Influences of Early and Later Life Events on Cognition and All-Cause Dementia in China

中国早年和晚年生活事件对认知和全因痴呆的影响

• 批准号: 10266068
• 负责人: Rose Maria Li
• 金额: $ 52.35万
• 依托单位: ROSE LI AND ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10266068
• 关键词: Adult; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Americas; Childhood; China; Chinese People; Cognition; Cognitive; Communities; Country; Data; Dementia; Diabetes Mellitus; Earthquakes; Economics; Education; Elderly; Employee; Environmental Risk Factor; Event; Extended Family; Family; Famines; Friends; Funding; Geography; Goals; Government Officials; Growth; Health; Health and Retirement Study; Impaired cognition; Incidence; Individual; Interview; Lead; Life; Life Cycle Stages; Life Expectancy; Link; Literature; Longitudinal Studies; Measures; Mental Depression; Modeling; Natural Disasters; Obesity; Older Population; Paper; Patients; Physical environment; Politics; Population; Population Study; Publishing; Recording of previous events; Research; Resources; Respondent; Retirement; Risk; Risk Factors; Sampling; Smoking; Social isolation; Societies; Socioeconomic Status; Stressful Event; Surveys; United States; Visual impairment; Woman; cognitive ability; cost; dementia risk; design; drinking; farmer; follow-up; gender difference; hearing impairment; improved; life history; lifestyle factors; low income country; men; middle age; novel; outcome prediction; physical inactivity; protective factors; public health relevance; trend

Abstract Rising life expectancy is contributing to rapid increases in the size of the older population and is expected to lead to a sharp rise in Alzheimer’s disease and Alzheimer’s disease related dementias from about 47 million people worldwide today, to potentially more than 140 million in 2050. However, recent population studies have found that the incidence of Alzheimer’s disease and Alzheimer’s disease related dementias is lower than that indicated by previous projections in some countries, but greater in others. Lifestyle factors as well as environmental factors might reduce or increase an individual’s risk of developing dementia. We propose to advance our understanding of protective and risk factors for late-life cognitive decline and Alzheimer’s disease and Alzheimer’s disease-related dementias (hereafter referred to as dementia) in China. We propose a novel life-course model of risk factors, building on the recently proposed model by the Lancet commission, which links dementia risk to early and mid-life factors, within the context of historical, institutional, and physical environments, including obesity, diabetes hearing loss, visual impairment, smoking, drinking, depression, physical inactivity, social isolation, and socioeconomic status. Specifically, this project aims to further study early and mid-life personal, family, community, and external factors that may contribute to late-life cognition and dementia risk using new, retrospective life-history interview data in China.

抽象的 预期寿命的延长导致老年人口规模迅速增加，预计将导致阿尔茨海默病和阿尔茨海默病相关痴呆症的人数急剧增加，从目前全球约 4700 万人增加到 2050 年可能超过 1.4 亿。然而，最近的人口研究发现，阿尔茨海默病和阿尔茨海默病相关痴呆症的发病率低于之前预测的 在某些国家，但在其他国家则更大。 生活方式因素以及环境因素可能会降低或增加个体患痴呆症的风险。 我们建议加深对中国晚年认知能力下降、阿尔茨海默病和阿尔茨海默病相关痴呆（以下简称痴呆）的保护性和危险因素的了解。 我们基于柳叶刀委员会最近提出的模型，提出了一种新的风险因素生命历程模型，该模型将痴呆风险与早年和中年因素联系起来，在历史、制度和物理环境的背景下，包括肥胖、糖尿病、听力损失、视力障碍、吸烟、饮酒、抑郁、缺乏身体活动、社会孤立和社会经济地位。 具体来说，该项目旨在利用中国新的回顾性生活史访谈数据，进一步研究可能影响晚年认知和痴呆风险的早年和中年个人、家庭、社区和外部因素。