P&F program

磷

• 批准号: 10586207
• 负责人: Deborah J Wexler
• 金额: $ 31.14万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586207
• 关键词: Area; Award; Basic Science; Bioinformatics; Boston; Catalysis; Categories; Cells; Cellular Metabolic Process; Climate; Clinical; Clinical Research; Collaborations; Consultations; Creativeness; Data; Development; Diabetes Mellitus; Endocrinology; Environment; Evolution; Exposure to; Fostering; Foundations; Funding; Funding Opportunities; Goals; Grant; Industry; Investigation; Investments; Journals; K-Series Research Career Programs; Knowledge; Learning; Measures; Medicine; Metabolism; Mission; Nature; New England; Newsletter; Obesity; Paper; Peer Review; Pilot Projects; Principal Investigator; Process; Productivity; Publications; Publishing; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Science; Scientist; Secure; Talents; Therapeutic; Training; Translational Research; United States National Institutes of Health; base; career; career development; diversity and inclusion; follow-up; high risk; innovation; insight; next generation; nutrition; programs; recruit; sabbatical; skills; success; symposium

PILOT and FEASIBILITY GRANT PROGRAM SUMMARY The Boston Area Diabetes and Endocrinology Research Center Pilot and Feasibility (BADERC P&F) program has been effective both in recruiting and maintaining new talent in diabetes and endocrinology research, and in fostering the most innovative pilot projects among established investigators with a new idea in diabetes research. The subsequent funding history of P&F recipients from our first three funding cycles 2000-2014 has been outstanding, despite the adverse funding climate, with nearly 75% of investigators achieving subsequent PI status on diabetes-related NIH or foundation grants, and the overwhelming majority remaining in academic diabetes-related research. The 73 pilot awards administered over the most recent 10 years of full, active funding, alone (2009-2019) have spawned 87 NIH R-level project grants (or equivalent), estimated at more than $93,000,000 in research funding. As such, the investment of ~$3.9M of P&F funds administered 2009-2019 has realized a >2200% return on investment, exclusive of additional NIH career development awards, and additional foundation and industry funding. Of these 73 awardees, an impressive 77% have obtained subsequent diabetes- related research funding, and 91% remain in academic diabetes research. A further deliberate evolution of the program has been towards funding an increasing number of cutting-edge clinical and translational research projects, comprising over 1/3 of all funded applications in the 2014-2019 funding cycle. During our 2-year funding gap, a testament to our commitment to this impactful program and to growing the next generation of leaders in diabetes research, we have continued to support 7 of the most innovative P&F proposals with a second year of funding, and funded 2 new BADERC-Nutrition Obesity Research Center of Harvard (NORC-H) jointly funded proposals by judicious funding reallocation. Overall, the success of the BADERC P&F program reflects the ability of the investigators who constitute the BADERC research base to recruit and train outstanding, ambitious, creative and productive young investigators. The BADERC P&F program contributes demonstrably to the career progress of these exciting young scientists and their entry into diabetes research. The program has the ultimate goal of fostering the careers of those who will contribute to the advancement of knowledge and therapeutics for all forms of diabetes. In the coming grant period, we will continue to fund and support the most promising P&F projects, and introduce innovations that further the BADERC mission to recruit and retain the most talented and diverse pool of investigators throughout the Boston area in basic, clinical, and translational diabetes-related research.

试点和可行性拨款计划 概括 波士顿地区糖尿病和内分泌研究中心试点和可行性 (BADERC P&F) 计划 在招募和维持糖尿病和内分泌学研究方面的新人才以及在 在糖尿病研究领域具有新理念的知名研究人员中培育最具创新性的试点项目。 从 2000 年至 2014 年的前三个资助周期中，P&F 受助者的后续资助历史是 尽管资助环境不利，但仍表现出色，近 75% 的研究人员实现了后续 PI 与糖尿病相关的 NIH 或基金会拨款状况，绝大多数仍留在学术界 糖尿病相关研究。最近 10 年管理的 73 个试点奖项获得全额、积极资助， 仅 2009-2019 年就产生了 87 项 NIH R 级项目拨款（或同等金额），估计超过 93,000,000 美元的研究经费。因此，2009-2019 年管理的 P&F 基金投资额约为 390 万美元 实现了 >2200% 的投资回报率，不包括额外的 NIH 职业发展奖和额外的 基金会和行业资助。在这 73 名获奖者中，令人印象深刻的是 77% 的人后来患上了糖尿病—— 相关研究经费，91%仍从事糖尿病学术研究。进一步经过深思熟虑的演变 该计划一直致力于资助越来越多的尖端临床和转化研究 项目，占 2014-2019 年资助周期所有资助申请的 1/3 以上。在我们的 2 年资助期间 差距，证明了我们对这一有影响力的计划以及培养下一代领导者的承诺 糖尿病研究中，我们继续支持 7 项最具创新性的 P&F 提案，第二年 资助，并资助2个新的BADERC-哈佛大学营养肥胖研究中心（NORC-H）联合资助 通过明智的资金重新分配提出建议。总体而言，BADERC P&F 计划的成功体现了以下能力： 组成BADERC研究基地的研究人员招募和培养优秀的、雄心勃勃的、 富有创造力和生产力的年轻研究人员。 BADERC P&F 计划对职业生涯做出了明显贡献 这些令人兴奋的年轻科学家的进展及其进入糖尿病研究的情况。该方案具有终极 培养那些将为知识和治疗的进步做出贡献的人的职业目标 所有形式的糖尿病。在接下来的资助期内，我们将继续资助和支持最有前途的 P&F 项目，并引入创新，以进一步推进 BADERC 的使命，即招募和留住最有才华和最优秀的人才 波士顿地区基础、临床和转化糖尿病相关领域的不同研究人员 研究。