Accuracy and Feasibility of Non-Invasive Anemia Screening Assistant (ASIST) Device in Resource-Limited Settings

项目摘要 无创性贫血诊断工具（ASIST器械）的确认和可行性 该项目将建立我们的新的非侵入性，便携式，低- 成本装置，用于资源贫乏地区慢性营养性和溶血性贫血的诊断。这 该设备有可能减轻中低收入国家贫血的患病率， 结果，特别是在孕妇和少女。 尽管世界卫生组织越来越重视贫血，但贫血仍然是一个令人生畏的公共卫生问题。 这一问题影响到世界三分之一的人口，大部分疾病负担在低水平和低水平， 中等收入国家（LMICs）。孕妇和幼儿是最脆弱的群体 这些人口。妊娠期严重贫血对可预防 怀孕期间和分娩过程中的发病率和死亡率。对于一个 贫血的母亲，有长期的神经发育后果。 在资源丰富的国家，贫血可以使用微创护理点诊断 器械与营养和溶血原因可以区分，而无需进行侵入性检测， 呼出的一氧化碳是血红蛋白的分解产物。在低收入和中等收入国家 在不容易获得这种类型的测试的国家（LMIC），贫血的诊断是 经常不准确或一起错过。根据全球贫血负担，特别是在 LMIC，需要一种低成本的设备，可以非侵入性地检测贫血，并帮助 区分营养和溶血原因，为临床决策提供信息。

Project Summary Validation and Feasibility Non-Invasive Anemia Diagnostic Tool (ASIST Device) This project will establish the accuracy and feasibility of our novel non-invasive, portable, low- cost device to diagnose chronic nutritional and hemolytic anemia in resource poor areas. This device has the potential to mitigate the prevalence of anemia in LMICs, improving health outcomes, especially in pregnant women and adolescent girls. Despite increased attention from the WHO, anemia continues to be a formidable public health issue affecting a third of the world's population, with much of the disease burden in low- and middle- income countries (LMICs). Pregnant women and young children are the most vulnerable of these populations. Severe anemia in pregnancy contributes significantly to preventable morbidity and mortality both during pregnancy and in the delivery process. For the fetus of an anemic mother, there are long-term neurodevelopmental consequences. In resource-rich countries, anemia can be diagnosed using minimally invasive point of care devices and nutritional and hemolytic causes can be differentiated without invasive testing using exhaled Carbon Monoxide, a breakdown product of hemoglobin. In low- and middle-income countries (LMICs), where this type of testing is not readily available, the diagnosis of anemia is often inaccurate or missed all together. Based on the global burden of anemia, especially in LMICs, there is a need for a low-cost device that can non-invasively detect anemia and help to distinguish between nutritional and hemolytic causes to inform clinical decision making.