Novel analogues of human INSL3 as antagonists and probes of testicular function

这种激素，胰岛素样肽3，最近被证明直接作用于男性和女性生殖细胞，导致它们成熟。它作为一种调节生育的治疗剂具有相当大的前景。基于肽的药物可用于治疗不孕症，阻断其作用的药物有很大的潜力作为男性和女性避孕药。为了实现这些目标，我们的项目旨在了解这种肽如何发挥其独特的生物学效应。

The hormone, insulin-like peptide 3, has recently been shown to act directly on male and female germ cells to cause their maturation. It has considerable promise as a therapeutic agent for the regulation of fertility. Drugs based on the peptide may be used to assist in cases of infertility, and drugs that block its action have great potential as male and female contraceptives. Towards these goals, our project aims to understand how this peptide exerts its unique biological effects.