Maternal vitamin C supplementation to decrease effects of smoking during pregnancy on infant lung function and health:Follow-up of 2 randomized trials and association with changes in DNA methylation

母亲补充维生素 C 可减少怀孕期间吸烟对婴儿肺功能和健康的影响:两项随机试验的随访以及与 DNA 甲基化变化的关联

基本信息

  • 批准号:
    10240522
  • 负责人:
  • 金额:
    $ 207.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-21 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant, resulting in more than 450,000 smoke-exposed infants born yearly. Maternal smoking during pregnancy adversely affects lung development as seen by lifelong decreases in pulmonary function and increased risk of asthma. In a randomized controlled trial (RCT), published in JAMA, we have provided evidence that maternal vitamin C supplementation (500 mg daily during pregnancy) can decrease the effects of maternal smoking during pregnancy on offspring lung function and the subsequent incidence of wheeze. The purpose of this ECHO application is to combine the offspring from the prenatal cohorts of two RCTs studying the effects of vitamin C supplementation to pregnant smokers on offspring respiratory outcomes and to determine if the innovative therapy of maternal vitamin C supplementation during pregnancy leads to prolonged improvements on offspring’s pulmonary function tests (PFTs) and respiratory health. To begin to understand mechanisms by which prenatal vitamin C may be preventing changes in the health of offspring of smokers, we examined gene specific DNA methylation from a subset of placentas, cord bloods and buccal swabs (ages 2-5) collected from subjects who were the offspring of prospectively-followed pregnant placebo- treated smokers, vitamin C-treated smokers, or non-smokers. In parallel with the effects of vitamin C on the reduction of the effects of maternal smoking on offspring PFTs and wheeze, the supplementary vitamin C prevented the majority of significant changes in DNA methylation induced by maternal smoking in both placentas and cord blood. Strikingly, this prevention of alterations in DNA methylation was still evident 2-5 years later in offspring buccal swabs. This preliminary data suggests that the mechanism underlying vitamin C’s prevention of some of the effects of maternal smoking on offspring pulmonary health involves the prevention of epigenetic changes induced by maternal smoking. Thus this application has 4 specific aims: 1, to create the combined cohort of offspring from the 2 RCTs of vitamin C supplementation to pregnant smokers; 2, to determine if the protective effects of maternal vitamin C supplementation to pregnant smokers on offspring pulmonary health extend to early adolescence; 3, to begin to characterize the epigenetic mechanisms that appear to underlie the effects of smoking during pregnancy on offspring lung health and on the protective effects of vitamin C; and 4, to gather core data for and interact with the overall ECHO study. Respiratory health will be assessed by longitudinal semi-annual, validated respiratory histories and yearly PFTs beginning at 3 years of age. Buccal swabs will be collected yearly and blood at 6, 9 and 12 years to provide DNA for genetic analysis. DNA methylation changes will be measured by methylation chips and bisulfite sequencing. This study will address how smoking during pregnancy affects respiratory outcomes, provide mechanistic and therapeutic insights, and provide subjects and data to ECHO to address other key outcomes.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Cynthia T McEvoy其他文献

Cynthia T McEvoy的其他文献

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{{ truncateString('Cynthia T McEvoy', 18)}}的其他基金

Vitamin C to Decrease Effects of Smoking during Pregnancy on Offspring Airway Function, Airway Size, and Epigenetic Correlates: VCSIP cohort follow-up through 10 Years of Age
维生素 C 可减少怀孕期间吸烟对后代气道功能、气道大小和表观遗传相关性的影响:VCSIP 队列随访至 10 岁
  • 批准号:
    10658356
  • 财政年份:
    2023
  • 资助金额:
    $ 207.28万
  • 项目类别:
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled Trial
延长稳定早产儿的 CPAP 治疗以促进肺部生长和功能:一项随机对照试验
  • 批准号:
    10026341
  • 财政年份:
    2020
  • 资助金额:
    $ 207.28万
  • 项目类别:
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled Trial
延长稳定早产儿的 CPAP 治疗以促进肺部生长和功能:一项随机对照试验
  • 批准号:
    10480783
  • 财政年份:
    2020
  • 资助金额:
    $ 207.28万
  • 项目类别:
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled Trial
延长稳定早产儿的 CPAP 治疗以促进肺部生长和功能:一项随机对照试验
  • 批准号:
    10268177
  • 财政年份:
    2020
  • 资助金额:
    $ 207.28万
  • 项目类别:
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled Trial
延长稳定早产儿的 CPAP 治疗以促进肺部生长和功能:一项随机对照试验
  • 批准号:
    10683051
  • 财政年份:
    2020
  • 资助金额:
    $ 207.28万
  • 项目类别:
Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled Trial
延长稳定早产儿的 CPAP 治疗以促进肺部生长和功能:一项随机对照试验
  • 批准号:
    9803238
  • 财政年份:
    2019
  • 资助金额:
    $ 207.28万
  • 项目类别:
Maternal vitamin C supplementation to decrease effects of smoking during pregnancy on infant lung function and health:Follow-up of 2 randomized trials and association with changes in DNA methylation
母亲补充维生素 C 可减少怀孕期间吸烟对婴儿肺功能和健康的影响:两项随机试验的随访以及与 DNA 甲基化变化的关联
  • 批准号:
    9355720
  • 财政年份:
    2016
  • 资助金额:
    $ 207.28万
  • 项目类别:
Maternal vitamin C supplementation to decrease effects of smoking during pregnancy on infant lung function and health:Follow-up of 2 randomized trials and association with changes in DNA methylation
母亲补充维生素 C 可减少怀孕期间吸烟对婴儿肺功能和健康的影响:两项随机试验的随访以及与 DNA 甲基化变化的关联
  • 批准号:
    9262768
  • 财政年份:
    2016
  • 资助金额:
    $ 207.28万
  • 项目类别:
Maternal vitamin C supplementation to decrease effects of smoking during pregnancy on infant lung function and health:Follow-up of 2 randomized trials and association with changes in DNA methylation
母亲补充维生素 C 可减少怀孕期间吸烟对婴儿肺功能和健康的影响:两项随机试验的随访以及与 DNA 甲基化变化的关联
  • 批准号:
    10004723
  • 财政年份:
    2016
  • 资助金额:
    $ 207.28万
  • 项目类别:
Continued follow-up of the Vitamin C and Smoking in Pregnancy (VCSIP) cohorts through the ECHO consortium, focus on Echo-wide protocols, respiratory outcomes, airway function, and epigenetic changes
通过 ECHO 联盟继续跟踪维生素 C 和妊娠期吸烟 (VCSIP) 队列,重点关注 Echo 范围内的方案、呼吸结果、气道功能和表观遗传变化
  • 批准号:
    10743723
  • 财政年份:
    2016
  • 资助金额:
    $ 207.28万
  • 项目类别:

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“U-25人”的法律地位研究——15岁的自主权,对25岁五岁的帮助
  • 批准号:
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  • 批准号:
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