Developmental Core

发展核心

• 批准号: 10593147
• 负责人: JONATHAN E. GOLUB
• 金额: $ 28.78万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-16 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593147
• 关键词: Accountability; Address; Adherence; Applications Grants; Area; Arts; Award; Basic Science; Bioinformatics; Clinical Research; Collaborations; Communities; Dedications; Development; Discipline; Discipline of Nursing; Educational workshop; Engineering; FAIR principles; Faculty; Feedback; Funding; Future; Goals; Grant; Grant Review; Health; Health Services Accessibility; Human; Immunologist; Individual; Infection Control; Infection prevention; Investments; K-Series Research Career Programs; Knowledge; Leadership; Mentors; Mentorship; Methodology; Mission; Modeling; Nursing Models; Outcomes Research; Pathogenesis; Prevention; Productivity; Public Health; Research; Research Methodology; Research Personnel; Research Priority; Resources; Science; Scientist; Series; Study Section; Systems Biology; Training; Translations; Universities; Work; Writing; career; career development; clinical investigation; co-infection; community based participatory research; comorbidity; cost effectiveness; high risk; implementation science; innovation; interest; mHealth; medical schools; meetings; molecular diagnostics; multidisciplinary; next generation; novel; novel strategies; programs; recruit; skills; therapeutic vaccine; training opportunity

ABSTRACT – JHU TRAC DEVELOPMENTAL CORE (DC) The mission of the Developmental Core (DC) is to support and mentor the next generation of TB researchers and to recruit new TB investigators to increase the diversity and breadth of TB scientists at Johns Hopkins University (JHU). Early Stage Investigators (ESI) need to integrate a variety of disciplines into their work, and innovative leaders in other fields need to be brought into the TB research fold to generate transformational gains in basic and clinical research, translation, and implementation. Despite the productivity and accomplishments of the JHU faculty, nurturing and sustaining a pipeline of New Investigators (NI) who can provide leadership and innovation in the future is extremely challenging. Without dedicated resources to support NI and ESI, many trainees move onto other fields. There is a recognized need for seed funding, core resources, and intensive mentoring for new researchers, who also would benefit from broadened skill sets beyond their primary training. The DC will seek to draw from areas of underrepresented science and scientists, including opportunities for future research/training. Fields such as systems biology in TB are lacking; thus, we will seek to bring in computational modelers, bioinformaticians, and immunologists to fill this void. Novel approaches to understanding TB pathogenesis are needed, with implications for molecular diagnostics, therapeutic vaccines, and host-directed therapies. Nursing models to increase prevention, access to treatment, retention and human- centered adherence models, as well as infection control and prevention science are recognized areas needing TB outsiders. Finally, engagement of stakeholders in community-based participatory research methods is increasingly needed in TB control globally. The overall goals of the JHU TRAC DC are to support the highest priority innovative, cross-disciplinary TB research, to support and mentor ESI in team science, and to recruit and support NI to TB. Developmental Awards provided by the DC will provide both ESI and established investigators not currently involved in TB research with the opportunity to stimulate innovative ideas and to receive support for fruitful new areas of interdisciplinary, collaborative research. A special focus of the DC will be the recruitment and career development of Investigators among groups nationally underrepresented in health-related research (UHRR). In addition to the Developmental Awards, the Developmental Core will augment individual mentorship with Internal Scientific Reviews of grant proposals, including specific aims reviews; TRAC-specific Writing Accountability Groups (WAGs), a TRAC K- Club to support development of K01, K08, K23, or K99 applications, and a TRAC K2R Club for investigators transitioning from K awards to R01 grants. The Developmental Core will work with the Administrative Core to facilitate exchange of ideas and methodologies through a weekly TRAC Seminar Series, research-in-progress meetings, workshops, and the annual JHU TB Scientific Meeting and TRAC Data Fair.

摘要 - JHU TRAC发育核心（DC） 发展核心（DC）的使命是支持和指导下一代结核病研究人员 并招募新的结核病调查员，以增加约翰·霍普金斯（Johns Hopkins）的结核病科学家的多样性和广度 大学（JHU）。早期研究人员（ESI）需要将各种学科融入他们的工作，并且 需要将其他领域的创新领导者带入结核病研究范围，以产生变革的收益 在基础和临床研究，翻译和实施中。尽管有生产力和成就 JHU教师，培育和维持新调查人员（NI）的管道，他们可以提供领导和 未来的创新极为挑战。没有专门的资源来支持NI和ESI，许多 实习生移至其他领域。公认的需要种子资金，核心资源和密集 为新研究人员提供指导，他们也将从主要培训以外的扩大技能中受益。 DC将寻求从代表性不足的科学和科学家领域中汲取灵感，包括 未来的研究/培训。缺乏结核病系统生物学等领域。因此，我们将寻求带来 计算建模者，生物信息学家和免疫学家填补这一空白。新颖的方法 需要了解结核病发病机理，对分子诊断，治疗疫苗有影响 和主机定向疗法。护理模型以增加预防，获得治疗，保留和人类的预防模型 集中的依从性模型以及感染控制和预防科学是公认的领域需求 结核病局外人。最后，利益相关者参与基于社区的参与研究方法是 全球结核病控制越来越需要。 JHU TRAC DC的总体目标是支持最高优先级创新的跨学科结核 研究，支持团队科学中的ESI，并招募和支持NI到结核病。发展奖 由DC提供 刺激创新思想并获得支持富有成果的跨学科新领域的机会， 协作研究。 DC的特别重点将是调查人员的招聘和职业发展 在与健康相关的研究（UHRR）的全国人数不足的群体中。除了发展 奖项，发展核心将通过内部科学评论来增强个人心态 建议，包括特定的目标评论；特定特异性写作问责组（WAGS），trac k- 支持开发K01，K08，K23或K99应用程序的俱乐部，以及针对调查人员的TRAC K2R俱乐部 从K奖项过渡到R01赠款。发展核心将与行政核心合作 通过每周的TRAC研讨会系列促进思想和方法的交换 会议，讲习班以及年度JHU结核病科学会议和TRAC数据博览会。