Reducing the Risk and Economic burden of Recurrent stroke by improving medication adherence using a Novel SMART Pill CONTAINER, Cap, and Health Literacy Technologies

使用新型智能药丸容器、瓶盖和健康素养技术提高用药依从性，降低复发性中风的风险和经济负担

• 批准号: 10601743
• 负责人: Edwin Kendrick
• 金额: $ 29.85万
• 依托单位: SANO HEALTHCARE CONSULTANTS, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601743
• 关键词: Acceleration; Adherence; Algorithms; Alloys; Archives; Area; Bar Codes; Black Populations; Black race; Calibration; Cardiovascular system; Cause of Death; Cells; Charge; Chronic; Classification; Data Scientist; Data Storage and Retrieval; Deglutition; Development; Device Designs; Devices; Disabled Persons; Disparity; Dose; Economic Burden; Engineering; Environmental Monitoring; Family; Food; Frequencies; Future; Grant; Hand; Hand functions; Health; Home; Human; Humidity; Incidence; Intervention; Ischemic Stroke; Laboratories; Language; Left; Liquid substance; Manuals; Measures; Medicine; Metals; Monitor; Morbidity - disease rate; Noise; Outcome; Periodicity; Persons; Pharmaceutical Preparations; Pharmacy Schools; Pharmacy facility; Phase; Populations at Risk; Prevention; Recurrence; Relative Risks; Research; Resolution; Risk Reduction; Rotation; Scanning; Silicones; Software Tools; Stroke; System; Target Populations; Taxonomy; Technology; Testing; Time; Universities; Upper Extremity; Water; Weight; commercialization; cost; cost effective; design; dexterity; disability; evidence based guidelines; experience; graphene; grasp; health disparity; health literacy; improved; innovation; medication compliance; medication safety; metrology; middle age; mortality; nanosheet; novel; pill; prevent; prototype; sensor; social health determinants; stroke risk; stroke survivor; touchscreen

Stroke is the leading cause of death and disability worldwide with the strongest disparity in strokes seen in Black middle-aged persons. Black persons have incidence rates of ischemic stroke that are 2- to 3-fold higher than Whites. Additionally, over 80% of stroke survivors will have immediate and persistent weakness of their upper limb, leaving half of the persons with a chronic disability and inability to complete simple and basic manual dexterity activities, including taking medications as prescribed (Medication adherence). The greatest areas where stroke survivors need help all of the time was in taking medicines out of a box, packet or bottle, with remaining support needed in managing prescriptions, receiving alerts of medication dosing times, swallowing medicines, and (d) remembering if a medication was taken. Current competitors have significant design barriers that limit access to disabled persons, medication safety, and Social Determinants of Health (SDOH). Accurate adherence monitoring requires determining whether morbidity and mortality are a result of full or partial compliance or persistent use of medication. Multiple sensors should be attached to the pill bottle to detect and monitor medication adherence to improve accuracy of detecting partial compliance, persistent use, and determining correlates of stroke-risk reduction outcomes. SANO’s novel Pharmacy Environmental Interactive Device (EID) prototype is designed to eliminate health disparities by preventing cardiovascular complications in stroke survivors by overcoming many of these barriers to medication adherence. SANO’s novel and patentable EID is designed for (a) singlehand use in stroke survivors (disability solution); (b) dual in-home dosing alert and adherence monitoring system by measuring pill weight and SMART Container manipulation (medication safety/adherence); (c) use of a cardiovascular taxonomy classification system designed for culturally sensitive and preferred health literacy language (health literacy); (d) a reusable SMART container and cap for use with low-cost cardiovascular medications (social determinants of health). SANO’s additional engineering innovation will also test two types of strain gauge sensors (metal alloy and graphene nanosheets synthesized using a water- assisted liquid phase exfoliation), thereby expanding the commercial load cell family of materials to include strain gauges as a value-based in-home prescription scale. Future health innovations and interventions must target the population at risk, the number of persons truly at risk relative to the size of the target group, be cost-effective in prevention and treatment, and be culturally sensitive to improve intervention use in the targeted population.

中风是全球死亡和残疾的主要原因，具有强烈的差距 在黑人中年人中看到的中风。黑人有缺血性的发病率 中风比白人高2至3倍。此外，超过80％的中风表面将 上肢有直接和持续的弱点，使一半的人有一个 慢性残疾和无法完成简单和基本的手动敏捷活动， 包括服用处方药（药物依从性）。最伟大的地区 中风冲浪者最需要帮助，就是将药物从盒子，包装或瓶子中取出 在管理处方所需的剩余支持下，接收药物剂量的警报 时间，吞咽药物，（d）记住是否服用药物。当前的 竞争对手具有重大的设计障碍，可以限制对残疾人的机会，药物治疗 安全和卫生的社会决定因素（SDOH）。准确的依从性监测需要 确定发病率和死亡率是全部或部分合规性的结果还是 持续使用药物。应将多个传感器连接到药瓶上以检测和 监测药物依从性以提高检测部分合规性的准确性 使用并确定中风风险减少结果的相关性。萨诺的小说药 环境交互设备（EID）原型旨在消除健康分布 通过克服其中的许多 药物依从性的障碍。 Sano的小说和可申请的EID设计用于（a）中风冲浪者的单手用（残疾解决方案）； （b）双重家庭剂量警报和依从性 通过测量药丸重量和智能容器操纵（药物）来监测系统 安全/依从性）； （c）使用旨在的心血管分类分类系统 对文化敏感和首选的健康素养语言（健康素养）； （d）可重复使用的 与低成本心血管药物一起使用的智能容器和帽子（社交 确定健康）。 Sano的其他工程创新也将测试两种类型 应变量规传感器（金属合金和石墨烯纳米片使用水辅助 液相去角质），从而将商业负载电池的材料家族扩展到 将应变计作为基于价值的家庭处方量表。未来的健康创新 干预措施必须针对有风险的人群，实际上处于风险相关的人数 对于目标组的大小，在预防和治疗方面具有成本效益，并在文化上保持 对改善目标人群中的干预使用敏感。