Persistent Functional Immune Defects in Treated HIV Infection
HIV感染治疗后持续存在功能性免疫缺陷
基本信息
- 批准号:10593968
- 负责人:
- 金额:$ 18.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-07 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS clinical trial groupAcquired Immunodeficiency SyndromeAddressAdipose tissueAgingAnti-Inflammatory AgentsAutomobile DrivingAwardBlood VesselsCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCaliforniaCardiovascular systemCellsCessation of lifeClinicalCytomegalovirusDataDedicationsDefectDiabetes MellitusDiseaseEducational workshopEnvironmentEpithelial CellsEtiologyEventExhibitsFoundationsFrequenciesFundingGrantHIVHIV InfectionsHIV SeropositivityHeart DiseasesImmuneImmunologic Deficiency SyndromesImmunologicsImpairmentIndividualInflammationInflammatoryInsulin ResistanceInternationalInterventionK-Series Research Career ProgramsLaboratoriesLife ExpectancyLinkMalignant neoplasm of lungMediatingMedicineMentored Research Scientist Development AwardMentorsMentorshipMid-Career Clinical Scientist Award (K24)ModernizationMorbidity - disease rateNon-Insulin-Dependent Diabetes MellitusOrganPathway interactionsPeer ReviewPeptidesPersonsPhasePhysiciansPlacebosPopulationProcessProductivityPublicationsRandomized, Controlled TrialsRecoveryReportingResearchResearch InstituteResearch PersonnelResearch TrainingRiskRoleSan FranciscoScienceScientistSecureSeriesSmokingSubstance Use DisorderT cell infiltrationT-Cell ActivationT-LymphocyteTNF geneTimeTrainingTraining ActivityTraining ProgramsUniversitiesValganciclovirVascular DiseasesVascular EndotheliumViralantiretroviral therapybasecardiometabolismcareercareer developmentco-infectioncohortcollaboratorydisorder riskgastrointestinal epitheliumhigh riskimmune activationimprovedindexinginflammatory markerinhibitorinterestlifestyle factorsmicrobialmid-career facultymortalitymultidisciplinarypatient oriented researchprogramsskillsskills trainingsystemic inflammatory response
项目摘要
Project Summary
Peter Hunt, MD is an Associate Professor of Medicine in the UCSF Division of Experimental Medicine and an
internationally recognized leader in translational Patient-Oriented Research (POR) focused on the causes and
consequences of immune activation in treated HIV infection. He is submitting this K24 Mid-Career
Development application to afford him protected time to mentor junior investigators, to provide him with
dedicated mentorship skills training, and to continue to grow his POR program. The candidate: This proposal
will build upon Dr. Hunt's highly productive research program, exemplified by over 200 peer-reviewed
publications, a citation h-index of 52, and robust research funding base including three R01 grants and two
large projects in the DARE collaboratory and amfAR Institute for HIV Cure Research. He has already
demonstrated a strong track record for mentoring, particularly in multidisciplinary team science, including 4
mentees who have successfully applied for K23/K01 awards, and two who have gone on to secure
independent R-series grants. He is also the recipient of the 2015 UCSF AIDS Research Institute Award for
Mentoring. The environment: He has a rich foundation for supporting his mentees including access to the
UCSF SCOPE cohort of >2000 HIV-infected individuals in San Francisco and connections to several other
multicenter cohorts (LSOCA, UARTO, CNICS) and research networks including the ACTG, where he served
as Chair of the Inflammation and End Organ Disease Committee. Mentorship training: This K24 award will
further enhance his mentorship skills through intensive workshops and training modules supported by the
UCSF CTSI Mentorship Training Program and the UCSF-GIVI Mentoring the Mentors program. He will also be
coached by a robust group of career mentors as he navigates this next phase of his career. Research plan:
The overarching hypothesis motivating the research plan is that subclinical immunodeficiency despite treated
HIV infection decreases CD8+ T cell-mediated CMV surveillance, which in turn leads to microbial translocation
and cardiometabolic complications. The specific aims will: 1) assess the contribution of asymptomatic CMV
replication to soluble markers of microbial translocation and vascular dysfunction in treated HIV infection, 2)
assess the degree to which treated HIV infection is associated with inflammatory CMV-specific CD8+ T cell
infiltration of adipose tissue and insulin resistance, and 3) assess whether maturational defects in CMV-specific
CD8+ T cells occur in treated HIV infection. These studies will also serve as ideal POR training platforms for
his mentees.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PETER W HUNT其他文献
PETER W HUNT的其他文献
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{{ truncateString('PETER W HUNT', 18)}}的其他基金
Impact of Treating Asymptomatic CMV Replication on Cardiovascular Risk in Treated HIV Infection
治疗无症状 CMV 复制对 HIV 感染治疗者心血管风险的影响
- 批准号:
10715847 - 财政年份:2023
- 资助金额:
$ 18.43万 - 项目类别:
Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV
评估艾滋病毒感染者代谢健康中脂肪组织产热与纤维化之间的相互关系
- 批准号:
10626188 - 财政年份:2022
- 资助金额:
$ 18.43万 - 项目类别:
Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV
巨细胞病毒 (CMV)、HIV 的肠道屏障和免疫功能障碍
- 批准号:
10177602 - 财政年份:2021
- 资助金额:
$ 18.43万 - 项目类别:
Plasma Proteomic and Metabolomic Predictors of Vascular Disease in Treated HIV
HIV治疗者血管疾病的血浆蛋白质组学和代谢组学预测因子
- 批准号:
10331583 - 财政年份:2021
- 资助金额:
$ 18.43万 - 项目类别:
Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV
巨细胞病毒 (CMV)、HIV 的肠道屏障和免疫功能障碍
- 批准号:
10875189 - 财政年份:2021
- 资助金额:
$ 18.43万 - 项目类别:
Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV
巨细胞病毒 (CMV)、HIV 的肠道屏障和免疫功能障碍
- 批准号:
10372191 - 财政年份:2021
- 资助金额:
$ 18.43万 - 项目类别:
Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV
巨细胞病毒 (CMV)、HIV 的肠道屏障和免疫功能障碍
- 批准号:
10578682 - 财政年份:2021
- 资助金额:
$ 18.43万 - 项目类别:
Impact of Treating Asymptomatic CMV Replication on Cardiovascular Risk in Treated HIV Infection
治疗无症状 CMV 复制对 HIV 感染治疗者心血管风险的影响
- 批准号:
10242227 - 财政年份:2020
- 资助金额:
$ 18.43万 - 项目类别:
Persistent Functional Immune Defects in Treated HIV Infection
HIV感染治疗后持续存在功能性免疫缺陷
- 批准号:
9927206 - 财政年份:2020
- 资助金额:
$ 18.43万 - 项目类别:
Impact of Treating Asymptomatic CMV Replication on Cardiovascular Risk in Treated HIV Infection
治疗无症状 CMV 复制对 HIV 感染治疗者心血管风险的影响
- 批准号:
10449260 - 财政年份:2020
- 资助金额:
$ 18.43万 - 项目类别:
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