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Influences of Early and Later Life Events on Cognition and All-Cause Dementia in China

中国早年和晚年生活事件对认知和全因痴呆的影响

基本信息

批准号：
10266068
负责人：
Rose Maria Li
金额：
$ 52.35万
依托单位：
ROSE LI AND ASSOCIATES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10266068
关键词：
Adult Affect Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Americas Childhood China Chinese People Cognition Cognitive Communities Country Data Dementia Diabetes Mellitus Earthquakes Economics Education Elderly Employee Environmental Risk Factor Event Extended Family Family Famines Friends Funding Geography Goals Government Officials Growth Health Health and Retirement Study Impaired cognition Incidence Individual Interview Lead Life Life Cycle Stages Life Expectancy Link Literature Longitudinal Studies Measures Mental Depression Modeling Natural Disasters Obesity Older Population Paper Patients Physical environment Politics Population Population Study Publishing Recording of previous events Research Resources Respondent Retirement Risk Risk Factors Sampling Smoking Social isolation Societies Socioeconomic Status Stressful Event Surveys United States Visual impairment Woman cognitive ability cost dementia risk design drinking farmer follow-up gender difference hearing impairment improved life history lifestyle factors low income country men middle age novel outcome prediction physical inactivity protective factors public health relevance trend

项目摘要

Abstract Rising life expectancy is contributing to rapid increases in the size of the older population and is expected to lead to a sharp rise in Alzheimer’s disease and Alzheimer’s disease related dementias from about 47 million people worldwide today, to potentially more than 140 million in 2050. However, recent population studies have found that the incidence of Alzheimer’s disease and Alzheimer’s disease related dementias is lower than that indicated by previous projections in some countries, but greater in others. Lifestyle factors as well as environmental factors might reduce or increase an individual’s risk of developing dementia. We propose to advance our understanding of protective and risk factors for late-life cognitive decline and Alzheimer’s disease and Alzheimer’s disease-related dementias (hereafter referred to as dementia) in China. We propose a novel life-course model of risk factors, building on the recently proposed model by the Lancet commission, which links dementia risk to early and mid-life factors, within the context of historical, institutional, and physical environments, including obesity, diabetes hearing loss, visual impairment, smoking, drinking, depression, physical inactivity, social isolation, and socioeconomic status. Specifically, this project aims to further study early and mid-life personal, family, community, and external factors that may contribute to late-life cognition and dementia risk using new, retrospective life-history interview data in China.

摘要