An inoculation theory-based messaging intervention addressing misinformation about HPV vaccine on social media: The Inoculate for HPV Vaccine randomized controlled trial

基于接种理论的消息传递干预措施，解决社交媒体上有关 HPV 疫苗的错误信息：HPV 疫苗接种随机对照试验

• 批准号: 10609078
• 负责人: Melanie Lynn Kornides
• 金额: $ 63.29万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-12 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609078
• 关键词: 11 year old; Address; Adolescent; Age; Attitude; Belief; COVID-19; Child; Childhood; Communication; Control Groups; Data; Deception; Education; English Language; Enrollment; Environment; Exposure to; Facebook; Female; Fostering; Frequencies; Geographic Locations; Goals; Health; Health behavior; Hearing; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Individual; Industry; Injury; Intervention; Media Campaign; Methods; Misinformation; Movement; Natural Language Processing; Parents; Participant; Prevention; Prevention strategy; Protocols documentation; Public Health; Randomized; Randomized, Controlled Trials; Recruitment Activity; Reporting; Risk; Safety; Sampling; Screening for cancer; Series; Surveys; Testing; TikTok; Tube; Twitter; United States; Vaccinated; Vaccination; Vaccines; Vendor; Work; arm; booster vaccine; cancer prevention; comparative efficacy; efficacy evaluation; efficacy testing; falls; financial incentive; follow-up; improved; innovation; male; novel strategies; pandemic disease; primary outcome; rapid technique; recruit; sex; side effect; social media; theories; three-arm study; tool; treatment strategy; unvaccinated; uptake; vaccine acceptance; vaccine hesitancy; vaccine refusal

Project Summary Background: Misinformation on social media, or the sharing of false or incomplete information without intent to cause harm, is contributing to vaccine hesitancy among parents and impeding uptake of the HPV vaccine among adolescents in the United States. Innovative communication strategies that can be rapidly developed and deployed to correct evolving misinformation about HPV vaccine on social media and increase uptake of HPV vaccine are needed. Hypothesis: We hypothesize that theory-based corrective messages directly addressing the content of misinformation will improve HPV vaccine series initiation and completion as compared to general corrective messages and a non-message control group. Proposal: We will efficiently identify recently circulating misinformation on social media using natural language processing (NLP) methods, develop and test a theory-based corrective messaging tool using a validated message testing protocol, and assess the efficacy of the tool on increasing HPV vaccine series initiation and completion among adolescents in an online, block-randomized controlled trial with three arms and longitudinal follow-up. Participants (n=2500) will be parents of adolescents ages 8-11 recruited from social media and followed up over a 12-month period. Importance and Innovation: If successful, in addition to improving HPV vaccination uptake, the methods from this study have the potential to be adapted to address other forms of misinformation swiftly and efficiently in public health such as that surrounding COVID19, childhood vaccinations, or cancer prevention and treatment strategies.

项目摘要 背景：社交媒体上的错误信息，或无意分享虚假或不完整的信息 造成伤害，导致父母对疫苗犹豫不决，阻碍HPV疫苗的接种 在美国的青少年中。可快速制定的创新传播战略 并部署以纠正社交媒体上有关HPV疫苗的错误信息， HPV疫苗是必要的。假设：我们假设基于理论的纠正信息直接 解决错误信息的内容将改善HPV疫苗系列的启动和完成， 与一般校正消息和非消息控制组相比。建议：我们将有效地 使用自然语言处理（NLP）方法识别社交媒体上最近传播的错误信息， 使用经验证的消息测试协议开发和测试基于理论的纠正消息传递工具，以及 评估该工具在增加青少年中HPV疫苗系列启动和完成的有效性 在一项在线、随机区组对照试验中，有三组和纵向随访。参与者（n=2500） 将是从社交媒体上招募的8-11岁青少年的父母，并随访12个月。 重要性和创新：如果成功，除了提高HPV疫苗接种率外， 这项研究有可能适用于快速有效地解决其他形式的错误信息， 公共卫生，如围绕COVID 19，儿童疫苗接种或癌症预防和治疗 战略布局