Affordable, UV-, heat- and water-resistant radiochromic film composed of diacetylenes having chromophoric groups

由具有发色基团的丁二炔组成的经济实惠、抗紫外线、耐热和防水的放射变色薄膜

• 批准号: 10601369
• 负责人: Gordhanbhai Nathalal Patel
• 金额: --
• 依托单位: J P LABORATORIES, INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2023-04-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601369
• 关键词: Characteristics; Chemistry; Clinic; Clinical; Color; Cryopreservation; Development; Dose; Dose Rate; Dyes; Emulsions; Evaluation; Exposure to; Film; Film Dosimetry; Formulation; Glycols; Goals; Humidity; Ink; Investigation; Isocyanates; Knowledge; Laboratories; Life; Light; Measurement; Measures; Medical; Minnesota; Nature; Patients; Penetration; Performance; Polyesters; Polymers; Postdoctoral Fellow; Predisposition; Preparation; Principal Investigator; Radiation; Radiation Dose Unit; Radiation Protection; Radiation therapy; Reaction; Reading; Resistance; Resolution; Self Correction; Shipping; Techniques; Technology; Temperature; Testing; Thick; Treatment-related toxicity; Ultraviolet Rays; Universities; Urethane; Variant; Water; Work; absorption; clinical application; clinical implementation; cost; cost effective; dosimetry; experience; experimental study; improved; irradiation; manufacturing process; melting; novel; polymerization; prevent; prototype; response; safe patient; skills; solid state; tool; tumor growth; two-dimensional

Project Summary: Self-developing, instant radiochromic films based on the solid-state polymerization of diacetylenes (R-C≡C-C≡C- R’, where R and R’ are substituent groups) are used for measuring radiation therapy dose. Currently available radiochromic films, e.g., the GafChromicTM EBT films from Ashland (Bridgewater, NJ, USA), have many drawbacks such as they are very expensive, sensitive to water and ambient UV light, requiring cold storage and shipping, a short shelf-life, delamination of the coating if bent sharply or cut, non-uniform coating requiring a yellow dye for thickness correction, etc. These shortcomings have prevented their broader use in radiation therapy clinics. Hence, there is a strong need for more economical radiochromic films, which do not have the drawbacks of commercially available radiochromic films. One of the principal investigators, G.N. Patel, is one of the early pioneers in the field of diacetylenes and is still active in the field. His company, JP Laboratories, Inc., has developed radiation dosimeters and radiochromic films for radiation protection and other non-medical applications. Utilizing his extensive experience in diacetylene chemistry and synthesis, we will synthesize a class of diacetylenes, which have a chromophoric group as a substituent group, e.g., R = (CH2)n-OCONH-(CH2)n-A, where n=1-4, A is a light yellow color chromophoric group. The chromophoric diacetylenes (CD) will be produced by reacting diacetylene diols with chromophoric isocyanates. Then, CD-based emulsion, a coating formulation, will be prepared and uniformly coated on a polyester film substrate to create a CD film. Diacetylene diols are significantly less expensive than those used to make GafChromicTM films. The radiochromic films made from chromophoric diacetylenes, the CD film, will have none of the drawbacks of GafChromicTM films. The chromophoric group will absorb UV light. Hence the CD film will not develop color upon exposure to ambient UV light. The CD film will not require a yellow marker for the thickness correction because the CD is yellow. Diacetylenes with urethane (- OCONH-) functionality usually have a higher melting point (above 100°C), resulting in a longer shelf-life, and are not affected by water/humidity. Because of the high melting point of CD, the CD film can be briefly heated to eliminate the post-irradiation change of measured dose, allowing an instant reading of the radiation dose. In the first stage of the project, small quantities of chromophoric diacetylenes will be synthesized, inks/emulsions made of CD will be coated on a substrate to make the radiochromic films, and the prototype films will be evaluated. The best performing CD film will be selected, and a sufficient quantity of the film will be made for the extensive evaluation for radiation therapy applications. In the second stage, the chosen CD film will be assessed for the effect of dose, dose rate, energy, UV light, water/humidity, and heat (shelf-life). JP Labs and the University of Minnesota facilities are fully equipped to carry out the proposed work.

项目总结： 基于双乙炔固相聚合的自行显影的瞬时辐射变色薄膜(R-C≡C-C≡C-C- R‘，其中R和R’是取代基)用于测量放射治疗剂量。目前可用 辐射变色薄膜，例如来自阿什兰(美国新泽西州布里奇沃特)的GafChromiTM EBT薄膜，具有许多 缺点，如非常昂贵，对水和周围的紫外线很敏感，需要冷藏和 运输，保质期短，如果急剧弯曲或切割，涂层会分层，不均匀的涂层需要 用于厚度校正的黄色染料等。这些缺点阻碍了它们在辐射中的更广泛使用 治疗诊所。因此，对更经济的辐射变色薄膜有强烈的需求，这种薄膜没有 商业上可用的辐射变色薄膜的缺点。主要调查人员之一，G.N.Patel是 是二乙炔领域的早期先驱，至今仍活跃在该领域。他的公司，JP实验室，Inc. 已经开发了用于辐射防护和其他非医疗领域的辐射剂量计和辐射变色薄膜 申请。利用他在二乙炔化学和合成方面的丰富经验，我们将合成一个 对于具有发色基团作为取代基的二乙苯，例如R=(CH2)n-OCONH-(CH2)n-A， 其中n=1-4，A为淡黄色发色基团。将产生发色的二乙炔(CD) 通过二乙炔二醇与发色异氰酸酯反应。然后，CD基乳剂、涂料配方、 将其制备并均匀涂覆在聚酯膜基材上，形成CD膜。二乙炔二醇是 比用于制作GafChromiTM薄膜的成本低得多。由以下物质制成的辐射变色薄膜 发色的二乙炔，CD膜，将不会有GafChromiTM膜的缺点。这个 发色基团会吸收紫外线。因此，CD胶片在暴露在环境紫外线下时不会显色 灯。CD膜不需要黄色标记来进行厚度校正，因为CD是黄色的。 具有氨基甲酸酯(-OCONH-)官能团的二乙炔通常具有较高的熔点(100°C以上)，结果 保质期更长，不受水分/湿度的影响。由于Cd的高熔点，Cd 胶片可短暂加热，以消除照射后测量剂量的变化，从而实现即时读取 辐射剂量。在该项目的第一阶段，将有少量的发色剂二乙炔 合成后，将由CD制成的油墨/乳剂涂覆在衬底上，以制备辐射变色薄膜，并且 将对原型电影进行评估。将选出表现最好的CD电影，并提供足够数量的 将为放射治疗应用的广泛评估制作胶片。在第二阶段，被选中的 将评估CD膜的剂量、剂量率、能量、紫外线、水/湿度和热(保质期)的影响。 摩根大通实验室和明尼苏达大学的设施已经完全准备好进行拟议的工作。