Core B - Statistical and Data Management

核心 B - 统计和数据管理

• 批准号: 10602484
• 负责人: Michael Malek-Ahmadi
• 金额: $ 25.66万
• 依托单位: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10602484
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Bioinformatics; Cellular Neurobiology; Chicago; Clinical; Cognitive; Data; Data Analyses; Data Set; Databases; Diagnosis; Disease Progression; Elderly; Eligibility Determination; Ensure; Exclusion Criteria; Goals; Laboratories; Libraries; Link; Mission; Molecular; Molecular Neurobiology; Network-based; Neurobiology; Pathologic; Program Research Project Grants; Research; Research Design; Research Personnel; Research Project Grants; Resources; Specific qualifier value; Statistical Data Interpretation; Tissue Sample; Tissues; basal forebrain; case-based; cholinergic; data integration; data library; data management; experience; human tissue; mild cognitive impairment; neuropathology; pre-clinical; religious order study; statistics; success

Core B: Abstract The overall goal of the Statistics and Data Management Core (Core B) is to continue providing the computational and analytic resources to support the overall Program Project Grant (PPG) mission of elucidating the molecular neurobiology of mild cognitive impairment (MCI). More specifically, Core B will assist with study design, tissue selection, data management, statistical analysis, and results interpretation to ensure the success of each PPG investigator. Specifically, the core will provide data management linking existing clinical and neuropathological data from the Rush Religious Orders Study (RROS) housed in the Rush Alzheimer’s Disease Core Center (RADCC) with the cellular and molecular findings from the three proposed Program Project Grant (PPG) components. To accomplish this, Core B will: Extract and retrieve relevant data from the RROS clinical and neuropathological databases; expand, document, and maintain a PPG data library and merge RROS data with data generated by the PPG research projects for statistical analysis. In addition, Core B will identify eligible cases based upon inclusion/exclusion criteria specified by the PPG while maintaining blinding to clinical and pathological diagnoses. Finally, provide statistical support for study design, prepare all analytic data sets across projects, perform statistical analyses as needed, and assure statistical accuracy in interpretation and presentation of results. The statistical research team is experienced in the conduct of neuropathological studies involving human tissue samples.

核心B：摘要 统计和数据管理核心（核心B）的总体目标是继续提供 计算和分析资源，以支持整个计划项目补助金（PPG） 阐明轻度认知障碍（MCI）的分子神经生物学的使命。更 具体而言，核心B将协助研究设计、组织选择、数据管理、统计 分析和结果解释，以确保每个PPG研究者的成功。具体地说， 核心将提供数据管理，将现有的临床和神经病理学数据从 拉什宗教秩序研究（Rush Religious Orders Study），位于拉什阿尔茨海默病核心中心（Rush Alzheimer's Disease Core Center）。 （RADCC）与三个拟议的计划项目资助的细胞和分子研究结果 (PPG)件.为了实现这一点，核心B将： RROS临床和神经病理学数据库;扩展、记录和维护 PPG数据库，并将RROS数据与PPG研究项目生成的数据合并， 统计分析此外，核心B将根据入选/排除确定合格病例 PPG规定的标准，同时对临床和病理诊断保持盲态。 最后，为研究设计提供统计支持，准备跨项目的所有分析数据集， 根据需要进行统计分析，并确保解释中的统计准确性， 结果的介绍。统计研究团队在开展以下工作方面经验丰富： 涉及人体组织样本的神经病理学研究。