Implementation Strategies to Promote Equitable Dissemination of Long-Acting injectable PrEP to Black/Latino MSM and Transgender Women in Los Angeles

项目摘要：艾滋病毒对与男性发生性关系的黑人和拉丁美洲男子的影响不成比例 和跨性别女性（BLMSM/TGW）。这些人口将大大受益于抢先体验 新的艾滋病预防工具。最近，食品和药物管理局批准了Apretude（一种 卡替拉韦的缓释注射剂形式）用作长效注射剂 预防措施（LAI PrEP），以降低通过性行为感染艾滋病毒的风险。公平传播 将LAI PrEP用于BLMSM/TGW可以帮助减少这些人群中的新艾滋病毒感染。 不幸的是，从历史上看，这些人口一直落后于更优越，资源丰富， 白色男同性恋者在接受有关最新的艾滋病毒预防方案和手段的信息， 让他们从早期采用中受益。因此，本项目的目标是在 探索、准备、实施和维持的“探索和准备”阶段 执行框架，以执行促进公平传播 洛杉矶县（LAC）BLMSM/TGW之间的LAI PrEP。该项目的重点是预防 这是国家终止艾滋病毒流行倡议的支柱，并与拉丁美洲和加勒比的EHE计划保持一致， PrEP扩大努力，减少获取和继续的障碍。该项目有三个具体 目标。目标1和2是提高对土地退化指数的认识和了解，以及对土地退化指数的信任和信心 PrEP作为BLMSM/TGW和为他们服务的提供者之间的新艾滋病毒预防选择。目标3是 制定LAI PrEP战略信息指南，以支持LAI PrEP信息的持续传播 由拉丁美洲和加勒比公共卫生部艾滋病毒和性传播疾病方案司和BLMSM/TGW服务处提供 提供者，以促进更大的社区意识和刺激社区的话语， 在拉丁美洲和加勒比的BLMSM/TGW中使用这一新的艾滋病毒预防工具。为了实现目标1和2，我们将 采用社区参与的方法，开发一系列信息/教育社区 研讨会（n = 7），优先考虑和先发制人地建立服务提供商和消费者的意识， 知识和信心，LAI PrEP作为BLMSM/TGW可接受的艾滋病毒预防选择， Lac.为了完成目标3，我们将与BLMSM/TGW进行焦点小组（n = 6）， 制定一个地方干预计划PrEP战略信息指南， 信息传送.该项目的预期成果是创造更大的社区意识，信任， 消费者对LAI PrEP作为BLMSM/TGW的艾滋病毒预防选择的信心， 服务商该项目的预期影响是更公平地传播信息， 在拉丁美洲和加勒比艾滋病毒负担沉重的高危BLMSM/TGW中实施LAI PrEP。

PROJECT ABSTRACT: HIV disproportionately affects Black and Latino men who have sex with men and transgender women (BLMSM/TGW). These populations would greatly benefit from early access to new HIV prevention tools. Recently, the Food and Drug Administration approved Apretude (an extended-release injectable form of cabotegravir) for use as long-acting injectable pre-exposure prophylaxis (LAI PrEP) to reduce the risk of acquiring HIV through sex. The equitable dissemination of LAI PrEP to BLMSM/TGW can help decrease new HIV infections in these populations. Unfortunately, historically these populations have lagged behind more privileged, well-resourced, White gay men in receiving information about the newest HIV prevention options and the means of accessing them to benefit from early adoption. As such, the goal of this project is to work within the “Exploration and Preparation” phases of the Exploration, Preparation, Implementation, Sustainment (EPIS) implementation framework to implement strategies to promote the equitable dissemination of LAI PrEP among BLMSM/TGW in Los Angeles County (LAC). This project focuses on the Prevent pillar of the national Ending the HIV Epidemic initiative and aligns with LAC’s EHE plan to facilitate PrEP scale up efforts and reduce barriers to access and continuation. The project has three specific aims. Aims 1 and 2 are to increase awareness and knowledge of, and trust and confidence in, LAI PrEP as a new HIV prevention option among BLMSM/TGW and providers serving them. Aim 3 is to develop a LAI PrEP strategic messaging guide to support ongoing diffusion of LAI PrEP information by the LAC Public Health Department’s Division of HIV and STD Programs and BLMSM/TGW service providers to facilitate greater community awareness and stimulate community discourse about the use of this new HIV prevention tool among BLMSM/TGW in LAC. To achieve aims 1 and 2, we will use a community-engaged approach to develop a series of informational/ educational community workshops (n = 7) that prioritize and preemptively build service provider and consumer awareness, knowledge, and confidence in LAI PrEP as an acceptable HIV prevention option for BLMSM/TGW in LAC. To complete aim 3, we will conduct focus groups (n = 6) with BLMSM/TGW to inform the development of a LAI PrEP strategic messaging guide of community-developed, culturally appropriate messaging. The expected outcome of the project is creating greater community awareness, trust, and confidence in LAI PrEP as a HIV prevention option for BLMSM/TGW among both consumers and service providers. The anticipated impact of the project is a more equitable dissemination and implementation of LAI PrEP among at-risk BLMSM/TGW heavily burdened by HIV in LAC.