Instructive Signals for Motor Learning

项目摘要 元学习是指学会学习的能力。尽管我们在理解 学习的神经机制，元学习的神经机制是一个谜。该项目将 研究元学习的候选突触机制。使用集成的分子、细胞、系统和 行为神经科学的方法，拟议的研究将测试的假设，时间规则 控制突触可塑性的神经元是后天习得的。初步结果表明， 小脑中的关联突触可塑性可以通过经验自适应地调整，以解决 理论家们称之为临时信用分配问题，精确地补偿了反馈中的延迟 关于行为错误，所以只有在错误产生的时候活跃的突触 在学习过程中会弱化。如果得到证实，这将代表算法的一个新维度， 神经回路用于通过经验调整自己的性能，具有广泛的科学和临床意义。 影响

PROJECT SUMMARY Meta-learning refers to the ability to learn to learn. Whereas much progress has been made in understanding the neural mechanisms of learning, the neural mechanisms of meta-learning are a mystery. This project will investigate a candidate synaptic mechanism of meta-learning. Using integrated molecular, cellular, systems, and behavioral neuroscience approaches, the proposed research will test the hypothesis that the timing rules governing synaptic plasticity are themselves learned. Preliminary results suggest that the timing rules for associative synaptic plasticity in the cerebellum can be adaptively tuned though experience to solve what theorists have called the temporal credit assignment problem, precisely compensating for delays in the feedback about behavioral errors, so that only synapses that were active around the time that an error was generated undergo weakening during learning. If confirmed, this would represent a new dimension of the algorithms that neural circuits use to tune their own performance through experience, with broad scientific and clinical implications.