Core C: Data

核心C：数据

• 批准号: 10593849
• 负责人: Sheng Chih Jin
• 金额: $ 13.97万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593849
• 关键词: American; Anatomy; Bioinformatics; Cells; Collaborations; Communities; Community Developments; Complex; Complex Analysis; Data; Data Analyses; Data Management Resources; Data Security; Data Set; Data Storage and Retrieval; Deposition; Electrophysiology (science); Ensure; Experimental Designs; Fostering; Genes; Genomics; Goals; Human; Individual; Knowledge; Medical; Metadata; Methodology; Multiomic Data; Neuroglia; Neuroma; Neurons; Pain; Pain Clinics; Pain Research; Pain management; Pathologic; Pathway interactions; Peripheral Nerves; Peripheral Nervous System; Peripheral Nervous System Diseases; Physiological; Property; Proteomics; Quality Control; Research; Research Personnel; Resources; Role; Secure; Services; Site; Small Nuclear RNA; Spinal Ganglia; Statistical Data Interpretation; System; Therapeutic; Therapeutic Uses; Time; Tissues; Validation; Vertebral column; cell type; chronic pain; chronic pain patient; chronic painful condition; computerized data processing; data curation; data dissemination; data ecosystem; data management; data quality; data standards; data submission; design; experience; genome sequencing; innovation; member; multiple omics; new therapeutic target; novel therapeutics; patch sequencing; research and development; success; therapeutic development; therapeutic target; transmission process; whole genome

Abstract – Data Core The primary purpose of the Data core is to collect, store, coordinate, and transfer all data, metadata, and analysis strategies generated within the U19 center (the INTERCEPT pain center) to the U24 DCIC and the HEAL Platform. The Data core will conduct multiple inter-disciplinary genomic and statistical analyses to study and integrate the multi-level omics data obtained from the three individual component projects of the INTERCEPT Center. The INTERCEPT Center projects involve extensive data management and complex analyses. Such analyses require organized and simultaneous consideration of data from different component projects, and demand robust and innovative integrated analysis methodology. The Data core provides the required data management and coordination function, as well as the bioinformatic expertise and innovative integrated genomic analysis to enable the success of the INTERCEPT Center. The main objective of the Data core is to serve as a backbone support resource for experimental design refinement, data quality control, management, integration, analyses, and interpretation, and serve as a central hub to foster data and information exchange and collaboration between individual projects and cores in the INTERCEPT Center. Built upon the Core members’ close and long-time collaboration and extensive experience in multi-omics data analyses, this Data core will provide essential services through the following specific aims: 1) Provide central data storage, management, and information security services to all researchers within the U19 Center and ensure the timely submission of data and data analyses to the HEAL Platform. 2) Integrated multi-omic characterization of the peripheral nervous system to identify spatially resolved cells, genes, and pathways associated with pain conditions.

摘要-数据核心 数据核心的主要目的是收集、存储、协调和传输所有数据、元数据和 在U19中心（INTERCEPT疼痛中心）内生成的分析策略到U24 DCIC和 HEAL平台。数据核心将进行多学科基因组和统计分析， 并整合从三个单独的组成项目中获得的多层次组学数据， 拦截中心。拦截中心项目涉及广泛的数据管理和复杂的 分析。这种分析需要有组织地同时考虑来自不同组成部分的数据 项目，并要求强大的和创新的综合分析方法。数据核心提供了 所需的数据管理和协调功能，以及生物信息学专业知识和创新 整合的基因组分析，使拦截中心的成功。数据的主要目的 核心是作为实验设计细化、数据质量控制 管理、集成、分析和解释，并作为促进数据和 INTERCEPT中心的各个项目和核心之间的信息交换和协作。建造 基于核心成员在多组学数据方面的长期密切合作和丰富经验， 分析，这个数据核心将通过以下具体目标提供基本服务：1）提供中央 为U19中心内的所有研究人员提供数据存储、管理和信息安全服务， 确保及时向HEAL平台提交数据和数据分析。2)集成多组学 表征周围神经系统，以识别空间分辨的细胞、基因和通路 与疼痛状况有关。