Accuracy and Feasibility of Non-Invasive Anemia Screening Assistant (ASIST) Device in Resource-Limited Settings

资源有限环境中非侵入性贫血筛查辅助 (ASIST) 设备的准确性和可行性

• 批准号: 10575222
• 负责人: Allison Judkins
• 金额: $ 22.78万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10575222
• 关键词: 12 year old; Adolescent; Adult; Affect; Africa; Age; Anemia; Asia; Attention; Blood; Blood Tests; Carbon Monoxide; Child; Chronic; Classification; Clinical; Color; Community Health; Community Health Aides; Country; Data; Decision Making; Development; Devices; Diagnosis; Diagnostic; Disease; Evaluation; Exhalation; Feasibility Studies; Female Adolescents; Fetus; Government; Health; Health care facility; Hemoglobin; Hemoglobin concentration result; Hemolytic Anemia; Incidence; India; Infant; Iron; Low Birth Weight Infant; Maternal Mortality; Measurement; Measures; Methods; Morbidity - disease rate; Mothers; Non-Invasive Detection; Nutritional; Outcome; Patient Recruitments; Patients; Perception; Physical Examination; Population; Predictive Value; Pregnancy; Pregnant Women; Premature Birth; Prevalence; Process; Provider; Public Health; Reference Standards; Resource-limited setting; Resources; Running; Rural; Skin; Skin Pigmentation; Small for Gestational Age Infant; Specificity; Surveys; System; Testing; Training; Validation; Variant; Visual; Vulnerable Populations; acceptability and feasibility; antenatal care; brain metabolism; burden of illness; clinical decision-making; clinically relevant; combat; cost; diagnostic tool; effective therapy; feasibility testing; health economics; high risk; improved; in vivo; instrument; low and middle-income countries; maternal risk; minimally invasive; mortality; novel; patient population; point of care; portability; pregnant teen; productivity loss; screening; screening program; standard of care; tertiary care; tool

Project Summary Validation and Feasibility Non-Invasive Anemia Diagnostic Tool (ASIST Device) This project will establish the accuracy and feasibility of our novel non-invasive, portable, low- cost device to diagnose chronic nutritional and hemolytic anemia in resource poor areas. This device has the potential to mitigate the prevalence of anemia in LMICs, improving health outcomes, especially in pregnant women and adolescent girls. Despite increased attention from the WHO, anemia continues to be a formidable public health issue affecting a third of the world's population, with much of the disease burden in low- and middle- income countries (LMICs). Pregnant women and young children are the most vulnerable of these populations. Severe anemia in pregnancy contributes significantly to preventable morbidity and mortality both during pregnancy and in the delivery process. For the fetus of an anemic mother, there are long-term neurodevelopmental consequences. In resource-rich countries, anemia can be diagnosed using minimally invasive point of care devices and nutritional and hemolytic causes can be differentiated without invasive testing using exhaled Carbon Monoxide, a breakdown product of hemoglobin. In low- and middle-income countries (LMICs), where this type of testing is not readily available, the diagnosis of anemia is often inaccurate or missed all together. Based on the global burden of anemia, especially in LMICs, there is a need for a low-cost device that can non-invasively detect anemia and help to distinguish between nutritional and hemolytic causes to inform clinical decision making.

项目摘要 验证和可行性非侵入性贫血诊断工具(ASIST设备) 该项目将确定我们的新型非侵入性、便携、低成本 用于诊断资源贫乏地区慢性营养性和溶血性贫血的成本设备。这 该设备有可能缓解LMICs中的贫血患病率，改善健康 结果，特别是孕妇和青春期女孩。 尽管世界卫生组织越来越重视贫血，但它仍然是一个令人敬畏的公共卫生问题 影响世界三分之一人口的问题，大部分疾病负担在低和 中等收入国家(LMIC)。孕妇和幼儿是最易受伤害的群体 这些种群中。妊娠期严重贫血对可预防的影响很大 怀孕期间和分娩过程中的发病率和死亡率。对于一个人的胎儿来说 母亲贫血，会有长期的神经发育后果。 在资源丰富的国家，可以使用微创护理点诊断贫血。 设备以及营养和溶血原因可以在不进行侵入性测试的情况下使用 呼出一氧化碳，这是血红蛋白的分解产物。在中低收入人群中 在没有这种检测方法的国家(LMIC)，贫血的诊断是 经常不准确或全部遗漏。根据全球贫血症负担，特别是在 LMIC，需要一种低成本的设备，能够非侵入性地检测贫血并帮助 区分营养和溶血原因，为临床决策提供信息。