Nonhuman Primate Core Humoral Immunology Laboratory for AIDS Vaccine Research and Development

非人灵长类艾滋病疫苗研发核心体液免疫学实验室

• 批准号: 10596971
• 负责人: SHAUNNA SHEN
• 金额: $ 266.63万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-30 至 2023-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10596971
• 关键词: AIDS Vaccines; Acquired Immunodeficiency Syndrome; Animals; Biological Assay; Contractor; Contracts; Detection; Ensure; Epidemic; HIV; HIV vaccine; HIV/SIV vaccine; Immune response; Immunization; Immunize; Immunologic Tests; Immunologics; Immunology; Infection; Infection prevention; Laboratories; Lead; Mission; Modeling; National Institute of Allergy and Infectious Disease; Neutralizing antibody assay; Prevention strategy; Reproducibility; Research Personnel; Research Support; SIV; SIV Vaccines; Site; Standardization; Testing; United States National Institutes of Health; Virus; Virus Replication; immunogenicity; improved; nonhuman primate; pre-clinical; research and development; simian human immunodeficiency virus; therapy development; vaccine evaluation; vaccine strategy; virology

The mission of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID) is to ensure an end to the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic by supporting research that can lead to the development of therapies, vaccines, and prevention strategies. Nonhuman primate (NHP) models present the opportunity to test a variety of candidate AIDS vaccines, optimizing their ability to elicit immune responses and testing their ability to prevent infection or to control virus replication after virus challenge. DAIDS provides immunological and virological support for NHP studies conducted at NIAID’s Simian Vaccine Evaluation Unit (SVEU) contract sites and by AIDS vaccine researchers through three Nonhuman Primate Immunology and Virology Laboratories for AIDS Vaccine Research and Development (NHP Core Labs) contracts. The objective of these Core Laboratories has been to ensure standardization and comparability of the assays conducted for preclinical NHP studies and to provide a common basis for assessment of the immunogenicity and efficacy of candidate HIV and SIV vaccines.

国家过敏和传染病研究所艾滋病司的使命是通过支持可导致开发治疗方法、疫苗和预防战略的研究，确保结束人体免疫缺陷病毒/获得性免疫缺陷综合症（艾滋病毒/艾滋病）的流行。 非人灵长类动物（NHP）模型提供了测试各种候选艾滋病疫苗的机会，优化它们引发免疫应答的能力，并测试它们在病毒攻击后预防感染或控制病毒复制的能力。 DAIDS为在NIAID的猿猴疫苗评估单位（SVEU）合同地点进行的NHP研究提供免疫学和病毒学支持，并由艾滋病疫苗研究人员通过三个非人灵长类动物免疫学和病毒学实验室进行艾滋病疫苗研究和开发（NHP核心实验室）合同。 这些核心实验室的目标是确保临床前NHP研究所进行的试验的标准化和可比性，并为评估候选HIV和SIV疫苗的免疫原性和有效性提供共同基础。