Aging, PTSD, and the Anterior Cingulate Cortex (ACC)
衰老、创伤后应激障碍 (PTSD) 和前扣带皮层 (ACC)
基本信息
- 批准号:10587057
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAccountingAdenineAdultAerobic ExerciseAgeAge-associated memory impairmentAgingAlzheimer&aposs DiseaseAmericanAmyloidAnteriorAntioxidantsApoptosisAreaAtrophicAttentionBehavior DisordersBiochemical PathwayBiological MarkersBiologyBrainBrain DiseasesBuffersCell AgingCell RespirationChronicChronic Post Traumatic Stress DisorderClinicalClinical TrialsCognitionCognition DisordersCognitiveCognitive agingCognitive deficitsCysteineDNA DamageDNA MethylationDNA RepairDataDepositionDevelopmentDietDinucleoside PhosphatesDisciplineDiseaseDrug Metabolic DetoxicationEconomicsElderlyEmotional StressEnvironmentExposure toFunctional disorderFutureGenerationsGluconeogenesisGlutathioneHealthHealth behaviorHumanImpaired cognitionImpairmentInflammationInfrastructureInterventionLaboratoriesLipidsMagnetic ResonanceMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasuresMedialMediatingMedicalMemoryMemory impairmentMental disordersMetabolicMetabolic dysfunctionMetabolismMethodsModelingNADHNADPNerve DegenerationNeurodegenerative DisordersNeuropsychological TestsNicotineOccipital lobeOutcomeOxidantsOxidation-ReductionOxidative PhosphorylationOxidative StressPathologicPathway interactionsPatientsPellagraPerformancePersonsPharmacologic SubstancePlasmaPlayPost-Traumatic Stress DisordersPreventionPrevention strategyProteinsPsyche structureQuality of lifeReactive Oxygen SpeciesRegulationResearchResearch PriorityRisk FactorsRoleSecondary PreventionSeveritiesSignal TransductionSirtuinsSiteStressSymptomsSystemTelomere ShorteningTemporal LobeTestingTherapeuticTraumaUniversitiesVeteransVisitWorkaerobic glycolysisaging brainantioxidant therapybaby boomercingulate cortexcofactorcognitive changecognitive reservecombatendophenotypeepigenetic markerexecutive functionglucose metabolismhuman old age (65+)in vivoindexinginterestketogenesislipid biosynthesismitochondrial dysfunctionneuronal excitabilitynicotinamide-beta-ribosidenicotine usenovelnovel diagnosticsoxidationpre-clinicalpreventrehabilitation strategyresponsestress disorderstress managementtau Proteinstherapeutic targetverbalyoung adult
项目摘要
America is aging; baby boomers are now seniors. Staying mentally astute is essential not only for economic
survival but also for quality of life. Yet, the pathophysiology of cognitive aging remains ill-defined, a gap
preventing development of novel diagnostic, therapeutic, or preventive strategies. This laboratory has identified
the anterior cingulate cortex (ACC), the major component of the anterior attention system, as the principal
region showing metabolic decline from young to late adulthood. This decline correlates with declining executive
functions such as fluency. The ACC mediates statistically the relationship between increasing age and
decreasing verbal fluency. Amyloid-free, cognitively intact elders show robust executive but lesser mnemonic
deficits. This project will test the hypothesis that ACC dysfunction in the elderly free of preclinical Alzheimer’s
disease (AD) is associated with redox dysfunction related to aging and severe stress, the latter as seen in
PTSD. Oxidative stress will be measured with 7 T MRI/MRS using the NAD+/NADH ratio, a method developed
here recently. Two factors will include: AGE (younger vs. older) and STRESS (healthy vs. chronic active
PTSD). Neuropsychological testing and plasma phospho-tau181 [or 217] will confirm absence of preclinical AD
as well as revisit the unusual observation: absence of aging-related memory impairment (Logical Memory I &
II) —typically viewed as the sine qua non for aging. The anticipated outcomes are 1) the ACC undergoes redox
stress related to aging and possibly emotional stress; 2) increasing ACC redox stress will correlate with
declining ACC metabolism in the absence of preclinical AD; both will correlate more with declining executive
and less with memory dysfunction; 3) ACC metabolism or redox status may serve as a biomarker for cognitive
aging in the absence of neurodegeneration; and 4) scientific premise and infrastructure will poise the field to
test the potential of antioxidant therapies in preventing or delaying cognitive aging. If successful, aging
American would remain mentally sharp for more years. Since the ACC also participates in cognitive reserve,
secondary prevention would delay symptoms even if neurodegeneration occurs.
美国正在老龄化;婴儿潮一代现在是老年人。保持头脑敏锐不仅对经济至关重要
项目成果
期刊论文数量(0)
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{{ truncateString('JOSE V PARDO', 18)}}的其他基金
BRAIN METABOLISM IN PATIENTS UNDERGOING WEIGHT-REDUCTION SURGERY
接受减肥手术患者的大脑代谢
- 批准号:
7951680 - 财政年份:2008
- 资助金额:
-- - 项目类别:
BRAIN METABOLISM IN PATIENTS UNDERGOING WEIGHT-REDUCTION SURGERY
接受减肥手术患者的大脑代谢
- 批准号:
7606045 - 财政年份:2006
- 资助金额:
-- - 项目类别:
BRAIN METABOLISM IN PATIENTS UNDERGOING WEIGHT-REDUCTION SURGERY
接受减肥手术患者的大脑代谢
- 批准号:
7375984 - 财政年份:2005
- 资助金额:
-- - 项目类别:
Clinical Assessment in Neuropsychiatric Image Databases
神经精神图像数据库的临床评估
- 批准号:
6480196 - 财政年份:2002
- 资助金额:
-- - 项目类别:
Clinical Assessment in Neuropsychiatric Image Databases
神经精神图像数据库的临床评估
- 批准号:
6658143 - 财政年份:2002
- 资助金额:
-- - 项目类别:
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