Objective lung assessment tools for improved organ use in lung transplantation
用于改善肺移植中器官使用的客观肺部评估工具
基本信息
- 批准号:10609043
- 负责人:
- 金额:$ 59.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-15 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAcute Lung InjuryAddressAffectAmericanAssessment toolBloodBody TemperatureCause of DeathCessation of lifeChronic lung diseaseClinicalCohort StudiesCollaborationsComplexDecision MakingDiseaseDonor SelectionDonor personEarly identificationFrightFundingFutureGene ExpressionHourHypoxiaInfiltrationInfrastructureKnowledgeLifeLungLung TransplantationMeasuresMethodsMorbidity - disease rateMulticenter StudiesOrganOrgan DonorOrgan ProcurementsOrgan TransplantationOrgan failureOutcomePathogenesisPathway interactionsPatientsPerfusionPerioperativePopulationPositioning AttributePostoperative PeriodPredispositionPreparationPreventiveProbabilityProspective cohortPublic HealthQuality of lifeReproducibilityResearchRiskRisk AssessmentSelection CriteriaSignal PathwaySpecialized CenterStructure of parenchyma of lungSyndromeTechnologyTherapeuticToll-Like Receptor PathwayToll-like receptorsTranscriptTransplant RecipientsTransplantationUncertaintyUnited States National Institutes of HealthUpdateWaiting ListsWorkbiomarker identificationcandidate selectionclinical predictorsclinical trial enrollmentcostgraft dysfunctionhigh riskimmune activationimplantationimprovedinnate immune pathwayslung injurymortalitynew technologynoveloncology trialpredictive toolspreventprospectiveradiological imagingrisk stratificationtooltransplant centersventilation
项目摘要
Project Summary/Abstract
Primary graft dysfunction (PGD) is the most common cause of morbidity and mortality after lung
transplantation resulting in significant negative effects on quality of life and cost. PGD has a
complex relationship with donor organ use because uncertainty in organ quality and concern
that poor donor quality causes susceptibility to PGD results in high discard rates for potentially
transplantable organs. With almost 1 in 5 candidates dying awaiting lungs for transplant, calls
for new methods to define donor quality and PGD risk have become a major public health
challenge.
The long-term objective of our line of research is to prevent recipient death and expand the
donor pool through better donor selection. Recent evidence suggests innate immune activation
is important in PGD pathogenesis based on transcripts from donor lung tissue, bronchial wash
and blood. Using these transcripts, we have developed two objective gene expression based
risk assessment tools to stratify PGD risk and identify organs which may be suitable for
transplant from the pool of unused organs. Utilizing these tools, we will conduct a prospective
multicenter cohort study to externally validate our prediction tools for donor pool expansion.
Successful completion of our aims will lead to an objective marker of donor organ quality whose
application will simplify subjective decision making in donor selection and identification of new
organs for donor pool expansion.
项目总结/摘要
原发性移植物功能障碍(PGD)是肺移植后发病和死亡的最常见原因。
移植对生活质量和成本产生显著的负面影响。PGD有一个
与供体器官使用的复杂关系,因为器官质量和关注的不确定性
差的供体质量导致对PGD的易感性,这导致潜在的高丢弃率。
可移植器官近五分之一的候选人在等待肺移植时死亡,
新的方法来确定供体质量和PGD风险已成为一个主要的公共卫生
挑战.
我们研究的长期目标是防止受体死亡,
通过更好的捐赠者选择来建立捐赠者库。最近的证据表明先天免疫激活
在基于来自供体肺组织、支气管冲洗物
还有血利用这些转录本,我们已经开发了两个基于
风险评估工具,对PGD风险进行分层,并确定可能适合
从未使用的器官池中移植利用这些工具,我们将进行一个前瞻性的
多中心队列研究,以外部验证我们的预测工具,供者库扩大。
成功完成我们的目标将导致一个客观的指标,供体器官的质量,
应用程序将简化捐赠者选择和新的识别的主观决策
扩大捐赠者库。
项目成果
期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Primary graft dysfunction after lung transplantation.
肺移植后原发性移植物功能障碍。
- DOI:10.1097/mot.0000000000001065
- 发表时间:2023
- 期刊:
- 影响因子:2.2
- 作者:Hunt,MalloryL;Cantu,Edward
- 通讯作者:Cantu,Edward
Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease.
- DOI:10.1038/s41536-023-00344-w
- 发表时间:2024-01-05
- 期刊:
- 影响因子:7.2
- 作者:Shiraishi, Kazushige;Morley, Michael P.;Jones, Dakota L.;Zhao, Gan;Weiner, Aaron I.;Basil, Maria C.;Cantu, Edward;Ferguson, Laura T.;Oyster, Michele;Babu, Apoorva;Ying, Yun;Zhou, Su;Li, Shanru;Vaughan, Andrew E.;Morrisey, Edward E.
- 通讯作者:Morrisey, Edward E.
Epidemiology, risk factors, and outcomes of lung retransplantation: An analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry.
- DOI:10.1016/j.healun.2022.06.022
- 发表时间:2022-10
- 期刊:
- 影响因子:8.9
- 作者:Harhay, Michael O.;Cherikh, Wida S.;Toll, Alice E.;Christie, Jason D.;Stehlik, Josef;Chambers, Daniel;Hayes Jr, Don;Cantu, Edward
- 通讯作者:Cantu, Edward
Contemporary trends in PGD incidence, outcomes, and therapies.
- DOI:10.1016/j.healun.2022.08.013
- 发表时间:2022-12
- 期刊:
- 影响因子:8.9
- 作者:Cantu, Edward;Diamond, Joshua M.;Cevasco, Marisa;Suzuki, Yoshi;Crespo, Maria;Clausen, Emily;Dallara, Laura;Ramon, Christian, V;Harmon, Michael T.;Bermudez, Christian;Benvenuto, Luke;Anderson, Michaela;Wille, Keith M.;Weinacker, Ann;Dhillon, Gundeep S.;Orens, Jonathan;Shah, Pali;Merlo, Christian;Lama, Vibha;McDyer, John;Snyder, Laurie;Palmer, Scott;Hartwig, Matt;Hage, Chadi A.;Singer, Jonathan;Calfee, Carolyn;Kukreja, Jasleen;Greenland, John R.;Ware, Lorraine B.;Localio, Russel;Hsu, Jesse;Gallop, Robert;Christie, Jason D.
- 通讯作者:Christie, Jason D.
Cell-Free DNA Maps Tissue Injury and Correlates with Disease Severity in Lung Transplant Candidates.
无细胞 DNA 绘制了肺移植候选者的组织损伤图并与疾病严重程度相关。
- DOI:10.1164/rccm.202306-1064oc
- 发表时间:2024
- 期刊:
- 影响因子:24.7
- 作者:Balasubramanian,Shanti;Richert,MaryE;Kong,Hyesik;Fu,Sheng;Jang,MoonKyoo;Andargie,TemesgenE;Keller,MichaelB;Alnababteh,Muhtadi;Park,Woojin;Apalara,Zainab;Sun,Jian;Redekar,Neelam;Orens,Jonathan;Aryal,Shambhu;Bush,ErrolL;Ca
- 通讯作者:Ca
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{{ truncateString('EDWARD CANTU', 18)}}的其他基金
Objective lung assessment tools for improved organ use in lung transplantation
用于改善肺移植中器官使用的客观肺部评估工具
- 批准号:
10297778 - 财政年份:2021
- 资助金额:
$ 59.89万 - 项目类别:
Objective lung assessment tools for improved organ use in lung transplantation
用于改善肺移植中器官使用的客观肺部评估工具
- 批准号:
10447648 - 财政年份:2021
- 资助金额:
$ 59.89万 - 项目类别:
Advanced diagnostics for donor lung assessment and ex vivo lung perfusion candidate selection
用于供体肺评估和离体肺灌注候选选择的高级诊断
- 批准号:
9353860 - 财政年份:2016
- 资助金额:
$ 59.89万 - 项目类别:
Advanced diagnostics for donor lung assessment and ex vivo lung perfusion candidate selection
用于供体肺评估和离体肺灌注候选选择的高级诊断
- 批准号:
9223995 - 财政年份:2016
- 资助金额:
$ 59.89万 - 项目类别:
Lung Transplant donor: prediction, evaluation, and mechanism
肺移植供体:预测、评估和机制
- 批准号:
8424616 - 财政年份:2013
- 资助金额:
$ 59.89万 - 项目类别:
Lung Transplant donor: prediction, evaluation, and mechanism
肺移植供体:预测、评估和机制
- 批准号:
8609591 - 财政年份:2013
- 资助金额:
$ 59.89万 - 项目类别:
Role of coagulation and pulmonary xenograft injury
凝血和肺异种移植损伤的作用
- 批准号:
6551394 - 财政年份:2002
- 资助金额:
$ 59.89万 - 项目类别:
Role of coagulation and pulmonary xenograft injury
凝血和肺异种移植损伤的作用
- 批准号:
6608785 - 财政年份:2002
- 资助金额:
$ 59.89万 - 项目类别:
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