Implementation Strategies to Promote Equitable Dissemination of Long-Acting injectable PrEP to Black/Latino MSM and Transgender Women in Los Angeles

项目摘要：艾滋病毒对与男性发生性行为的黑人和拉丁裔男性的影响不成比例 和变性人妇女(BLMSM/TGW)。这些人口将极大地受益于及早获得 到新的艾滋病毒预防工具。最近，美国食品和药物管理局批准了Apreude(An 卡波替格韦缓释注射剂型)，用作长效注射用预暴露 预防(Lai PrEP)，以降低通过性行为感染艾滋病毒的风险。公平分配 将LAI PrEP改为BLMSM/TGW有助于减少这些人群中新的艾滋病毒感染。 不幸的是，从历史上看，这些人口一直落后于更有特权、资源丰富、 白人男同性恋者获得有关最新艾滋病毒预防选择和手段的信息 访问它们以从早期采用中受益。因此，该项目的目标是在 探索、准备、实施、持续的“探索和准备”阶段 (EPIS)执行战略，以促进公平传播 洛杉矶县(LAC)BLMSM/TGW中的Lai PrEP。这个项目的重点是预防 国家终止艾滋病毒流行倡议的支柱，并与拉丁美洲和加勒比经济、社会和文化组织的计划保持一致，以促进 Prep加大努力，减少获取和继续的障碍。该项目有三个具体的 目标。目标一和目标二是增加对赖的认识和了解，以及对赖的信任和信心 在BLMSM/TGW和为他们提供服务的提供者中，PREP成为一种新的艾滋病毒预防选择。目标3是 制定LAI PrEP战略消息传送指南，以支持LAI PrEP信息的持续传播 由拉丁美洲和加勒比公共卫生部艾滋病毒和性传播疾病规划和BLMSM/TGW服务司提供 供应商，以促进更多的社区意识和刺激社区讨论 这一新的艾滋病毒预防工具在拉丁美洲和加勒比地区的青壮年和青壮年妇女中使用。为了实现目标1和目标2，我们将 使用社区参与的方法来开发一系列信息/教育社区 研讨会(n=7)，优先并先发制人地建立服务提供商和消费者的意识， 对Lai PrEP作为#年BLMSM/TGW可接受的HIV预防选择的知识和信心 乳胶。为了完成目标3，我们将与BLMSM/TGW进行焦点小组(n=6)，以告知 制定社区发展的、符合文化需要的LAI PrEP战略信息指南 消息传递。该项目的预期结果是创建更多的社区意识、信任和 消费者和妇女对Lai PrEP作为BLMSM/TGW艾滋病毒预防选择的信心 服务提供商。该项目的预期影响是更公平地传播和 在拉丁美洲和加勒比地区艾滋病毒负担沉重的高危BLMSM/TGW中实施LAI PrEP。

PROJECT ABSTRACT: HIV disproportionately affects Black and Latino men who have sex with men and transgender women (BLMSM/TGW). These populations would greatly benefit from early access to new HIV prevention tools. Recently, the Food and Drug Administration approved Apretude (an extended-release injectable form of cabotegravir) for use as long-acting injectable pre-exposure prophylaxis (LAI PrEP) to reduce the risk of acquiring HIV through sex. The equitable dissemination of LAI PrEP to BLMSM/TGW can help decrease new HIV infections in these populations. Unfortunately, historically these populations have lagged behind more privileged, well-resourced, White gay men in receiving information about the newest HIV prevention options and the means of accessing them to benefit from early adoption. As such, the goal of this project is to work within the “Exploration and Preparation” phases of the Exploration, Preparation, Implementation, Sustainment (EPIS) implementation framework to implement strategies to promote the equitable dissemination of LAI PrEP among BLMSM/TGW in Los Angeles County (LAC). This project focuses on the Prevent pillar of the national Ending the HIV Epidemic initiative and aligns with LAC’s EHE plan to facilitate PrEP scale up efforts and reduce barriers to access and continuation. The project has three specific aims. Aims 1 and 2 are to increase awareness and knowledge of, and trust and confidence in, LAI PrEP as a new HIV prevention option among BLMSM/TGW and providers serving them. Aim 3 is to develop a LAI PrEP strategic messaging guide to support ongoing diffusion of LAI PrEP information by the LAC Public Health Department’s Division of HIV and STD Programs and BLMSM/TGW service providers to facilitate greater community awareness and stimulate community discourse about the use of this new HIV prevention tool among BLMSM/TGW in LAC. To achieve aims 1 and 2, we will use a community-engaged approach to develop a series of informational/ educational community workshops (n = 7) that prioritize and preemptively build service provider and consumer awareness, knowledge, and confidence in LAI PrEP as an acceptable HIV prevention option for BLMSM/TGW in LAC. To complete aim 3, we will conduct focus groups (n = 6) with BLMSM/TGW to inform the development of a LAI PrEP strategic messaging guide of community-developed, culturally appropriate messaging. The expected outcome of the project is creating greater community awareness, trust, and confidence in LAI PrEP as a HIV prevention option for BLMSM/TGW among both consumers and service providers. The anticipated impact of the project is a more equitable dissemination and implementation of LAI PrEP among at-risk BLMSM/TGW heavily burdened by HIV in LAC.