Affordable, UV-, heat- and water-resistant radiochromic film composed of diacetylenes having chromophoric groups

由具有发色基团的丁二炔组成的经济实惠、抗紫外线、耐热和防水的放射变色薄膜

• 批准号: 10601369
• 负责人: Gordhanbhai Nathalal Patel
• 金额: --
• 依托单位: J P LABORATORIES, INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2023-04-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601369
• 关键词: Characteristics; Chemistry; Clinic; Clinical; Color; Cryopreservation; Development; Dose; Dose Rate; Dyes; Emulsions; Evaluation; Exposure to; Film; Film Dosimetry; Formulation; Glycols; Goals; Humidity; Ink; Investigation; Isocyanates; Knowledge; Laboratories; Life; Light; Measurement; Measures; Medical; Minnesota; Nature; Patients; Penetration; Performance; Polyesters; Polymers; Postdoctoral Fellow; Predisposition; Preparation; Principal Investigator; Radiation; Radiation Dose Unit; Radiation Protection; Radiation therapy; Reaction; Reading; Resistance; Resolution; Self Correction; Shipping; Techniques; Technology; Temperature; Testing; Thick; Treatment-related toxicity; Ultraviolet Rays; Universities; Urethane; Variant; Water; Work; absorption; clinical application; clinical implementation; cost; cost effective; dosimetry; experience; experimental study; improved; irradiation; manufacturing process; melting; novel; polymerization; prevent; prototype; response; safe patient; skills; solid state; tool; tumor growth; two-dimensional

Project Summary: Self-developing, instant radiochromic films based on the solid-state polymerization of diacetylenes (R-C≡C-C≡C- R’, where R and R’ are substituent groups) are used for measuring radiation therapy dose. Currently available radiochromic films, e.g., the GafChromicTM EBT films from Ashland (Bridgewater, NJ, USA), have many drawbacks such as they are very expensive, sensitive to water and ambient UV light, requiring cold storage and shipping, a short shelf-life, delamination of the coating if bent sharply or cut, non-uniform coating requiring a yellow dye for thickness correction, etc. These shortcomings have prevented their broader use in radiation therapy clinics. Hence, there is a strong need for more economical radiochromic films, which do not have the drawbacks of commercially available radiochromic films. One of the principal investigators, G.N. Patel, is one of the early pioneers in the field of diacetylenes and is still active in the field. His company, JP Laboratories, Inc., has developed radiation dosimeters and radiochromic films for radiation protection and other non-medical applications. Utilizing his extensive experience in diacetylene chemistry and synthesis, we will synthesize a class of diacetylenes, which have a chromophoric group as a substituent group, e.g., R = (CH2)n-OCONH-(CH2)n-A, where n=1-4, A is a light yellow color chromophoric group. The chromophoric diacetylenes (CD) will be produced by reacting diacetylene diols with chromophoric isocyanates. Then, CD-based emulsion, a coating formulation, will be prepared and uniformly coated on a polyester film substrate to create a CD film. Diacetylene diols are significantly less expensive than those used to make GafChromicTM films. The radiochromic films made from chromophoric diacetylenes, the CD film, will have none of the drawbacks of GafChromicTM films. The chromophoric group will absorb UV light. Hence the CD film will not develop color upon exposure to ambient UV light. The CD film will not require a yellow marker for the thickness correction because the CD is yellow. Diacetylenes with urethane (- OCONH-) functionality usually have a higher melting point (above 100°C), resulting in a longer shelf-life, and are not affected by water/humidity. Because of the high melting point of CD, the CD film can be briefly heated to eliminate the post-irradiation change of measured dose, allowing an instant reading of the radiation dose. In the first stage of the project, small quantities of chromophoric diacetylenes will be synthesized, inks/emulsions made of CD will be coated on a substrate to make the radiochromic films, and the prototype films will be evaluated. The best performing CD film will be selected, and a sufficient quantity of the film will be made for the extensive evaluation for radiation therapy applications. In the second stage, the chosen CD film will be assessed for the effect of dose, dose rate, energy, UV light, water/humidity, and heat (shelf-life). JP Labs and the University of Minnesota facilities are fully equipped to carry out the proposed work.

项目概要： 基于二乙炔（R-C-C-C-C- R ′，其中R和R ′是取代基）用于测量放射治疗剂量。当前可用 辐射变色膜，例如，来自阿什兰（Bridgewater，NJ，USA）的GafChromicTM EBT膜具有许多 缺点是它们非常昂贵，对水和环境紫外光敏感，需要冷藏， 运输，保质期短，如果急剧弯曲或切割，涂层分层，不均匀的涂层需要 用于厚度校正的黄色染料等。这些缺点阻碍了它们在辐射中的广泛应用 治疗诊所因此，强烈需要更经济的辐射变色膜，其不具有辐射变色性。 市售辐射变色胶片的缺点。主要研究人员之一，G. N。帕特尔是 是二乙炔领域的早期先驱，至今仍活跃在该领域。他的公司JP实验室公司， 开发了辐射剂量计和辐射变色胶片，用于辐射防护和其他非医疗 应用.利用他在二乙炔化学和合成方面的丰富经验，我们将合成一类 具有发色基团作为取代基的二乙炔，例如，R =（CH 2）n-OCONH-（CH 2）n-A， 其中n=1-4，A为浅黄色发色基团。发色团二乙炔（CD）将产生 通过使二乙炔二醇与发色异氰酸酯反应。然后，将基于CD的乳液、涂料制剂 将被制备并均匀地涂覆在聚酯膜基底上以产生CD膜。二乙炔二醇是 比用于制造GafChromicTM薄膜的成本低得多。由以下材料制成的辐射变色胶片 发色团二乙炔，CD膜，将没有GafChromicTM膜的缺点。的 发色团会吸收紫外线。因此，CD胶片在暴露于环境紫外线时不会显色 光由于CD是黄色的，因此CD胶片不需要黄色标记进行厚度校正。 具有氨基甲酸酯（- OCONH-）官能度的二乙炔通常具有较高的熔点（高于100°C），从而导致 保质期更长，不受水/湿度的影响。由于CD的高熔点， 胶片可短暂加热，以消除辐照后测量剂量的变化，从而实现即时阅读 辐射剂量。在该项目的第一阶段，少量的发色团二乙炔将被 合成的，由CD制成的油墨/乳剂将被涂覆在基底上以制造辐射变色膜，并且 将对原型电影进行评估。将选择表现最好的CD胶片，并提供足够数量的 电影将被广泛评价放射治疗的应用。在第二阶段，被选中的人 将评估CD薄膜的剂量、剂量率、能量、UV光、水/湿度和热（有效期）的影响。 JP实验室和明尼苏达大学的设施配备齐全，可以开展拟议的工作。