Innovative Treatment of Chemotherapy-Induced Painful Peripheral Neuropathy in Adolescents and Young Adults with Cancer: A two arm pilot study
青少年和年轻人癌症患者化疗引起的疼痛性周围神经病变的创新治疗:一项两臂试点研究
基本信息
- 批准号:10560600
- 负责人:
- 金额:$ 18.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-02 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:Acupuncture TherapyAddressAdolescentAdolescent and Young AdultAdolescent and young adult cancer patientsAdultAdverse effectsAffectAgeAnalgesicsAntidepressive AgentsAntiepileptic AgentsBlindedBrief Pain InventoryCessation of lifeChemotherapy-induced peripheral neuropathyChildChild CareClinicClinicalClinical ManagementClinical TrialsClinical assessmentsCommon Terminology Criteria for Adverse EventsConstipationControl GroupsControlled Clinical TrialsCutaneousDataData CollectionDevicesDrug usageEffectivenessElderlyElectric StimulationEuropean Organization for Research and Treatment of CancerEvaluationExperimental DesignsFunctional disorderGoalsItalyKnowledgeMalignant Childhood NeoplasmMalignant NeoplasmsMeasuresMedication ManagementMotorNerveNervous System TraumaNeurologicNeurologistNeuropathyNumbnessOpioidOutcome MeasurePainPain managementPatient Outcomes AssessmentsPatientsPeripheral Nervous SystemPeripheral Nervous System DiseasesPharmaceutical PreparationsPhysical FunctionPhysical PerformancePhysical assessmentPilot ProjectsPlatinum CompoundsProceduresPublishingQuality of lifeQuestionnairesRandomizedReportingResearchSafetySedation procedureSensorySurvival RateSymptomsTechniquesTestingTranscutaneous Electric Nerve StimulationUnited StatesUnited States Food and Drug AdministrationVentilatory DepressionVinca AlkaloidsVincristineWaiting ListsWalkingYogaaddictionarmcancer carecancer paincancer typechemotherapyeffective therapyefficacy evaluationexperienceimprovedinnovationnegative affectnovelpain reductionpain scalepainful neuropathyprimary outcomeprospectivepublic health relevancesecondary outcomeside effecttreatment duration
项目摘要
PROJECT SUMMARY/ABSTRACT
An estimated one in five children in the United States has cancer. Fortunately, the 5-year overall survival rate
has improved over the years and is currently more than 80% for many types of cancer, thanks to advances in
chemotherapy. Unfortunately, chemotherapy drugs have adverse effects such as peripheral neuropathy (so-
called chemotherapy-induced peripheral neuropathy, CIPN). CIPN is a debilitating condition that negatively
affects the quality of life of affected patients. The drugs used to treat CIPN, such as opioids, antiepileptics,
and antidepressants, are often ineffective, and/or have profound adverse effects, such as constipation,
sedation, addiction, respiratory depression, and even death. Furthermore, nonpharmacologic treatments
such as transcutaneous electrical nerve stimulation (TENS), acupuncture, and yoga have shown mixed results.
Importantly, most of the procedures have been tested in adults with CIPN; much less research has been done
in adolescent and young adult (AYA) cancer patients. Consequently, the management of CIPN in AYA patients
with cancer remains a challenge. Thus, this exploratory R21 proposal addresses the unmet need in treating
AYAs with CIPN by introducing a potentially effective noninvasive electrocutaneous nerve stimulation
technique called scrambler therapy (ST), which is different from TENS. Given that the clinical presentation of
CIPN in AYAs is similar to that of older adults, and with supporting evidence from a recently published small
study from Italy, we believe that ST is a promising novel treatment option for patients of all ages with CIPN.
Thus, it is worth investigating this novel treatment further. Our central hypothesis is that ST significantly
reduces pain and improves neuropathy, physical function, and quality of life (QoL) of AYA cancer
patients with CIPN. To test this hypothesis, we propose a prospective, randomized, wait-list controlled pilot
study with two specific aims: Specific Aim 1: To evaluate the efficacy and safety of ST for CIPN in AYA
cancer patients, and Specific Aim 2: To evaluate the impact of ST on physical functioning and quality
of life (QoL) in AYA cancer patients. The overall objective of this proposal is to show that ST may be a
valuable alternative to pharmacologic management of CIPN that can effectively improve pain and
neuropathy and improve QoL for AYA cancer patients with CIPN. We expect to see significant improvement in
pain and other symptom burden of CIPN in AYA patients. Finally, this pilot study is not a mechanistic study.
Instead, it will focus on patient-reported outcomes, physical functioning, and QoL to demonstrate effectiveness.
As such, pain will be our primary outcome measure, whereas physical performance and QoL will be our
secondary outcome measures. The long-term goal is to use ST safely and effectively for all types of
intractable neuropathic pain, which if successful, will result in changes in the clinic.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Salahadin Abdi其他文献
Salahadin Abdi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Salahadin Abdi', 18)}}的其他基金
Cannabidiol/Palmitoylethanolamide sublingual tablets for the treatment of Painful Diabetic Peripheral Neuropathy
大麻二酚/棕榈酰乙醇酰胺舌下片用于治疗疼痛性糖尿病周围神经病变
- 批准号:
10761403 - 财政年份:2023
- 资助金额:
$ 18.56万 - 项目类别:
Innovative Treatment of Chemotherapy-Induced Painful Peripheral Neuropathy in Adolescents and Young Adults with Cancer: A two arm pilot study
青少年和年轻人癌症患者化疗引起的疼痛性周围神经病变的创新治疗:一项两臂试点研究
- 批准号:
10363448 - 财政年份:2022
- 资助金额:
$ 18.56万 - 项目类别:
相似海外基金
Enhancing Structural Competency in School-Based Health Centers to Address LGBTQ+ Adolescent Health Equity
增强校本健康中心的结构能力,以解决 LGBTQ 青少年健康公平问题
- 批准号:
10608426 - 财政年份:2023
- 资助金额:
$ 18.56万 - 项目类别:
Application and feasability of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care - a pilot study
简短的数字筛查工具的应用和可行性,以解决儿科医疗中父母和青少年烟草和电子烟的使用问题 - 一项试点研究
- 批准号:
486580 - 财政年份:2022
- 资助金额:
$ 18.56万 - 项目类别:
Studentship Programs
Co-design of an intervention to address alcohol use among adolescent boys and young men in Tanzania
共同设计一项干预措施,解决坦桑尼亚青春期男孩和年轻男性的饮酒问题
- 批准号:
MR/V032380/1 - 财政年份:2022
- 资助金额:
$ 18.56万 - 项目类别:
Research Grant
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/1 - 财政年份:2021
- 资助金额:
$ 18.56万 - 项目类别:
Research Grant
Application of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care
应用简短的数字筛查工具来解决儿科医疗中父母和青少年烟草和电子烟的使用问题
- 批准号:
455984 - 财政年份:2021
- 资助金额:
$ 18.56万 - 项目类别:
Operating Grants
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/2 - 财政年份:2021
- 资助金额:
$ 18.56万 - 项目类别:
Research Grant
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10057761 - 财政年份:2020
- 资助金额:
$ 18.56万 - 项目类别:
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10213683 - 财政年份:2020
- 资助金额:
$ 18.56万 - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
$ 18.56万 - 项目类别:
Designing targeted interventions to address HIV vulnerabilities and improve clinical outcomes among conflict affected adolescent girls and young women under 25 in Northern Uganda
设计有针对性的干预措施,以解决乌干达北部受冲突影响的少女和 25 岁以下年轻妇女的艾滋病毒脆弱性并改善临床结果
- 批准号:
356145 - 财政年份:2016
- 资助金额:
$ 18.56万 - 项目类别:
Operating Grants














{{item.name}}会员




