2023 Cilia, Mucus and Mucociliary Interactions GRC & GRS

2023 纤毛、粘液和粘液纤毛相互作用 GRC

• 批准号: 10601200
• 负责人: BRIAN M BUTTON
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601200
• 关键词: Address; Adult; Area; Asthma; Automobile Driving; Biochemical; Biochemistry; Biological; Biological Models; Biology; Biomedical Engineering; Biophysics; COVID-19 pandemic; Cellular biology; Child; Chronic Bronchitis; Chronic Disease; Chronic Obstructive Pulmonary Disease; Cilia; Clinical; Collaborations; Cystic Fibrosis; Data; Development; Developmental Biology; Diagnosis; Diagnostic; Discipline; Disease; Education; Elements; Emerging Technologies; Environment; Epithelial Cells; Etiology; Faculty; Female; Fostering; Foundations; Functional disorder; Genetic; Genetic Diseases; Genetic Research; Genomics; Glycoproteins; Goals; Growth; Hair; Image; Infection; Inhalation; Italy; Knowledge; Leadership; Link; Lung diseases; Mechanics; Medicine; Mentors; Mentorship; Methods; Minority; Mission; Molecular; Mucins; Mucociliary Clearance; Mucous body substance; Oral; Participant; Pathologic; Physiology; Polymers; Postdoctoral Fellow; Primary Ciliary Dyskinesias; Production; Regulator Genes; Research; Research Personnel; Respiratory System; Respiratory Tract Diseases; Scientist; Senior Scientist; Structure; Surface; Talents; Technology; Translational Research; Underrepresented Minority; United States National Institutes of Health; Veins; Woman; Work; airway epithelium; burden of illness; career; cilium motility; empowerment; human disease; idiopathic pulmonary fibrosis; innovation; knowledge integration; lectures; meetings; minority scientist; molecular scale; multidisciplinary; multiple omics; nanoscale; novel; pathogen; posters; programs; public health relevance; research and development; respiratory health; stem; success; symposium; translational scientist

PROJECT SUMMARY This application seeks support for a Gordon Research Conference (GRC) and corresponding Gordon Research Seminar (GRS) on Cilia, Mucus and Mucociliary Interactions from February 18-24, 2023 in Barga, Italy. This is a highly integrated and unique meeting that unites basic scientists, bioengineers, translational investigators, and clinicians who study the components and fundamentals of cilia and mucus biology, their interface as a mucociliary apparatus, and human diseases related mucociliary dysfunction. Mucociliary clearance (MCC) is essential for respiratory tract defense against inhaled pathogens. MCC dysfunction leads to infections and to complications in asthma, rhinosinusitus, chronic obstructive lung disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). Advancing technologies have led to growing knowledge of the assembly and function of cilia, the production and secretion of mucin glycoproteins, and the cilia-mucus interactions required for MCC. These innovations stem from the on-going work of established teams and new entrants, including young investigators. Thus, an important element of this meeting is promoting trainees and young investigators and involving women and minorities in alignment with missions of the GRC and the NIH. This GRS/GRC meeting will lay foundations and provide new ideas for current and emerging leaders in the mucociliary biology. A cohesive program is proposed to enhance the interplay between specialized disciplines that seek to integrate knowledge and impact advances in biochemistry, biophysics, cell biology, development, genetics, and translational research of common respiratory tract diseases. To enhance the educational strength of the meeting, trainees will be invited to participate in a GRS, to present oral summaries of their posters during morning lecture blocks, and in some cases give 10 min talks during the GRC meeting. The GRS and GRC leadership teams have the shared goal of fostering an innovative, informative, and integrated forum for discussing novel research and current challenges in mucociliary biology. The conference will emphasize the following scientific themes: a) genetic and gene regulatory mechanisms of mucociliary components, b) structure and function of mucin glycoprotein polymers and motile cilia, c) secretion of mucins and mechanics of ciliary activity, d) the effects of mucociliary function and dysfunction on host physiology and pathophysiology, and e) the on-going application of cilia and mucus biology to develop promote respiratory health and reduce the burden of disease. With this approach, we seek to achieve three Specific Aims: 1) To disseminate, discuss, and integrate the latest, unpublished, cutting-edge data on cilia, mucus and mucociliary interactions in a forum of world experts and early career scientists; 2) to provide a platform that links fundamental scientific knowledge related to cilia, mucus, and mucociliary interactions to human disease and avenues for diagnosis and therapies; and 3) to facilitate and promote the involvement and advancement of underrepresented minorities, women, and trainees in the study of cilia, mucus and mucociliary interactions.

项目摘要 此应用程序寻求支持戈登研究会议（GRC）和相应的戈登研究 研讨会（GRS）纤毛，粘液和粘膜纤毛相互作用从2023年2月18日至24日在巴尔加，意大利。这是 一个高度集成和独特的会议，团结基础科学家，生物工程师，翻译研究人员， 研究纤毛和粘液生物学的组成和基础的临床医生，他们的界面作为一个 粘液纤毛器和人类疾病相关的粘液纤毛功能障碍。粘膜纤毛清除率（MCC）是 对呼吸道防御吸入的病原体至关重要。MCC功能障碍导致感染， 哮喘并发症、鼻窦炎、慢性阻塞性肺疾病（COPD）、特发性肺纤维化 (IPF)、囊性纤维化（CF）和原发性纤毛运动障碍（PCD）。先进的技术导致了 纤毛的组装和功能，粘蛋白糖蛋白的产生和分泌，以及 纤毛-粘液相互作用所需的MCC。这些创新源于现有团队的持续工作 和新加入者，包括年轻的研究人员。因此，本次会议的一个重要内容是促进 培训学员和年轻调查员，并根据克罗地亚共和国的任务，让妇女和少数民族参与进来， 国家卫生研究院本次GRS/GRC会议将为当前和新兴领导者奠定基础并提供新的想法 在黏膜纤毛生物学中。一个有凝聚力的计划提出，以加强专业之间的相互作用， 寻求整合知识和影响生物化学，生物物理学，细胞生物学， 常见呼吸道疾病的发展、遗传学和转化研究。增强 会议的教育力量，学员将被邀请参加一个GRS，提出口头总结 他们的海报在上午的讲座块，并在某些情况下，给10分钟的演讲在GRC会议。 GRS和GRC领导团队的共同目标是培养一个创新的，信息丰富的， 论坛讨论新的研究和当前的挑战，在粘液纤毛生物学。会议将 强调以下科学主题：a）粘膜纤毛的遗传和基因调节机制 组分，B）粘蛋白糖蛋白聚合物和运动纤毛的结构和功能，c）粘蛋白的分泌 和纤毛活动的机制，d）粘膜纤毛功能和功能障碍对宿主生理学的影响， 病理生理学，以及e）纤毛和粘液生物学的持续应用，以发展促进呼吸系统健康 并减轻疾病负担。通过这种方法，我们寻求实现三个具体目标：1） 传播、讨论和整合有关纤毛、粘液和粘液纤毛的最新、未发表的前沿数据 在世界专家和早期职业科学家论坛上进行互动; 2）提供一个平台， 与纤毛、粘液和粘液纤毛与人类疾病的相互作用有关的科学知识以及 诊断和治疗; 3）促进和促进代表性不足的人的参与和进步 少数民族，妇女和学员在纤毛，粘液和粘液纤毛的相互作用的研究。