2023 Cilia, Mucus and Mucociliary Interactions GRC & GRS

2023 纤毛、粘液和粘液纤毛相互作用 GRC

• 批准号: 10601200
• 负责人: BRIAN M BUTTON
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601200
• 关键词: Address; Adult; Area; Asthma; Automobile Driving; Biochemical; Biochemistry; Biological; Biological Models; Biology; Biomedical Engineering; Biophysics; COVID-19 pandemic; Cellular biology; Child; Chronic Bronchitis; Chronic Disease; Chronic Obstructive Pulmonary Disease; Cilia; Clinical; Collaborations; Cystic Fibrosis; Data; Development; Developmental Biology; Diagnosis; Diagnostic; Discipline; Disease; Education; Elements; Emerging Technologies; Environment; Epithelial Cells; Etiology; Faculty; Female; Fostering; Foundations; Functional disorder; Genetic; Genetic Diseases; Genetic Research; Genomics; Glycoproteins; Goals; Growth; Hair; Image; Infection; Inhalation; Italy; Knowledge; Leadership; Link; Lung diseases; Mechanics; Medicine; Mentors; Mentorship; Methods; Minority; Mission; Molecular; Mucins; Mucociliary Clearance; Mucous body substance; Oral; Participant; Pathologic; Physiology; Polymers; Postdoctoral Fellow; Primary Ciliary Dyskinesias; Production; Regulator Genes; Research; Research Personnel; Respiratory System; Respiratory Tract Diseases; Scientist; Senior Scientist; Structure; Surface; Talents; Technology; Translational Research; Underrepresented Minority; United States National Institutes of Health; Veins; Woman; Work; airway epithelium; burden of illness; career; cilium motility; empowerment; human disease; idiopathic pulmonary fibrosis; innovation; knowledge integration; lectures; meetings; minority scientist; molecular scale; multidisciplinary; multiple omics; nanoscale; novel; pathogen; posters; programs; public health relevance; research and development; respiratory health; stem; success; symposium; translational scientist

PROJECT SUMMARY This application seeks support for a Gordon Research Conference (GRC) and corresponding Gordon Research Seminar (GRS) on Cilia, Mucus and Mucociliary Interactions from February 18-24, 2023 in Barga, Italy. This is a highly integrated and unique meeting that unites basic scientists, bioengineers, translational investigators, and clinicians who study the components and fundamentals of cilia and mucus biology, their interface as a mucociliary apparatus, and human diseases related mucociliary dysfunction. Mucociliary clearance (MCC) is essential for respiratory tract defense against inhaled pathogens. MCC dysfunction leads to infections and to complications in asthma, rhinosinusitus, chronic obstructive lung disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). Advancing technologies have led to growing knowledge of the assembly and function of cilia, the production and secretion of mucin glycoproteins, and the cilia-mucus interactions required for MCC. These innovations stem from the on-going work of established teams and new entrants, including young investigators. Thus, an important element of this meeting is promoting trainees and young investigators and involving women and minorities in alignment with missions of the GRC and the NIH. This GRS/GRC meeting will lay foundations and provide new ideas for current and emerging leaders in the mucociliary biology. A cohesive program is proposed to enhance the interplay between specialized disciplines that seek to integrate knowledge and impact advances in biochemistry, biophysics, cell biology, development, genetics, and translational research of common respiratory tract diseases. To enhance the educational strength of the meeting, trainees will be invited to participate in a GRS, to present oral summaries of their posters during morning lecture blocks, and in some cases give 10 min talks during the GRC meeting. The GRS and GRC leadership teams have the shared goal of fostering an innovative, informative, and integrated forum for discussing novel research and current challenges in mucociliary biology. The conference will emphasize the following scientific themes: a) genetic and gene regulatory mechanisms of mucociliary components, b) structure and function of mucin glycoprotein polymers and motile cilia, c) secretion of mucins and mechanics of ciliary activity, d) the effects of mucociliary function and dysfunction on host physiology and pathophysiology, and e) the on-going application of cilia and mucus biology to develop promote respiratory health and reduce the burden of disease. With this approach, we seek to achieve three Specific Aims: 1) To disseminate, discuss, and integrate the latest, unpublished, cutting-edge data on cilia, mucus and mucociliary interactions in a forum of world experts and early career scientists; 2) to provide a platform that links fundamental scientific knowledge related to cilia, mucus, and mucociliary interactions to human disease and avenues for diagnosis and therapies; and 3) to facilitate and promote the involvement and advancement of underrepresented minorities, women, and trainees in the study of cilia, mucus and mucociliary interactions.

项目总结 此应用程序寻求支持戈登研究会议(GRC)和相应的戈登研究 2023年2月18日至24日在意大利巴尔加举行的纤毛、粘液和粘液纤毛相互作用研讨会(GRS)。这是 一次高度整合和独特的会议，将基础科学家、生物工程师、转化研究人员和 研究纤毛和粘液生物学的组成和基础的临床医生，他们的界面是一种 粘液纤毛器，与人类疾病相关的粘液纤毛功能障碍。粘液纤毛清除(MCC)是 对于呼吸道防御吸入病原体是必不可少的。MCC功能障碍会导致感染和 哮喘、鼻窦、慢性阻塞性肺疾病(COPD)、特发性肺纤维化的并发症 (IPF)、囊性纤维化(CF)和原发性睫状体运动障碍(PCD)。先进的技术导致了日益增长的 纤毛的组装和功能，粘蛋白糖蛋白的产生和分泌，以及 纤毛-粘液相互作用是MCC所必需的。这些创新源于老牌团队正在进行的工作 以及新进入者，包括年轻的调查人员。因此，本次会议的一个重要内容是促进 受训人员和青年调查人员，并使妇女和少数群体参与GRC和 美国国立卫生研究院。本次GRS/GRC会议将为现任和新兴领导人奠定基础并提供新想法 在粘液纤毛生物学中。提出了一个连贯的计划，以增强专业人员之间的互动 寻求整合知识并影响生物化学、生物物理学、细胞生物学、 常见呼吸道疾病的发展、遗传学和翻译研究。为了增强 在教育实力会议上，学员将被邀请参加GRS，进行口头总结 在上午的讲座中张贴他们的海报，在某些情况下在GRC会议期间进行10分钟的演讲。 GRS和GRC领导团队有一个共同的目标，那就是培养创新、信息丰富和集成的 讨论粘液纤毛生物学新研究和当前挑战的论坛。会议将于 强调以下科学主题：a)粘液纤毛的遗传和基因调节机制 组成，b)粘蛋白糖蛋白聚合物和活动纤毛的结构和功能，c)粘蛋白的分泌 和纤毛活动的机制，d)粘膜纤毛功能和功能障碍对宿主生理和 病理生理学，以及e)纤毛和粘液生物学的持续应用，以发展促进呼吸健康 减轻疾病负担。通过这种方法，我们寻求实现三个具体目标：1) 传播、讨论和整合有关纤毛、粘液和粘液纤毛的最新、未发表的尖端数据 在世界专家和早期职业科学家的论坛上进行互动；2)提供一个连接基础知识的平台 与纤毛、粘液和粘液纤毛相互作用与人类疾病有关的科学知识和途径 诊断和治疗；以及3)促进和促进任职人数不足的人的参与和进步 纤毛、粘液和粘液纤毛相互作用研究的少数民族、妇女和受训人员。