Supplement for Equipment Purchase - Hyperspectral Near Infrared Confocal Microscope

设备采购补充-高光谱近红外共焦显微镜

• 批准号: 10582344
• 负责人: Nicole Marie Iverson
• 金额: $ 25万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582344
• 关键词: Biological Process; Communities; Funding; Goals; Image; In Vitro; Laboratories; Measures; Microscope; Movement; Nitric Oxide; Research; Research Personnel; Signal Transduction; Signaling Molecule; Specificity; System; Time; United States National Institutes of Health; biological systems; equipment acquisition; improved; in vivo; parent grant; sensor; single walled carbon nanotube; small molecule

PROJECT SUMMARY/ABSTRACT Nitric oxide (NO) is a key signaling molecule in biological systems, but it is poorly understood due to a lack of temporal and spatial sensors that measure NO. A direct, fast and accurate sensor for measuring NO would be of immense value to ongoing and future research. Single walled carbon nanotubes (SWNT) have excellent potential for use as NO sensors both in vitro and in vivo, but they are not widely used by the research community because they are not readily available in an easy-to-use platform. The Iverson Lab aims to 1) develop new SWNT sensor platforms and modify the current systems to improve sensor specificity and handling, and 2) determine nitric oxide concentration and dynamics with a highly sensitive and accurate sensor. Through the acquisition of a near infrared, hyperspectral confocal microscope, we will be able to more quickly and more accurately accomplish the goals of the R35 parent grant and increase the impact of the funds already supplied by the NIH.

项目总结/摘要 一氧化氮（NO）是生物系统中的一种关键信号分子，但对其了解甚少 由于缺乏直接、快速和准确测量NO. A的时间和空间传感器， NO传感器的研究对目前和未来的研究具有巨大的价值。单个 多壁碳纳米管（SWNT）作为NO传感器具有良好的潜力， 但它们没有被研究界广泛使用，因为它们不是 在一个易于使用的平台上。艾弗森实验室的目标是1）开发新的SWNT 传感器平台并修改当前系统以改进传感器特异性和处理， 和2）以高灵敏度和准确性测定一氧化氮浓度和动力学 传感器.通过近红外，高光谱共聚焦显微镜的收购，我们将 能够更快，更准确地实现R35父母补助金的目标， 增加NIH已经提供的资金的影响。