Aging, PTSD, and the Anterior Cingulate Cortex (ACC)

衰老、创伤后应激障碍 (PTSD) 和前扣带皮层 (ACC)

基本信息

  • 批准号:
    10587057
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

America is aging; baby boomers are now seniors. Staying mentally astute is essential not only for economic survival but also for quality of life. Yet, the pathophysiology of cognitive aging remains ill-defined, a gap preventing development of novel diagnostic, therapeutic, or preventive strategies. This laboratory has identified the anterior cingulate cortex (ACC), the major component of the anterior attention system, as the principal region showing metabolic decline from young to late adulthood. This decline correlates with declining executive functions such as fluency. The ACC mediates statistically the relationship between increasing age and decreasing verbal fluency. Amyloid-free, cognitively intact elders show robust executive but lesser mnemonic deficits. This project will test the hypothesis that ACC dysfunction in the elderly free of preclinical Alzheimer’s disease (AD) is associated with redox dysfunction related to aging and severe stress, the latter as seen in PTSD. Oxidative stress will be measured with 7 T MRI/MRS using the NAD+/NADH ratio, a method developed here recently. Two factors will include: AGE (younger vs. older) and STRESS (healthy vs. chronic active PTSD). Neuropsychological testing and plasma phospho-tau181 [or 217] will confirm absence of preclinical AD as well as revisit the unusual observation: absence of aging-related memory impairment (Logical Memory I & II) —typically viewed as the sine qua non for aging. The anticipated outcomes are 1) the ACC undergoes redox stress related to aging and possibly emotional stress; 2) increasing ACC redox stress will correlate with declining ACC metabolism in the absence of preclinical AD; both will correlate more with declining executive and less with memory dysfunction; 3) ACC metabolism or redox status may serve as a biomarker for cognitive aging in the absence of neurodegeneration; and 4) scientific premise and infrastructure will poise the field to test the potential of antioxidant therapies in preventing or delaying cognitive aging. If successful, aging American would remain mentally sharp for more years. Since the ACC also participates in cognitive reserve, secondary prevention would delay symptoms even if neurodegeneration occurs.
美国正在老龄化;婴儿潮一代现在是老年人。保持头脑敏锐不仅对经济至关重要

项目成果

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JOSE V PARDO其他文献

JOSE V PARDO的其他文献

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{{ truncateString('JOSE V PARDO', 18)}}的其他基金

The Anterior Cingulate Cortex and Cognitive Aging
前扣带皮层和认知衰老
  • 批准号:
    8246798
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
The Anterior Cingulate Cortex and Cognitive Aging
前扣带皮层和认知衰老
  • 批准号:
    8698378
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
The Anterior Cingulate Cortex and Cognitive Aging
前扣带皮层和认知衰老
  • 批准号:
    8793733
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
The Anterior Cingulate Cortex and Cognitive Aging
前扣带皮层和认知衰老
  • 批准号:
    8443347
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
ANTERIOR CINGULATE AND COGNITIVE AGING
前扣带回和认知老化
  • 批准号:
    8171200
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
BRAIN METABOLISM IN PATIENTS UNDERGOING WEIGHT-REDUCTION SURGERY
接受减肥手术患者的大脑代谢
  • 批准号:
    7951680
  • 财政年份:
    2008
  • 资助金额:
    --
  • 项目类别:
BRAIN METABOLISM IN PATIENTS UNDERGOING WEIGHT-REDUCTION SURGERY
接受减肥手术患者的大脑代谢
  • 批准号:
    7606045
  • 财政年份:
    2006
  • 资助金额:
    --
  • 项目类别:
BRAIN METABOLISM IN PATIENTS UNDERGOING WEIGHT-REDUCTION SURGERY
接受减肥手术患者的大脑代谢
  • 批准号:
    7375984
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
Clinical Assessment in Neuropsychiatric Image Databases
神经精神图像数据库的临床评估
  • 批准号:
    6480196
  • 财政年份:
    2002
  • 资助金额:
    --
  • 项目类别:
Clinical Assessment in Neuropsychiatric Image Databases
神经精神图像数据库的临床评估
  • 批准号:
    6658143
  • 财政年份:
    2002
  • 资助金额:
    --
  • 项目类别:

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