVID-19; COVID-19 patient; COVID-19 severity; COVID-19 vaccine; Cessation of life; Child; Communicable Diseases; Coronavirus; Coughing; Diagnostic tests; Diphtheria; Disease; Elderly; Enrollment; Exposure to; Fever; Fire - disasters; General Population; Goals; Health; Hospitalization; Immune response; Immunity; Immunoglobulin G; Immunoglobulin M; Individual; Infection; Isomerism; Life; Linear Regressions; Maternal Exposure; Measurable; Measures; Medical; Modeling; Mumps; Nature; Nose; Outcome; Pilot Projects; Population; Postdoctoral Fellow; Prospective cohort; Publishing; Recovery; Registries; Reporting; Research; Risk; Risk Factors; Rubella; SARS coronavirus; SARS-CoV-2 immune response; SARS-CoV-2 infection; Secondary Immunization; Serology; Serum; Severe Acute Respiratory Syndrome; Severities; Surveys; Symptoms; Testing; Tetanus; Time; Virus; antibody test; asymptomatic COVID-19; fire fighter; ground water; high risk; innovation; male; pandemic disease; perfluorohexane; programs; recruit; respiratory; response; sample collection; symptomatic COVID-19

PROJECT SUMMARY/ABSTRACT The spread of SARS-CoV-2 infection and its associated disease state, COVID-19, has led to a global pandemic. Exposure to per- or polyfluoroalkyl substances (PFAS) is associated with reduced immune response, but its effect on COVID-19 is not known. We have a time-sensitive opportunity to determine the effect of serum PFAS on COVID-19, building on a unique statewide firefighter testing program for SARS-CoV-2 antibodies. Our long- term goal is to identify health risks of PFAS mixtures. Our objective in this application is to evaluate the effects of PFAS exposure levels in firefighters in regards to the severity of and immune response to COVID-19 infection. Our hypotheses are that increased PFAS serum concentrations will increase the severity of COVID-19 infection and reduce post-recovery serologic titers, which could thereby increase risk of later re-infection. We will test these hypotheses through two specific aims: 1) Determine the association of serum PFAS concentrations with infection severity; and 2) Determine the association of serum PFAS with SARS-CoV-2 antibody titers. For aim 1, recruiting from our state registry, we will enroll 100 Tucson and Phoenix firefighters with positive SARS-CoV- 2 IgM and/or IgG antibodies, and collect and analyze their serum for PFAS. Using an online survey instrument completed at the time of biological sample collection, we will obtain information on whether the subjects had COVID-19 infection(s) confirmed by diagnostic testing, extent of symptoms (if any) consistent with COVID-19 infection, and whether they were hospitalized. We will evaluate the association between serum PFAS and: 1) severity of symptoms; 2) symptomatic vs. asymptomatic COVID-19 infection; and 3) hospitalization. For aim 2, we will repeat SARS-CoV-2 IgG testing after five months and ten months in all firefighters enrolled in the study to measure changes in immune response and to test the association of PFAS levels and longitudinal changes in IgG using generalized linear regression models that account for repeated measures. At study completion, we will have documented the effects of PFAS exposure on the likelihood of a symptomatic COVID-19 infection and symptom severity in a highly exposed population, as well as effects of PFAS exposure on the subsequent immune response persistence. The proposed research is significant given the potential for PFAS exposure to increase the risk of already severe health consequences of COVID-19 and to reduce long-term immune response. The proposed research is innovative as it is the first to our knowledge to determine the association between serum PFAS levels and COVID-19.

项目摘要/摘要 SARS-CoV-2感染和与其相关的疾病状态新冠肺炎的传播已导致一场全球大流行。 暴露于全氟烷基或多氟烷基物质(PFAS)与免疫反应降低有关，但其 对新冠肺炎的影响尚不清楚。我们有一个时间敏感的机会来确定血清PFAS的效果 在新冠肺炎上，建立了一个独特的全州消防员检测SARS-CoV-2抗体的计划。我们的长- 长期目标是确定全氟辛烷磺酸混合物的健康风险。我们在这个应用程序中的目标是评估效果 消防员接触全氟辛烷磺酸水平与新冠肺炎感染的严重程度和免疫反应的关系。 我们的假设是，增加PFAS血清浓度将增加新冠肺炎感染的严重程度 并降低康复后的血清学滴度，从而可能增加以后再次感染的风险。我们将测试 这些假设通过两个特定的目的：1)确定血清PFAS浓度与 2)确定血清PFAS与SARS-CoV-2抗体滴度的关系。为了达到目标 1，从我们的州登记中招募，我们将招收100名SARS-CoV阳性的图森和凤凰城消防员- 2免疫球蛋白M和/或免疫球蛋白抗体，并收集和分析他们的血清用于PFAS。使用在线调查工具 在采集生物样本时完成，我们将获得受试者是否有 新冠肺炎感染(S)经诊断测试确认，症状程度(如有)与新冠肺炎一致 感染，以及他们是否住院。我们将评估血清PFAS与：1) 症状的严重性；2)有症状与无症状的新冠肺炎感染；以及3)住院。对于目标2， 我们将在5个月和10个月后对所有参加研究的消防员进行SARS-CoV-2免疫球蛋白检测 测量免疫反应的变化，并测试PFAS水平与纵向变化的关系 在免疫球蛋白中，使用考虑重复测量的广义线性回归模型。在研究完成后，我们 将记录接触全氟辛烷磺酸对出现症状的新冠肺炎感染的可能性的影响 高暴露人群的症状严重程度以及全氟辛烷磺酸暴露对随后 免疫反应持久性。考虑到全氟辛烷磺酸暴露于 增加新冠肺炎本已严重健康后果的风险，并降低长期免疫力 回应。这项拟议的研究是创新的，因为它是我们所知的第一个确定这种联系的研究 血清PFAS水平与新冠肺炎之间的关系。