Developmental effects of antenatal exposure to antipsychotics

产前接触抗精神病药物对发育的影响

• 批准号: 10608542
• 负责人: THALIA K ROBAKIS
• 金额: $ 63.51万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608542
• 关键词: Adolescence; Adverse effects; Affect; Antipsychotic Agents; Auditory; Behavior; Behavioral; Bipolar Disorder; Body Size; Caring; Child; Clinical; Cognitive; Controlled Study; Data; Data Set; Development; Diagnosis; Disease; Dopamine; Dopamine D2 Receptor; Electroencephalography; Emotional; Equilibrium; Exposure to; Female of child bearing age; Fetal Development; Fetus; Frequencies; Fright; Gestational Diabetes; Goals; Growth; Hemorrhage; Home visitation; Infant; Infant Development; Interneurons; Interview; Investigation; Lactation; Longitudinal cohort study; Measurable; Measures; Mediating; Mental Depression; Mental disorders; Mood stabilizers; Moods; Mothers; Motor; Neonatal; Netherlands; Observational Study; Outcome; Outcome Study; Perinatal; Pharmaceutical Preparations; Pilot Projects; Placenta; Population; Postpartum Period; Pre-Eclampsia; Prefrontal Cortex; Pregnancy; Pregnancy Complications; Pregnant Women; Prevalence; Proliferating; Psychiatry; Psychoses; Psychotic Disorders; Pyramidal Cells; Relapse; Risk; Serum; Short-Term Memory; Signal Transduction; Social Functioning; Syndrome; Testing; Time; Toddler; Woman; adverse pregnancy outcome; antenatal; anxiety symptoms; behavior observation; comparison group; course development; emerging adult; in utero; infant outcome; male; neonatal outcome; neonate; nerve stem cell; neural; neurobehavioral; non-affective psychoses; obstetric outcomes; offspring; pregnant; prenatal exposure; prospective; psychosocial; psychotic; recruit; risk/benefit ratio; sensory gating; severe mental illness; sex; spatial memory

Project Summary/Abstract Antipsychotics are a class of commonly used medications that are used for multiple indications within psychiatry, including psychosis, mood stabilization, and augmentation for depression. The use of antipsychotics among pregnant and lactating women has increased in frequency in recent years. However, their efficacy has not been directly tested in this population, and many unanswered questions remain about the potential effects of antipsychotics on the development of the fetus, neonate, and infant. We propose to conduct a prospective observational study of maternal psychiatric course and infant development among women with severe mental illness, comparing women treated with antipsychotics to women treated with other medications or without medication. The primary study outcomes will be psychiatric relapse in the mother, EEG abnormalities in the infant at 6 months, and behavioral and psychosocial outcomes at 18 months. We hope to determine whether antipsychotics are effective for pregnant women with severe mental illness and whether they have any measurable effects on infant development. This information will help women with severe mental illness make informed decisions about their care in pregnancy.

项目总结/摘要 抗精神病药是一类常用的药物，用于多种 精神病学中的适应症，包括精神病，情绪稳定和增强， 萧条年，孕妇和哺乳期妇女使用抗精神病药物的情况有所增加。 近年来的频率。然而，它们的功效尚未在这方面得到直接测试。 人口，许多未回答的问题仍然是关于潜在的影响， 抗精神病药物对胎儿、新生儿和婴儿发育的影响。 我们建议进行一项前瞻性的观察性研究， 严重精神疾病妇女和婴儿发育， 对接受其他药物治疗或未接受药物治疗的女性使用抗精神病药物。主 研究结果将是母亲的精神病复发，6岁时婴儿的EEG异常 18个月时的行为和心理结果。我们希望能确定 抗精神病药物是否对患有严重精神疾病的孕妇有效， 它们对婴儿发育有任何可测量的影响。这些信息将帮助女性 严重精神疾病患者在怀孕期间就其护理作出知情决定。