Training Program in Translational Vision Sciences

转化视觉科学培训计划

• 批准号: 10609517
• 负责人: Harald Junge
• 金额: $ 15.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609517
• 关键词: Training Programs; vision science

Project Summary/Abstract Translating basic vision research to the clinic progresses at an astounding rate, but we still have a long way to go in developing treatments and potential cures for blinding vision diseases. The advancements in methods, e.g., viral vectors, genetic approaches, single cell transcriptomics, imaging modalities, optogenetics, and stem cell-based approaches, have changed our ability to understand the visual system in health and disease. The major aim of the University of Minnesota’s program in the Training in Translational Vision Sciences is to prepare predoctoral trainees for careers as independent scientists with excellent knowledge of basic science, and importantly, provide connections to clinical problems and real patients with vision-threatening disorders. The 18 training faculty are a well-funded, productive group of vision scientists with a commitment to training the next generation of vision scientists. Ten of these 18 have funding from the National Eye Institute, but all preceptors have well-funded laboratories and strong publication records. The major areas of research focus include real- time imaging, visual processing in human and animal models, vascular biology, and development. These focus areas are typically coupled with a strong translational objective focused on developing new strategies to improve vision in individuals with significant visual impairment. We are requesting funding to support five predoctoral candidates who have entered into the laboratories of one of the vision scientist preceptors. Predoctoral trainees will come from one of four graduate programs: “Neuroscience”, “Molecular, Cellular, Developmental Biology & Genetics”, or “Biochemistry, Molecular Biology, and Biophysics” in the medical school, or the Graduate Program in Psychology in the College of Liberal Arts. With the focus on translational vision science, we have greatly increased the collaborations between basic scientists and the clinical faculty in the Department of Ophthalmology and Visual Neurosciences (DOVN). Several new key elements of the Translational Vision Research Training program include a newly designed course for trainees, Critical and Translational Reasoning in Visual Science, co-taught by the training faculty and the clinical faculty in the DOVN. All trainees must attend and present their research at our annual Spring Symposium, where nationally known and in-house experts in vision science present their most recent research along with our trainees and faculty as well as participate in one of several vision-related journal clubs. The Program Directors and Executive Committee select and evaluate trainees for this program. The program directors are Linda McLoon PhD and Harald Junge PhD, both in the DOVN. We have built in a Program Director transition plan, with Drs. McLoon and Junge sharing the position during the first two years of the program, and with Dr. Junge taking over as Principal Investigator in years three to five. As we move toward increasingly collaborative research between our basic and clinically trained faculty members, the training we provide will maximize our ability to prepare vision scientists with a multi-disciplinary education needed to meet the “audacious goals” of the NEI - focused on preventing, treating, and rehabilitating blinding eye disease.

项目总结/摘要 将基础视觉研究转化为临床的进展速度令人震惊，但我们还有很长的路要走， 致力于开发致盲性视力疾病的治疗方法和潜在的治愈方法。方法的进步， 例如，在一个实施例中，病毒载体、遗传方法、单细胞转录组学、成像方式、光遗传学和干细胞 基于细胞的方法，改变了我们理解健康和疾病中视觉系统的能力。的 明尼苏达大学在翻译视觉科学培训计划的主要目的是准备 博士前实习生，作为具有优秀基础科学知识的独立科学家， 重要的是，提供与临床问题和患有视力威胁疾病的真实的患者的联系。的18 培训教师是一个资金充足，富有成效的视觉科学家群体，致力于培养下一个 一代视觉科学家。这18个中有10个得到了国家眼科研究所的资助，但所有的导师 拥有资金充足的实验室和强大的出版记录。主要研究领域包括真实的- 时间成像，人类和动物模型中的视觉处理，血管生物学和发育。这些重点 这些领域通常与一个强有力的转化目标相结合，该目标侧重于制定新的战略， 严重视力障碍者的视力。我们正在申请资助五个博士预科生 进入视觉科学家导师实验室的候选人。博士前实习生 将来自四个研究生课程之一：“神经科学”，“分子，细胞，发育生物学和生物学”。 遗传学”，或“生物化学，分子生物学和生物物理学”在医学院，或研究生课程 在文学院攻读心理学随着对翻译视觉科学的关注，我们已经大大 加强眼科基础科学家与临床教师的合作 视觉神经科学（DOVN）翻译视觉研究训练的几个新要素 该计划包括一个新设计的培训课程，在视觉科学的批判性和翻译推理， 由DOVN的培训教师和临床教师共同授课。所有学员必须出席并出示 在我们的年度春季研讨会上，全国知名的视觉科学和内部专家 沿着我们的学员和教师展示他们最新的研究成果，并参加几个 视觉相关的期刊俱乐部项目主任和执行委员会选择和评估学员， 这个戒酒会这项目主任是琳达麦克龙博士和哈拉尔德荣格博士，都在DOVN。我们有 建立了一个项目主任过渡计划，在前两个阶段，McLoon博士和Junge博士共同担任该职位 Junge博士将在三到五年内接任首席研究员。随着我们 我们的基础和临床培训的教师之间的合作研究越来越多，培训 我们提供将最大限度地提高我们的能力，准备视觉科学家与所需的多学科教育， 满足NEI的“大胆目标”-专注于预防，治疗和康复致盲性眼病。