A prospective multiethnic HFpEF cohort from California's Central Valley

来自加州中央山谷的前瞻性多种族 HFpEF 队列

• 批准号: 10599613
• 负责人: Martin Cadeiras
• 金额: $ 9.23万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599613
• 关键词: Administrative Supplement; Award; Bioinformatics; Biological Markers; Biological Testing; California; Climate; Clinical; Complement; Diabetes Mellitus; Diet; EFRAC; Ensure; Environment; Failure; Fostering; Funding; Goals; Grant; Health; Heart failure; Hispanic; Hypertension; Inflammation; Intervention; Life Style; Medical; Mentors; Molecular; Morphology; Obesity; Outcome; Parents; Patients; Physical activity; Physicians; Prevalence; Request for Applications; Research; Risk Factors; Scientist; Services; Social Environment; Training; United States National Institutes of Health; career; career development; cohort; experience; improved; individualized medicine; insight; multi-ethnic; parent grant; preservation; prospective; underserved community

ABSTRACT This is an application requesting for an Administrative Supplement to Enhance Diversity for the NIH U01 HL160274 grant. The proposed combined clinical and bioinformatics studies, although within the scope of the parent grant, are not in the funded Specific Aims. The long-term goal of the candidate is to pursue a career as a physician-scientist with a focus on servicing underserved communities. This supplement aims to obtain new insights on how exposomic factors correlate to heart failure with preserved ejection fraction (HFpEF) risk factors by building upon the existing aims from the parent award. Specifically, the proposed study aims to use the increased prevalence of diabetes, hypertension, and obesity observed in Hispanic patients, and their corresponding exposomic factors – including climate, environment, diet and lifestyle, medical interventions, body morphology, physical activity, and inflammation – to test the biological markers of HFpEF with their associated socioenvironmental determinants. By understanding the exposomic factor contributions, we will gain insights into patient-specific treatment to improve their long-term health outcomes. The candidate and the mentors have outlined a comprehensive training goal and have assembled a strong Mentoring Team to ensure that the candidate will receive valuable technical training, research experience, and career development. Therefore, this proposed supplement will provide the candidate a platform for career development while, in parallel, fostering diversity by reducing underrepresentation in the workforce of scientific research, as outlined in the FOA (PA-18-906). New insights obtained from the proposed supplement will highly complement and enhance the project in the parent grant.

抽象的 这是一份请求行政补充以增强 NIH U01 多样性的申请 HL160274 拨款。拟议的结合临床和生物信息学研究，尽管在范围内 家长补助金，不属于资助的具体目标。候选人的长期目标是追求以下职业： 一位专注于为服务不足的社区提供服务的医师科学家。本补充旨在获得新的 关于暴露因素如何与射血分数保留的心力衰竭 (HFpEF) 风险相关的见解 以母公司奖项的现有目标为基础来考虑因素。具体来说，拟议的研究旨在使用 西班牙裔患者中糖尿病、高血压和肥胖症患病率的增加及其 相应的暴露因素——包括气候、环境、饮食和生活方式、医疗干预、 身体形态、体力活动和炎症——用它们来测试 HFpEF 的生物标志物 相关的社会环境决定因素。通过了解暴露因素的贡献，我们将 深入了解患者的具体治疗，以改善他们的长期健康结果。候选人和 导师们制定了全面的培训目标，并组建了一支强大的指导团队，以确保 候选人将获得宝贵的技术培训、研究经验和职业发展。 因此，本提议的补充将为候选人提供一个职业发展平台，同时 同时，如概述的那样，通过减少科学研究队伍中代表性不足的情况来促进多样性 在 FOA (PA-18-906) 中。从拟议的补充中获得的新见解将高度补充和 加强母基金中的项目。