Administrative Core

行政核心

• 批准号: 10261403
• 负责人: ERIC N Olson
• 金额: $ 16.28万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261403
• 关键词: Achievement; Advocate; Applications Grants; Charge; Clinical; Communication; Communities; Duchenne muscular dystrophy; Dystrophin; Ensure; Environment; Family; Fostering; Foundations; Goals; Information Resources; International; Journals; Knowledge; Leadership; Maintenance; Medicine; Methods; Mission; Modern Medicine; Muscle Cells; Muscular Dystrophies; Patient Care; Patients; Public Domains; Public Health; Publishing; Reagent; Research; Research Personnel; Resources; Science; Skeletal Muscle; Training and Education; United States National Institutes of Health; Update; Work; biobank; clinical care; genome editing; innovation; meetings; member; next generation; novel therapeutics; outreach; parent project; regenerative; symposium; web site

Project Summary/Abstract for the Administrative Core The Administrative Core of the UT Southwestern Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center (MDSRC) will be responsible for the management and administration of the overall Center. The primary goal of the Administrative Core is to ensure our Center remains successful in optimizing genome editing or myoediting as a feasible and practical approach to treating Duchenne muscular dystrophy (DMD). Achievement of the Center’s goal will be a transformative moment in modern medicine and will be a significant contribution to the field of muscular dystrophy research as well as to patient care. In order for the UT Southwestern Wellstone MDSRC to remain successful in its scientific endeavors, the Administrative Core will continue to provide leadership amongst the various investigators within the Center in order to ensure efficient use of resources and the successful completion of the goals outlined in this NIH P50 Grant Application. The Administrative Core will provide an environment to facilitate the sharing and exchange of ideas and discoveries within the Center as well as with the scientific community at-large. The Center will also actively seek to disseminate these discoveries to patients and their families. The nurturing environment that exists at UT Southwestern will foster the training and education of the next generation of clinical and scientific investigators in the field of muscular dystrophy research. Finally, the UT Southwestern Administrative Core will continue its effective communication with the NIH and Wellstone Network Consortium in order to collectively advance the field of muscular dystrophy research forward. The goals set out by the Administrative Core will be accomplished by pursuing the following three specific aims: Specific Aim 1: To facilitate and enhance clinical and scientific interactions within the UT Southwestern Wellstone Muscular Dystrophy Specialized Research Center. Specific Aim 2: To promote the dissemination of knowledge, resources, and discoveries related to genome editing and Duchenne muscular dystrophy. Specific Aim 3: To serve as an advocate for and promote outreach to muscular dystrophy patients and their families regarding novel therapeutics and advances in clinical care. Under the continued effective leadership of the Administrative Core, the UT Southwestern Senator Paul D. Wellstone MDSRC will strive to achieve its overarching goal of optimizing genome editing to be an effective method of permanently restoring dystrophin expression within myocytes and thus provide a long awaited therapy for DMD. Thus, the proposed NIH P50 Grant Application is relevant to and in keeping with the mission of the NIH.

行政核心的项目摘要/摘要 UT西南参议员Paul D. Wellstone肌肉营养不良的行政核心专业 研究中心（MDSRC）将负责整个中心的管理和管理。 行政核心的主要目标是确保我们的中心在优化基因组方面保持成功 编辑或肌编辑是一种可行且实用的方法，用于治疗Duchenne肌肉营养不良（DMD）。 实现中心目标将是现代医学中的变革时刻，将是一个重要的 对肌肉营养不良研究以及患者护理领域的贡献。为了ut 西南Wellstone MDSRC将在其科学努力中取得成功，行政核心将 继续在中心内的各个调查员之间提供领导才能，以确保有效 资源的使用以及在此NIH P50赠款申请中概述的目标的成功完成。这 行政核心将提供一个环境，以促进共享和交流思想和发现 在中心以及一般的科学界。该中心还将积极寻求 向患者及其家人传播这些发现。 UT存在的培养环境 西南部将培养下一代临床和科学研究人员的培训和教育 在肌肉营养不良研究的领域。最后，UT西南行政核心将继续 与NIH和Wellstone网络财团的有效沟通，以共同促进 肌肉营养不良研究的领域。行政核心设定的目标将是 通过追求以下三个特定目标来完成：具体目标1：促进和增强临床 以及UT西南Wellstone肌肉营养不良专业研究中的科学互动 中心。特定目的2：促进与知识，资源和发现相关的发现的传播 基因组编辑和Duchenne肌肉营养不良。特定目标3：作为倡导者和促进 向肌肉营养不良患者及其家人推广有关新疗法和进步的进展 临床护理。在行政核心的持续有效领导下，UT西南部 参议员Paul D. Wellstone MDSRC将努力实现其优化基因组编辑的总体目标 成为永久恢复肌细胞内肌营养不良蛋白表达的有效方法，从而提供 长期以来对DMD的疗法。这是拟议的NIH P50赠款申请与 随着NIH的任务。