A technological approach for performance status assessment in advanced cancer patients
晚期癌症患者体能状态评估的技术方法
基本信息
- 批准号:10573160
- 负责人:
- 金额:$ 55.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAdvanced Malignant NeoplasmAssessment toolCancer PatientCaringCellular PhoneCessation of lifeClinicalClinical TrialsDataData ReportingDevicesDisease ProgressionEastern Cooperative Oncology GroupEligibility DeterminationEmergency department visitFundingGoalsGuidelinesHealth PersonnelHealthcareHomeHome Care ServicesHospice CareHospitalizationHourKarnofsky Performance StatusLinkMeasurementMeasuresMedical Care TeamMethodsMonitorOncologistOncologyOutcomePalliative CarePatient Self-ReportPatientsPerformancePerformance StatusPhysical activityPhysical assessmentPhysiciansQuality IndicatorQuality of lifeResearchSolid NeoplasmStandardizationStratificationSymptomsSystemSystemic TherapyTechnologyTimeToxic effectValidity and ReliabilityWorkclinical decision-makingclinical trial protocolcyber infrastructuredigitalevidence basefitnessimprovedinnovationpredict clinical outcomeprognosticprognosticationrecruitrisk stratificationsensorstandard of caresurvival outcomesurvival predictiontoolwrist worn device
项目摘要
PROJECT SUMMARY
Although widely used and accepted in oncology practice to determine patient eligibility and physical tolerance
for clinical trial participation, performance status—the single most powerful prognostic and key clinical
decision-making tool across all solid tumor types—has one very significant limitation: its subjectivity. Because
of the association with survival, performance status scores are routinely assigned by the clinician as a
prediction of survival (prognostication). These subjectively determined scores are also used to evaluate fitness
capability for treatment, as a stratification and selection factor for clinical trial eligibility, to assess ability to
continue treatment on a clinical trial protocol, as a global indicator of quality of life, and to evaluate eligibility
and allocation of healthcare funds for hospice and home care services. We propose to examine the association
between continuously and objectively measured physical activity (PA) and clinician-assessed performance
status scores, overall patient survival, and clinical outcomes of significance (i.e., symptom burden, quality of
life measures, death, disease progression, treatment termination due to toxicity, hospitalizations and
emergency room visits, and referral for supportive/hospice care). This project will harness the technological
capacity of a system (CYCORE) that links home-based monitoring sensors to a cyber-infrastructure and can
send data in real time to the patient's healthcare team. To determine if objectively assessed PA levels are
associated with health care provider-assessed performance status scores and overall survival, we will recruit
75 patients for each of four performance status groups (levels 0-3). They will provide PA-related data for 7
days by wearing two PA devices—one commercially available and the second research-grade. We will
correlate those data with physician-assessed performance status scores and survival outcomes. To evaluate
the feasibility of long-term and continuous PA monitoring and the associations with clinical outcomes in
advanced cancer patients, we will recruit 100 patients who, for 6 months, will wear a commercially available PA
device and will provide PA- and self-reported data from their personal smartphone. We will correlate those data
to multiple clinical outcomes. Our long-term goal is to eliminate the subjectivity in performance status
assessments.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael J Overman其他文献
Michael J Overman的其他文献
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{{ truncateString('Michael J Overman', 18)}}的其他基金
A technological approach for performance status assessment in advanced cancer patients
晚期癌症患者体能状态评估的技术方法
- 批准号:
10356020 - 财政年份:2020
- 资助金额:
$ 55.91万 - 项目类别:
A technological approach for performance status assessment in advanced cancer patients
晚期癌症患者体能状态评估的技术方法
- 批准号:
10092983 - 财政年份:2020
- 资助金额:
$ 55.91万 - 项目类别:
Project 1: Personalized Adjuvant Immunotherapy for High-risk Colorectal Cancer.
项目1:高危结直肠癌的个体化辅助免疫治疗。
- 批准号:
10415968 - 财政年份:2019
- 资助金额:
$ 55.91万 - 项目类别:
Project 1: Personalized Adjuvant Immunotherapy for High-risk Colorectal Cancer.
项目1:高危结直肠癌的个体化辅助免疫治疗。
- 批准号:
10226087 - 财政年份:2019
- 资助金额:
$ 55.91万 - 项目类别:














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