California National Primate Research Center

项目总结 位于加州大学戴维斯分校的加州国家灵长类研究中心(CNPRC) 下一个五年期(2018年5月1日至 2023年4月30日)。中国石油天然气集团公司的战略重点是多学科研究团队，专注于 人类健康和疾病的非人类灵长类动物模型的开发和使用。目前处于第58个年头 在运作中，CNPRC为全国范围内由NIH支持的一系列调查人员提供服务。从一开始到现在 今年，中国石油天然气集团公司对研究界做出了高度响应，提供了高质量的 由指导核心科学家的智力基础设施驱动的动物、设施、工具和服务 并对非人类灵长类动物进行基础和翻译研究。反映了中国石油天然气集团公司的目标 在以下具体目标方面：(1)开展最先进的研究，科学地为 用跨年龄段的非人灵长类动物模型理解和治疗人类疾病，(2) 为当地、地区和地区的研究人员提供卓越的非人灵长类专业知识和服务 国家层面推进NIH支持的卓越研究，(3)指导和培训下一代 具有非人灵长类专业知识的翻译调查人员，以及(4)确保最高标准的 负责任地进行研究和动物护理。下一个资助期的计划建立在专业知识的基础上， 生产力和创新；与主办机构和国家方案的密切联系；以及最大化 美国国立卫生研究院资助的研究的资源。 加州国家灵长类动物研究中心(CNPRC)正在提交一份改建和翻新报告 关于艾滋病研究中高度优先主题的行政补编的建议。此应用程序 将用于翻新传染病/SIV手术套房和手术准备室的设施。 CNPRC在传染病方面有一个强大的项目，由Koen VanRompay博士领导。重点放在 是SIV模型，在治疗学、疫苗开发和艾滋病毒的共病方面进行积极研究- 被感染的病人。 拟议项目用于购买和安装暖通空调设备。成本的增加导致了这一点 原合同不支持的设备。还包括用于购买以下设备的资金 手术室。 申请的这笔资金将完成这项翻新工作，通过提供 1.美国国立卫生研究院资助的研究人员进行艾滋病毒/艾滋病研究的无菌生存手术套件 2.毗邻的手术准备和程序室，用于小手术、内窥镜检查和 SIV感染动物的脑脊液采样 3.新的支持空间，用于在受SIV感染的动物中进行肺功能测试，作为 艾滋病毒/艾滋病共病的跨学科研究

PROJECT SUMMARY The California National Primate Research Center (CNPRC), located at the University of California, Davis, is supported by the base operating grant #P51-OD011107 for the next five year period (May 1, 2018 through April 30, 2023). The CNPRC has a strategic emphasis on multidisciplinary research teams that focus on the development and use of nonhuman primate models of human health and disease. Currently in the 58th year of operation, the CNPRC serves a range of NIH-supported investigators nationwide. From inception through the current year, the CNPRC has been highly responsive to the research community by providing high quality animals, facilities, tools, and services driven by the intellectual infrastructure of the Core Scientists that guide and conduct basic and translational research with nonhuman primates. The goals for the CNPRC are reflected in the following Specific Aims: (1) Conduct state-of-the-art research and scientifically contribute to the understanding and treatment of human disease with nonhuman primate models across the age spectrum, (2) Provide exceptional nonhuman primate expertise and services to investigators at the local, regional, and national levels to advance NIH-supported research excellence, (3) Mentor and train the next generation of translational investigators with nonhuman primate expertise, and (4) Ensure the highest standards of responsible conduct of research and animal care. Plans for the next funding period build upon expertise, productivity, and innovation; strong ties with the host institution and national programs; and maximizing resources for NIH-funded research. The California National Primate Research Center (CNPRC) is submitting an Alterations and Renovations proposal for the Administrative Supplements related to high priority topics in AIDS research. This application will be for facility renovation for an Infectious Disease/SIV Surgery Suite and Surgery Preparation Room. The CNPRC has a strong program in Infectious Disease led by Dr. Koen VanRompay. The major emphasis of is the SIV model with active research in therapeutics, vaccine development, and co-morbidities of HIV- infected patients. The proposed project is for the purchase and installation of HVAC equipment. Cost increases resulted in this equipment not being supported by the original award. Funds are also included for purchase of equipment for the surgical suite. This funds requested will complete this renovation will enhance HIV/AIDs research at the CNPRC by providing 1. A sterile survival surgery suite dedicated to NIH funded investigators conducting HIV/AIDs research 2. An adjacent surgery preparation and procedure room for minor surgical procedures, endoscopy, and CSF sampling in SIV infected animals 3. New support space to conduct pulmonary function testing in SIV infected animals as part of interdisciplinary studies in HIV/AIDs co-morbities