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Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing.

Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing.
用于高通量肽测序的“Edmanase”酶的设计和定向进化。
批准号：
10259868
负责人：
Lei Shi
金额：
$71.47万
依托单位：
ENCODIA, INC.
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-09-13 至 2022-08-31
来源：
https://reporter.nih.gov/project-details/10259868
关键词：
Amino AcidsApplied ResearchAreaBar CodesBasic ScienceBiological AssayBiological SciencesChemicalsCleaved cellClinical ResearchCouplingDNADNA LibraryDNA sequencingDirected Molecular EvolutionDrug TargetingEngineeringEnzymesGoalsImmobilizationLabelLibrariesMedical ResearchModificationMolecularN-terminalPeptide Sequence DeterminationPeptidesPeriodicityPhaseProcessProtein AnalysisProteinsProteomeReagentSurveysTechnologyVariantbasebiological researchcostcost effectivedesigndigitaldrug developmentgenetic selectionhigh throughput analysisimprovedinstrumentnovelprototypescaffoldscreeningsingle moleculeusabilityuser-friendly

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英文摘要
ABSTRACT More accessible and cost-effective technologies for analysis of the proteome would accelerate biological and medical research. The goal of this proposal is to develop enzymatic reagents to enable creation of a highly-scalable digital protein analysis technology. The approach is broadly applicable and greatly improves upon cost, sensitivity, usability, and throughput of current approaches.
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Exploiting metabolic reprogramming to target IDH1 mutated cholangiocarcinoma
  • 批准号：
    10115672
  • 项目类别：
  • 资助金额：
    $17.82万
  • 财政年份：
    2020
  • 负责人：
    Lei Shi
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
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