Furosemide in severe bronchopulmonary dysplasia: comparative effectiveness of a duration and dosage informed treatment strategy
速尿治疗严重支气管肺发育不良:持续时间和剂量知情治疗策略的比较效果
基本信息
- 批准号:10252762
- 负责人:
- 金额:$ 15.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-04 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdverse effectsAgeAwardBiological AvailabilityBloodBronchopulmonary DysplasiaCaringCessation of lifeChildhoodChronicChronic lung diseaseClinicalClinical InvestigatorClinical PharmacologyClinical ResearchClinical TrialsComplexDataData AnalysesDevelopment PlansDiagnosisDiseaseDiuresisDiureticsDoseDrug KineticsEdemaElectrolytesEnsureEnteralEnvironmentEvaluationExcretory functionExposure toFundingFurosemideGasesGoalsHospitalizationHospitalsHourImpaired cognitionInfantIntravenousKidneyKnowledgeLeadLung diseasesMeasuresMentored Patient-Oriented Research Career Development AwardMentorsMentorshipModelingMorbidity - disease rateMulticenter TrialsNeonatalOxygenPediatric HospitalsPediatricsPennsylvaniaPharmaceutical PreparationsPharmacodynamicsPharmacologyPharmacotherapyPhiladelphiaPhysiologicalPlacebosPlayPopulationPremature BirthPremature InfantProspective cohortPulmonary EdemaPulmonary HypertensionRandomizedRegimenRenal clearance functionResearchResearch ActivityResearch PersonnelRoleRouteSafetyScientistSeriesSeveritiesSeverity of illnessSignal TransductionSpecific qualifier valueStomachSurrogate MarkersTestingTherapeuticTimeTracheostomy procedureTrainingUnited States National Institutes of HealthUniversitiesUrineabsorptionanimal datacareercareer developmentclinical efficacycomorbiditycomparative effectivenessdesigndisability-adjusted life yearsdosageevidence baseexperienceflexibilityhigh risk infantimprovedimproved outcomeinfant outcomeinnovationinstructormedical schoolsmultidisciplinarynext generationototoxicitypatient oriented researchpharmacokinetic modelplacebo controlled trialprematurepressureprimary outcomeprogramsrandomized trialrespiratoryresponsesecondary outcomeskillsstandard carestandard of caretargeted deliverytherapeutic targettreatment durationtreatment strategyurinaryventilationyears of life lost
项目摘要
PROJECT SUMMARY/ABSTRACT
The purpose of this Mentored Patient-Oriented Research Career Development Award (K23) is to
provide Nicolas A. Bamat, MD, MSCE, Instructor of Pediatrics at the Perelman School of Medicine at the
University of Pennsylvania (Penn) and The Children’s Hospital of Philadelphia (CHOP) with the mentorship,
training and research experience needed to become an independent clinical investigator. His long-term career
goal is to improve outcomes for infants with neonatal lung disease by leading trials that identify evidence-
based pharmacotherapeutic practices. His immediate career development goal is to acquire the skills needed
to ensure a successful transition to research independence. To meet this goal, Dr. Bamat and his mentor team
have devised a career development plan that integrates: (1) intensive mentorship from successful pediatric
investigators; (2) focused training in clinical trials, clinical pharmacology and longitudinal data analysis; and (3)
innovative research on furosemide treatment strategies for severe bronchopulmonary dysplasia (BPD).
Complications of preterm birth are the leading pediatric contributor to disability-adjusted life years lost.
BPD, or chronic lung disease of prematurity, is the most common major morbidity. BPD is particularly
devastating for infants with severe BPD (sBPD), the worst severity class. Prolonged initial hospitalizations, co-
morbid pulmonary hypertension, tracheostomy for prolonged ventilation and childhood death are common.
Currently, no pharmacotherapies have proven clinical efficacy for improving respiratory disease course in
sBPD. Despite this, medication exposures are common. The loop diuretic furosemide is most frequently used.
Dr. Bamat’s mentored research will address key knowledge gaps surrounding furosemide use in sBPD. He will:
(1) determine if and when tolerance to furosemide diuresis occurs in sBPD, (2) develop furosemide population
pharmacokinetic models with covariate analysis for individualized dosage regimens, and (3) apply the
knowledge gained in (1) and (2) to determine the comparative effectiveness of an informed furosemide
treatment strategy versus standard of care for improving the respiratory severity score and decreasing the rate
of furosemide-associated adverse effects. This research will be conducted by leveraging the existence of
CHOP’s Chronic Lung Disease Program, a multidisciplinary referral program dedicated to infants with sBPD.
Dr. Bamat’s findings will guide furosemide treatment strategies in sBPD, for testing in placebo-
controlled multicenter trials, funded through R-series awards in his transition to research independence. The
described career development and research activities will occur at Penn and CHOP, an ideal environment in
which to train the next generation of scientists conducting NIH-supported patient-oriented research.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nicolas Augusto Bamat其他文献
Nicolas Augusto Bamat的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nicolas Augusto Bamat', 18)}}的其他基金
Furosemide in severe bronchopulmonary dysplasia: comparative effectiveness of a duration and dosage informed treatment strategy
速尿治疗严重支气管肺发育不良:持续时间和剂量知情治疗策略的比较效果
- 批准号:
10457379 - 财政年份:2020
- 资助金额:
$ 15.83万 - 项目类别:
Furosemide in severe bronchopulmonary dysplasia: comparative effectiveness of a duration and dosage informed treatment strategy
速尿治疗严重支气管肺发育不良:持续时间和剂量知情治疗策略的比较效果
- 批准号:
10677780 - 财政年份:2020
- 资助金额:
$ 15.83万 - 项目类别:
相似海外基金
Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
- 批准号:
10591918 - 财政年份:2023
- 资助金额:
$ 15.83万 - 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
- 批准号:
23K15383 - 财政年份:2023
- 资助金额:
$ 15.83万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
- 批准号:
23H03556 - 财政年份:2023
- 资助金额:
$ 15.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
- 批准号:
23K17212 - 财政年份:2023
- 资助金额:
$ 15.83万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
- 批准号:
22H03519 - 财政年份:2022
- 资助金额:
$ 15.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
- 批准号:
563657-2021 - 财政年份:2022
- 资助金额:
$ 15.83万 - 项目类别:
Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 15.83万 - 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10671022 - 财政年份:2022
- 资助金额:
$ 15.83万 - 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
- 批准号:
10670918 - 财政年份:2022
- 资助金额:
$ 15.83万 - 项目类别:
Adverse Effects of Using Laser Diagnostics in High-Speed Compressible Flows
在高速可压缩流中使用激光诊断的不利影响
- 批准号:
RGPIN-2018-04753 - 财政年份:2022
- 资助金额:
$ 15.83万 - 项目类别:
Discovery Grants Program - Individual