Suubi+Adherence-R2: Examining the longitudinal HIV treatment adherence among youth living with HIV (YLHIV) transitioning into young adulthood

Suubi Adherence-R2：检查青年艾滋病毒感染者 (YLHIV) 过渡到成年早期的纵向艾滋病毒治疗依从性

• 批准号: 10594195
• 负责人: FRED M SSEWAMALA
• 金额: $ 30.12万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594195
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Administrative Supplement; Adult; Area; Attention; Caring; Communities; Conflict (Psychology); Decision Making; Disease; Drug Prescriptions; Economics; Exposure to; Forcible intercourse; HIV; HIV Infections; High Prevalence; Human immunodeficiency virus test; Infection; Knowledge; Language; Life; Mental Health; Mental disorders; Parents; Participant; Pharmaceutical Preparations; Population; Poverty; Prevalence; Privacy; Public Health; Refugees; Reproductive Health; Research; Research Priority; Risk; Savings; Self Efficacy; Sexual Health; Social support; Target Populations; Transportation; Trauma; Uganda; United States National Institutes of Health; Viral; Vulnerable Populations; War; Youth; antiretroviral therapy; behavioral adherence; cognitive function; gender-based violence; high risk sexual behavior; literacy; parent grant; primary outcome; psychologic; recruit; sexual risk taking; social stigma; substance using adolescents; transmission process; trauma exposure; treatment adherence; weapons; young adult

PROJECT SUMMARY/ABSTRACT The purpose of the Suubi+Adherence-R2 administrative supplemental project is to enhance inclusion of the target population by recruiting refugee youth living with HIV (RYLHIV) in Uganda. While the parent grant focuses on youth living with HIV, it does not include refugee youth population. Yet, refugee youth are a very vulnerable population at increased risk of HIV infection due to exploitation as many of them may be unaccompanied by parents or guardians and many have been exposed to gender-based violence including rape that is used as a weapon of war in the conflicts they are fleeing from. Moreover, many of these refugees are now settled in areas with some of the highest HIV rates in Uganda. This elevated risk of HIV infection among the refugee population is compounded by the fact that many of these refugee youth have very limited knowledge about sexual and reproductive health in general. Additionally, HIV testing rates are low in these refugee communities due to barriers such as lack of privacy from overcrowding in camps, transportation difficulties, literacy and language difficulties, stigma, and HIV testing is often not the top priority as refugees are preoccupied by activities necessary for basic survival. Additionally, given the high prevalence of trauma-associated mental disorders due to their exposure to trauma, compounded by the abject poverty that they have been thrown into by displacement, that have been shown to increase the rates of engagement in risky sexual behavior and substance use, these adolescent refugees are at especially increased risk of acquiring or transmitting HIV and other STIs. Consistent with the aims of the parent grant, the administrative supplement will allow us to: examine the HIV viral suppression (primary outcome) and explore the participants' ability to access and refill prescribed medication, adhere to prescribed daily medication routines, and engage in HIV care; and (2) assess a) economic stability, sexual risk- taking behavior, adherence self-efficacy; b) cognitive functioning; c) mental health functioning; and d) young adult transitions and social support. This administrative supplement is significant because it has the potential to advance our understanding of factors including utilization of HIV treatment and adherence to treatment, trauma-associated disorders, psychological functioning, and sexual decision-making among vulnerable refugee youth population in Uganda.

项目总结/摘要 Suubi+Adherence-R2行政补充项目的目的是增强 通过在乌干达招募感染艾滋病毒的难民青年（RYLHIV），将目标人群纳入其中。 虽然父母补助金的重点是感染艾滋病毒的青年，但不包括难民青年 人口然而，难民青年是一个非常脆弱的群体，感染艾滋病毒的风险增加 由于受到剥削，许多儿童可能没有父母或监护人陪伴， 遭受基于性别的暴力，包括被用作战争武器的强奸， 他们逃离的冲突。此外，这些难民中的许多人现在定居在 艾滋病感染率在乌干达是最高的艾滋病毒感染的风险增加， 难民人口是复杂的事实，许多这些难民青年有非常有限的 了解性健康和生殖健康的一般知识。此外，艾滋病毒检测率 在这些难民社区，由于缺乏隐私， 难民营，交通困难，识字和语言困难，耻辱和艾滋病毒检测是 这往往不是最优先事项，因为难民忙于基本生存所需的活动。 此外，鉴于创伤相关精神障碍的高患病率， 遭受创伤，再加上他们被投入的赤贫， 流离失所，已被证明会增加从事危险性行为的比率， 和物质使用，这些青少年难民获得或 传播艾滋病毒和其他性传播感染。根据父母补助金的目的， 补充将使我们能够：检查HIV病毒抑制（主要结局），并探索 参与者获取和补充处方药物的能力，坚持每日处方 药物常规，并从事艾滋病毒护理;和（2）评估a）经济稳定性，性风险- 采取行为、坚持自我效能、B）认知功能、c）心理健康功能; （d）年轻人的过渡和社会支持。这一行政补充意义重大 因为它有可能促进我们对艾滋病毒利用等因素的理解 治疗和坚持治疗，创伤相关疾病，心理功能， 在乌干达脆弱的难民青年人口中进行性和性决策。