Influences of Early and Later Life Events on Cognition and All-Cause Dementia in China

中国早年和晚年生活事件对认知和全因痴呆的影响

基本信息

  • 批准号:
    10266068
  • 负责人:
  • 金额:
    $ 52.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-15 至 2023-04-30
  • 项目状态:
    已结题

项目摘要

Abstract Rising life expectancy is contributing to rapid increases in the size of the older population and is expected to lead to a sharp rise in Alzheimer’s disease and Alzheimer’s disease related dementias from about 47 million people worldwide today, to potentially more than 140 million in 2050. However, recent population studies have found that the incidence of Alzheimer’s disease and Alzheimer’s disease related dementias is lower than that indicated by previous projections in some countries, but greater in others. Lifestyle factors as well as environmental factors might reduce or increase an individual’s risk of developing dementia. We propose to advance our understanding of protective and risk factors for late-life cognitive decline and Alzheimer’s disease and Alzheimer’s disease-related dementias (hereafter referred to as dementia) in China. We propose a novel life-course model of risk factors, building on the recently proposed model by the Lancet commission, which links dementia risk to early and mid-life factors, within the context of historical, institutional, and physical environments, including obesity, diabetes hearing loss, visual impairment, smoking, drinking, depression, physical inactivity, social isolation, and socioeconomic status. Specifically, this project aims to further study early and mid-life personal, family, community, and external factors that may contribute to late-life cognition and dementia risk using new, retrospective life-history interview data in China.
摘要

项目成果

期刊论文数量(0)
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Rose Maria Li其他文献

The exclusion of never-married women from Chinese fertility surveys.
将未婚女性排除在中国生育调查之外。
  • DOI:
    10.2307/2137920
  • 发表时间:
    1996
  • 期刊:
  • 影响因子:
    2.1
  • 作者:
    Rose Maria Li;Susan F. Newcomer
  • 通讯作者:
    Susan F. Newcomer

Rose Maria Li的其他文献

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{{ truncateString('Rose Maria Li', 18)}}的其他基金

AHA Collab: NIA Collaboratories for Artificial Intelligence (AI) and Healthy Aging
AHA 合作:NIA 人工智能 (AI) 和健康老龄化合作实验室
  • 批准号:
    10272338
  • 财政年份:
    2021
  • 资助金额:
    $ 52.35万
  • 项目类别:
a2 Collective Coordinating Center Central IRB Option for AITC Pilot Awards
a2 集体协调中心 中央 IRB 选项 AITC 试点奖项
  • 批准号:
    10825366
  • 财政年份:
    2021
  • 资助金额:
    $ 52.35万
  • 项目类别:
Harmonization of Cross-National Studies of Aging to HRS
跨国老龄化研究与 HRS 的协调
  • 批准号:
    10430546
  • 财政年份:
    2010
  • 资助金额:
    $ 52.35万
  • 项目类别:
The New Immigrant Survey: A Pilot Study
新移民调查:试点研究
  • 批准号:
    9530437
  • 财政年份:
    1995
  • 资助金额:
    $ 52.35万
  • 项目类别:
    Interagency Agreement

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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  • 财政年份:
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
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影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
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