Novel actions of beta-adrenoceptor antagonists: implications for the treatment of cardiac failure

市场上几乎有2-3种药物作用于G蛋白偶联受体，许多是阻断受体的拮抗剂。拮抗剂被视为惰性化合物，阻止天然神经递质或激素的进入，但最近的研究表明了不同的作用。我们认为-肾上腺素能拮抗剂的非典型作用可能解释了它们在治疗心力衰竭中的作用。我们试图了解这一过程并开发检测方法，以帮助开发治疗心力衰竭的新药。

Almost 2-3 of drugs on the market act on G protein-coupled receptors, and many are antagonists that block receptors. Antagonists were seen as inert compounds that prevent access of natural neurotransmitters or hormones, but recent studies indicate distinct actions. We believe that atypical effects of beta-adrenergic antagonists may explain their usefulness in treating cardiac failure. We seek to understand the process and develop assays to aid the development of new drugs for cardiac failure.