A prospective multiethnic HFpEF cohort from California's Central Valley

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ABSTRACT This is an application requesting for an Administrative Supplement to Enhance Diversity for the NIH U01 HL160274 grant. The proposed combined clinical and bioinformatics studies, although within the scope of the parent grant, are not in the funded Specific Aims. The long-term goal of the candidate is to pursue a career as a physician-scientist with a focus on servicing underserved communities. This supplement aims to obtain new insights on how exposomic factors correlate to heart failure with preserved ejection fraction (HFpEF) risk factors by building upon the existing aims from the parent award. Specifically, the proposed study aims to use the increased prevalence of diabetes, hypertension, and obesity observed in Hispanic patients, and their corresponding exposomic factors – including climate, environment, diet and lifestyle, medical interventions, body morphology, physical activity, and inflammation – to test the biological markers of HFpEF with their associated socioenvironmental determinants. By understanding the exposomic factor contributions, we will gain insights into patient-specific treatment to improve their long-term health outcomes. The candidate and the mentors have outlined a comprehensive training goal and have assembled a strong Mentoring Team to ensure that the candidate will receive valuable technical training, research experience, and career development. Therefore, this proposed supplement will provide the candidate a platform for career development while, in parallel, fostering diversity by reducing underrepresentation in the workforce of scientific research, as outlined in the FOA (PA-18-906). New insights obtained from the proposed supplement will highly complement and enhance the project in the parent grant.