Tuning multivalency for optimized ligand presentation

项目总结/摘要 这是一份促进健康相关研究多样性的研究补充申请， 补充我们的母基金，“优化配体呈现的多价性调整”（R35 GM 138296）。的 补充资金将支持塞萨尔拉米雷斯，谁在秋季2022年开始他的第二年作为博士学位。学生 我在罗格斯大学生物医学工程系的实验室。作为第一代西班牙裔 塞萨尔是来自萨尔瓦多的永久居民，他在学术界表现出令人难以置信的动力和热情，并取得了卓越的成就 科学在本母公司资助范围内，塞萨尔将开发定量构效关系 （QSAR）模型，这将使我们能够准确地塑造合成的多价配体， 可编程细胞信号的动力学。为了实现这一宏伟目标，我们创建了一个研究和 职业发展计划，将最大限度地发挥塞萨尔的潜力，是专门为他的项目， 个人需要。该计划将建立在塞萨尔以前的研究经验，并帮助他发展 这些复杂的生物物理相互作用的计算模型。同时，塞萨尔将继续他的 课程和博士候选人的要求，同时也申请奖学金和实习机会。通过 在这个为期两年的培训计划结束后，塞萨尔将成为工业界享有盛誉的工作的理想人选 或者学术界数据科学在生物医学技术发展中的应用正在增长 指数，和塞萨尔的独特经验/培训将是非常有价值的，在这个竞争激烈的就业市场。那里 毫无疑问，这将最大限度地发挥塞萨尔的潜力，帮助改变生物医学科学。

Project Summary/Abstract This is an application for a Research Supplement to Promote Diversity in Health-Related Research to complement our parent grant, “Tuning Multivalency for Optimized Ligand Presentation” (R35 GM138296). The supplement funds will support Cesar Ramirez, who in Fall 2022 is starting his second year as a Ph.D. student in my lab within the Department of Biomedical Engineering at Rutgers University. As a first-generation Hispanic permanent resident from El Salvador, Cesar has shown incredible drive and passion to excel in academia and science. Within the scope of this parent grant, Cesar will be developing quantitative structure-activity relationship (QSAR) models that will allow us to accurately shape synthetic multivalent ligands with optimized biophysical dynamics for programmable cell signaling. To achieve this ambitious goal, we have created a research and career development plan that will maximize Cesar’s potential that is specifically tailored to his project and personal needs. This plan will build on Cesar’s previous research experience and help him to develop computational models for these complex biophysical interactions. Meanwhile, Cesar will continue with his coursework and PhD candidacy requirements, while also applying for fellowship and internship opportunities. By the end of this two-year and beyond training plan, Cesar will be ideally positioned for prestigious jobs in industry or academia. The application of data-science towards the development of biomedical technologies is growing exponentially, and Cesar’s unique experience/training will be highly valuable in this competitive job market. There is no doubt that this will maximize Cesar’s potential to help transform the biomedical sciences.