Reducing the Risk and Economic burden of Recurrent stroke by improving medication adherence using a Novel SMART Pill CONTAINER, Cap, and Health Literacy Technologies

使用新型智能药丸容器、瓶盖和健康素养技术提高用药依从性，降低复发性中风的风险和经济负担

• 批准号: 10601743
• 负责人: Edwin Kendrick
• 金额: $ 29.85万
• 依托单位: SANO HEALTHCARE CONSULTANTS, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601743
• 关键词: Acceleration; Adherence; Algorithms; Alloys; Archives; Area; Bar Codes; Black Populations; Black race; Calibration; Cardiovascular system; Cause of Death; Cells; Charge; Chronic; Classification; Data Scientist; Data Storage and Retrieval; Deglutition; Development; Device Designs; Devices; Disabled Persons; Disparity; Dose; Economic Burden; Engineering; Environmental Monitoring; Family; Food; Frequencies; Future; Grant; Hand; Hand functions; Health; Home; Human; Humidity; Incidence; Intervention; Ischemic Stroke; Laboratories; Language; Left; Liquid substance; Manuals; Measures; Medicine; Metals; Monitor; Morbidity - disease rate; Noise; Outcome; Periodicity; Persons; Pharmaceutical Preparations; Pharmacy Schools; Pharmacy facility; Phase; Populations at Risk; Prevention; Recurrence; Relative Risks; Research; Resolution; Risk Reduction; Rotation; Scanning; Silicones; Software Tools; Stroke; System; Target Populations; Taxonomy; Technology; Testing; Time; Universities; Upper Extremity; Water; Weight; commercialization; cost; cost effective; design; dexterity; disability; evidence based guidelines; experience; graphene; grasp; health disparity; health literacy; improved; innovation; medication compliance; medication safety; metrology; middle age; mortality; nanosheet; novel; pill; prevent; prototype; sensor; social health determinants; stroke risk; stroke survivor; touchscreen

Stroke is the leading cause of death and disability worldwide with the strongest disparity in strokes seen in Black middle-aged persons. Black persons have incidence rates of ischemic stroke that are 2- to 3-fold higher than Whites. Additionally, over 80% of stroke survivors will have immediate and persistent weakness of their upper limb, leaving half of the persons with a chronic disability and inability to complete simple and basic manual dexterity activities, including taking medications as prescribed (Medication adherence). The greatest areas where stroke survivors need help all of the time was in taking medicines out of a box, packet or bottle, with remaining support needed in managing prescriptions, receiving alerts of medication dosing times, swallowing medicines, and (d) remembering if a medication was taken. Current competitors have significant design barriers that limit access to disabled persons, medication safety, and Social Determinants of Health (SDOH). Accurate adherence monitoring requires determining whether morbidity and mortality are a result of full or partial compliance or persistent use of medication. Multiple sensors should be attached to the pill bottle to detect and monitor medication adherence to improve accuracy of detecting partial compliance, persistent use, and determining correlates of stroke-risk reduction outcomes. SANO’s novel Pharmacy Environmental Interactive Device (EID) prototype is designed to eliminate health disparities by preventing cardiovascular complications in stroke survivors by overcoming many of these barriers to medication adherence. SANO’s novel and patentable EID is designed for (a) singlehand use in stroke survivors (disability solution); (b) dual in-home dosing alert and adherence monitoring system by measuring pill weight and SMART Container manipulation (medication safety/adherence); (c) use of a cardiovascular taxonomy classification system designed for culturally sensitive and preferred health literacy language (health literacy); (d) a reusable SMART container and cap for use with low-cost cardiovascular medications (social determinants of health). SANO’s additional engineering innovation will also test two types of strain gauge sensors (metal alloy and graphene nanosheets synthesized using a water- assisted liquid phase exfoliation), thereby expanding the commercial load cell family of materials to include strain gauges as a value-based in-home prescription scale. Future health innovations and interventions must target the population at risk, the number of persons truly at risk relative to the size of the target group, be cost-effective in prevention and treatment, and be culturally sensitive to improve intervention use in the targeted population.

中风是全球死亡和残疾的主要原因， 在中年黑人中看到的中风。黑人的缺血性心脏病发病率 中风比白人高2到3倍。此外，超过80%的中风幸存者将 有立即和持久的弱点，他们的上肢，留下一半的人有一个 慢性残疾和无法完成简单和基本的手工灵巧活动， 包括按处方服药（服药依从性）。最大的领域， 中风幸存者需要帮助的所有时间是从盒子，包或瓶子里拿药， 在管理处方、接收药物剂量警报方面需要其他支持 时间，吞咽药物，以及（d）记住是否服用药物。电流 竞争对手有重大的设计障碍，限制残疾人，药物 健康的社会决定因素（Social Determinants of Health，SDOH）准确的依从性监控需要 确定发病率和死亡率是完全依从还是部分依从的结果， 持续使用药物。应将多个传感器连接到药瓶上以检测和 监测药物依从性，以提高检测部分依从性的准确性，持续 使用，并确定中风风险降低结果的相关性。佐野小说《药剂学》 环境交互设备（EID）原型旨在消除健康差距， 预防中风幸存者的心血管并发症， 药物依从性的障碍。佐野的新颖和专利EID是专为（一）单一中风幸存者的手部使用（残疾解决方案）;（B）双重家庭给药警报和依从性 通过测量药丸重量和SMART容器操作（药物） 安全性/依从性）;（c）使用设计用于 具有文化敏感性和首选的卫生知识普及语言（卫生知识普及）;（d）可重复使用的 用于低成本心血管药物的SMART容器和盖（社会 健康的决定因素）。佐野的额外工程创新还将测试两种类型的 应变计传感器（金属合金和石墨烯纳米片， 液相剥落），从而扩展了商用称重传感器材料族， 包括应变仪作为基于值家庭处方量表。未来的健康创新 干预措施必须针对处于风险中的人群，真正处于风险中的人数相对于 目标群体的规模，在预防和治疗方面具有成本效益， 敏感，以改善干预措施在目标人群中的使用。