A prospective multiethnic HFpEF cohort from California's Central Valley

来自加州中央山谷的前瞻性多种族 HFpEF 队列

• 批准号: 10599613
• 负责人: Martin Cadeiras
• 金额: $ 9.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599613
• 关键词: Administrative Supplement; Award; Bioinformatics; Biological Markers; Biological Testing; California; Climate; Clinical; Complement; Diabetes Mellitus; Diet; EFRAC; Ensure; Environment; Failure; Fostering; Funding; Goals; Grant; Health; Heart failure; Hispanic; Hypertension; Inflammation; Intervention; Life Style; Medical; Mentors; Molecular; Morphology; Obesity; Outcome; Parents; Patients; Physical activity; Physicians; Prevalence; Request for Applications; Research; Risk Factors; Scientist; Services; Social Environment; Training; United States National Institutes of Health; career; career development; cohort; experience; improved; individualized medicine; insight; multi-ethnic; parent grant; preservation; prospective; underserved community

ABSTRACT This is an application requesting for an Administrative Supplement to Enhance Diversity for the NIH U01 HL160274 grant. The proposed combined clinical and bioinformatics studies, although within the scope of the parent grant, are not in the funded Specific Aims. The long-term goal of the candidate is to pursue a career as a physician-scientist with a focus on servicing underserved communities. This supplement aims to obtain new insights on how exposomic factors correlate to heart failure with preserved ejection fraction (HFpEF) risk factors by building upon the existing aims from the parent award. Specifically, the proposed study aims to use the increased prevalence of diabetes, hypertension, and obesity observed in Hispanic patients, and their corresponding exposomic factors – including climate, environment, diet and lifestyle, medical interventions, body morphology, physical activity, and inflammation – to test the biological markers of HFpEF with their associated socioenvironmental determinants. By understanding the exposomic factor contributions, we will gain insights into patient-specific treatment to improve their long-term health outcomes. The candidate and the mentors have outlined a comprehensive training goal and have assembled a strong Mentoring Team to ensure that the candidate will receive valuable technical training, research experience, and career development. Therefore, this proposed supplement will provide the candidate a platform for career development while, in parallel, fostering diversity by reducing underrepresentation in the workforce of scientific research, as outlined in the FOA (PA-18-906). New insights obtained from the proposed supplement will highly complement and enhance the project in the parent grant.

抽象的 这是一项要求提供行政补充的申请，以增强NIH U01的多样性 HL160274赠款。拟议的临床和生物信息学研究合并，尽管在 父母赠款不在基本的特定目标中。候选人的长期目标是从事职业 一个身体科学家，专注于为服务不足的社区提供服务。这种补充旨在获得新的 有关释放因素如何与心力衰竭与保留的射血分数（HFPEF）风险相关的见解 通过基于父母奖的现有目标来建立因素。具体而言，拟议的研究旨在使用 西班牙裔患者观察到的糖尿病，高血压和肥胖症的患病率增加 相应的外交因素 - 包括气候，环境，饮食和生活方式，医疗干预措施， 身体形态，体育活动和炎症 - 测试HFPEF的生物学标志物 相关的社会环境决定者。通过了解胚房因素的贡献，我们将 了解特定于患者的治疗以改善其长期健康结果。候选人和 导师概述了一个全面的培训目标，并组建了一个强大的指导团队，以确保 候选人将获得宝贵的技术培训，研究经验和职业发展。 因此，该提议的补充剂将为候选人提供职业发展的平台，同时 并行，通过减少科学研究劳动力中的人数不足来促进多样性，如概述 在FOA（PA-18-906）中。从拟议的补充剂获得的新见解将高度完成，并且 增强父母赠款中的项目。