Novel analogues of human INSL3 as antagonists and probes of testicular function

作为睾丸功能拮抗剂和探针的人 INSL3 新型类似物

• 批准号: nhmrc : 1009243
• 负责人: Dr Ravinder Anand-Ivell
• 金额: $ 39.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-analogues-human-testicular-function/109386
• 关键词: Novel; analogues; human; INSL3; antagonists

The hormone, insulin-like peptide 3, has recently been shown to act directly on male and female germ cells to cause their maturation. It has considerable promise as a therapeutic agent for the regulation of fertility. Drugs based on the peptide may be used to assist in cases of infertility, and drugs that block its action have great potential as male and female contraceptives. Towards these goals, our project aims to understand how this peptide exerts its unique biological effects.

这种激素，胰岛素样肽3，最近被证明直接作用于男性和女性生殖细胞，导致它们成熟。作为调节生育能力的治疗剂，它有相当大的前景。基于这种多肽的药物可以用来帮助不孕症，而阻止其作用的药物作为男性和女性避孕药具有巨大的潜力。为了实现这些目标，我们的项目旨在了解这种多肽是如何发挥其独特的生物学效应的。