Novel Approaches to pathogenesis, diagnosis &treatment of autoimmune diseases based on new insights into thymus-dependen

一个人依靠他们的免疫系统来保护免受敌对生物的入侵。该系统通常运行良好。入侵者（“非自我”）被免疫系统的巡逻杀手T细胞检测和攻击。这些通常有益的细胞被称为T细胞，因为它们是在一个名为胸腺的器官中形成和培养的，胸腺在儿童时期启动了我们的免疫系统，但到了青春期，福尔斯就陷入了不活动状态。有时胸腺的教育系统出错，它释放的T细胞错误地攻击“自我”而不是“非自我”。这会导致自身免疫性疾病，如1型糖尿病、多发性硬化症和类风湿性关节炎。Euro-Thymaide项目旨在确定自我攻击的T细胞为什么以及如何错误地从胸腺释放到体内。通常，这种错误的T细胞在胸腺内被检测和破坏，然后才有机会逃脱并引起自身免疫性疾病。最终目标是了解胸腺识别过程，帮助免疫系统检测和破坏巡逻身体的有缺陷的T细胞，从而预防自身免疫性疾病的发生。

An individual relies upon their immune system to protect against invasion by hostile organisms. The system usually works well. Invading agents (the 'non-self') are detected and attacked by the immune system's patrolling killer T cells. These normally beneficial cells are called T cells because they were formed and educated in an organ called the thymus, which kick-starts our immune system in childhood, but falls into inactivity by adolescence. Sometimes the education system in the thymus goes wrong and it releases T cells that mistakenly attack 'self' instead of 'non-self'. This causes autoimmune diseases, such as type1 diabetes, multiple sclerosis and rheumatoid arthritis. The Euro-Thymaide project aims to determine why and how self-attacking T cells are mistakenly released from the thymus into the body. Usually such errant T cells are detected and destroyed within the thymus, before they have the opportunity to escape and cause autoimmune diseases. The ultimate objective is to learn about the thymus recognition process and help the immune system detect and destroy faulty T cells that patrol the body, thereby preventing the onset of autoimmune diseases.