Project 2: Investigating the role of PAH exposures associated with superfund site proximity in preterm birth etiology through placental transcriptomics and metagenomics
项目 2:通过胎盘转录组学和宏基因组学研究与超级基金地点邻近相关的 PAH 暴露在早产病因学中的作用
基本信息
- 批准号:10559699
- 负责人:
- 金额:$ 24.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-28 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:Aromatic Polycyclic HydrocarbonsAutomobile DrivingBiological AssayBiological MarkersBody mass indexCellsChemicalsChronic lung diseaseClinicalCollaborationsCountyDNA AdductionDNA AdductsDNA MethylationDataDetectionDoseEnvironmental ExposureEthnic OriginEtiologyExposure toGene ExpressionGeographic Information SystemsGestational AgeIn VitroLabelMapsMass FragmentographyMaternal AgeMaternal and Child HealthMeasurableMeasuresMediatingMetagenomicsMethodsModelingMolecularMonitorMorbidity - disease rateNeurocognitive DeficitOutcomePerinatal mortality demographicsPhasePlacentaPredispositionPregnancyPregnant WomenPremature BirthPreventionProspective cohortRaceReportingResearchRetrospective cohortRiceRiskRoleSamplingSerumSignal Recognition ParticleSiliconesSmokingSoilSolidTerm BirthThird Pregnancy TrimesterTimeTissuesVery Low Birth Weight InfantWomanadductadverse pregnancy outcomecohortcomorbidityearly life exposureepigenomicsexperimental studygenome sciencesgenome-wideimprovedinformation system analysisinsightmonitoring devicemortalityperinatal morbiditypopulation basedrecruitremediationresidencesuperfund sitetranscriptome sequencingtranscriptomicstrophoblast
项目摘要
The burden of perinatal morbidity and mortality related to preterm birth (PTB) is astounding. Studies show that
environmental exposures contribute to an increased susceptibility to PTB. Identification of the causative
etiology of PTB is essential to improving global maternal and child health. Our preliminary data reveal that
exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with PTB. We have reported that proximity
to Superfund sites in Harris County is associated with very low birth weight, and our studies reveal higher
levels of PAHs in placentas from PTBs compared to term births specifically in women residing near Superfund
sites. In this proposal we will delve into the molecular underpinnings behind PTB and the specific
environmental exposures of PAHs through use of our established transcriptomic and epigenomic pipelines. We
will leverage our readily available serum and placental samples from a population based and PTB enriched
cohort. Furthermore, geostatistical modeling will be utilized to identify clusters of PTB throughout Harris
County. Our central hypothesis underlying our research is that PAH exposures are associated with an
increased rate of PTB, that transcriptomics and epigenomics will yield readily translatable mechanistic
information on this association, and geostatistical modeling will reveal increased clusters of PTB in proximity to
Superfund sites in Harris County.
与早产 (PTB) 相关的围产期发病率和死亡率的负担令人震惊。研究表明
环境暴露会增加对 PTB 的易感性。识别病因
PTB 的病因学对于改善全球孕产妇和儿童健康至关重要。我们的初步数据表明
接触多环芳烃 (PAH) 与 PTB 相关。我们已经报告过,接近
哈里斯县的超级基金地点与极低的出生体重有关,我们的研究表明,
与足月分娩相比,PTB 胎盘中的 PAH 水平,特别是居住在 Superfund 附近的妇女
网站。在本提案中,我们将深入研究 PTB 背后的分子基础以及具体的
通过使用我们已建立的转录组和表观基因组管道来检测多环芳烃的环境暴露。我们
将利用我们现成的血清和胎盘样本,这些样本来自基于人群且富含 PTB 的样本
队列。此外,地质统计模型将用于识别整个哈里斯地区的 PTB 集群
县。我们研究的中心假设是,PAH 暴露与
PTB 率增加,转录组学和表观基因组学将产生易于翻译的机制
有关这种关联的信息,并且地质统计模型将揭示附近 PTB 集群的增加
哈里斯县的超级基金地点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kjersti Marie Aagaard其他文献
Kjersti Marie Aagaard的其他文献
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{{ truncateString('Kjersti Marie Aagaard', 18)}}的其他基金
Metformin in Pregnancy: Fetal Consequences & Long-term Offspring Outcomes in a NHP Model
妊娠期二甲双胍:对胎儿的影响
- 批准号:
10491266 - 财政年份:2021
- 资助金额:
$ 24.47万 - 项目类别:
Metformin in Pregnancy: Fetal Consequences & Long-term Offspring Outcomes in a NHP Model
妊娠期二甲双胍:对胎儿的影响
- 批准号:
10364417 - 财政年份:2021
- 资助金额:
$ 24.47万 - 项目类别:
Metformin in Pregnancy: Fetal Consequences & Long-term Offspring Outcomes in a NHP Model
妊娠期二甲双胍:对胎儿的影响
- 批准号:
10683230 - 财政年份:2021
- 资助金额:
$ 24.47万 - 项目类别:
Project 2: Investigating the role of PAH exposures associated with superfund site proximity in preterm birth etiology through placental transcriptomics and metagenomics
项目 2:通过胎盘转录组学和宏基因组学研究与超级基金地点邻近相关的 PAH 暴露在早产病因学中的作用
- 批准号:
10116393 - 财政年份:2020
- 资助金额:
$ 24.47万 - 项目类别:
Interrupting the Vicious Cycle of Obesity and Metabolic Syndrome
中断肥胖和代谢综合症的恶性循环
- 批准号:
9985360 - 财政年份:2019
- 资助金额:
$ 24.47万 - 项目类别:
A Multi'omics Approach towards Deciphering the Influence of the Microbiome on Pre
破译微生物组对预防的影响的多组学方法
- 批准号:
8862198 - 财政年份:2013
- 资助金额:
$ 24.47万 - 项目类别:
A Multi'omics Approach towards Deciphering the Influence of the Microbiome on Pre
破译微生物组对预防的影响的多组学方法
- 批准号:
8659859 - 财政年份:2013
- 资助金额:
$ 24.47万 - 项目类别:
A Multi'omics Approach towards Deciphering the Influence of the Microbiome on Pre
破译微生物组对预防的影响的多组学方法
- 批准号:
9091301 - 财政年份:2013
- 资助金额:
$ 24.47万 - 项目类别:
A Multi'omics Approach towards Deciphering the Influence of the Microbiome on Pre
破译微生物组对预防的影响的多组学方法
- 批准号:
8743311 - 财政年份:2013
- 资助金额:
$ 24.47万 - 项目类别:
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