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Host Microbe Core

宿主微生物核心

基本信息

批准号：
10237340
负责人：
Lucas R Hoffman
金额：
$ 20.73万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10237340
关键词：
Address Adverse effects Animal Model Animals Antibiotics Area Attention Bacteria Bacteroides Biochemical Biological Assay Biology Cells Cellular biology Clinical Clinical Microbiology Clinical Research Collaborations Communities Consultations Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Disease Disease Outcome Endocrine Endocrine system Epithelial Equipment Escherichia coli Evolution Experimental Designs Fostering Functional disorder Gastrointestinal tract structure Genomics Goals Growth Histocytochemistry Histopathology Facility Image Immune Immune response Immunohistochemistry In Situ Hybridization In Vitro Inflammation Inflammatory Inflammatory Response Infrastructure Investigation Kidney Laboratories Life Expectancy Link Liver Lung Malignant Neoplasms Measures Methods Microbe Microbiology Microscopy Morbidity - disease rate Mucous Membrane National Institute of Diabetes and Digestive and Kidney Diseases Organ Outcome Pancreas Pathogenesis Pathologic Pathology Pharmaceutical Preparations Phenotype Pilot Projects Proteome Proteomics Reagent Renal function Reproducibility Research Research Personnel Research Support Resources Respiratory System Role Sampling Services Slide Specialist Specimen Suggestion Surface Techniques Tissues Training Translational Research Work airway epithelium base behavioral study body system bone clinically relevant cystic fibrosis patients design digital imaging digital pathology digital repositories experience experimental study gastrointestinal gut microbiota improved innovation interest metabolome microbial microbial host microbiome microbiome components next generation novel pathogen pre-clinical research programs ranpirnase targeted imaging tool transcriptome translational approach treatment response vaccine response

项目摘要

ABSTRACT The Host Microbe Core (HMC) will assist and support the research base, trainees, and pilot project investigators by providing specimens, reagents, training, and services to define both the microbial and host response determinants of CF diseases in organs and tissues prioritized by the NIDDK. This Core combines the resources and expertise of specialists in CF basic and clinical microbiology, airway epithelial and immune cell biology, pathology, and microscopy to provide an integrated network of services, reflecting an evolution in the field of CF disease pathogenesis to concurrently investigate the host and pathogens. Core services available to the UW CF P30 research base include: 1. Technical assistance and state-of-the-art facilities for histopathology, immunohistochemistry, in situ hybridization and localization of host and microbial targets, and digital imaging 2. Quantitative digital pathology and whole slide digital repository for pancreata and lungs from people with CF 3. Processing clinical, animal, and laboratory specimens for microbiome, proteome, metabolome, and transcriptome analyses, and for specific targets 4. Microbial culturing of CF specimens in formats representative of CF mucosal conditions for phenotypic, proteomic, genomic, and biochemical analyses 5. Access to strains of bacteria cultured from CF clinical fecal samples, including Escherichia coli and Bacteroides spp. 6. Consultation and training in methods provided by the Core and experimental design 7. Interacting closely with the Clinical and Genomics cores to provide unified services for CF researchers

摘要