Novel see and treat strategies for cervical cancer prevention in low-resource settings

在资源匮乏地区预防宫颈癌的新颖的观察和治疗策略

基本信息

  • 批准号:
    10609010
  • 负责人:
  • 金额:
    $ 61.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-02-01 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

Cervical cancer is the second leading cause of death for women worldwide; 85% of deaths occur in low and middle- income countries (LMICs), despite the fact that well-established interventions exist for pre-invasive disease. In the U.S., screening for cervical cancer is performed with the Papanicolaou (Pap) smear. Colposcopy, which visualizes the acetic acid stained cervix with a low power microscope, followed by biopsy of cervical abnormalities, serves as a confirmatory test for women with positive screening results. Women with pre-cancer are treated via excision of a portion of the cervix using Loop Electrosurgical Excision Procedure (LEEP). Women with cancer are referred to a combination of local and/or systemic therapy depending on the stage of invasive disease. This model is not practical to implement in medically-underserved regions due to lack of resources to procure, implement, and maintain the technologies in the care cascade. Thus, alternative protocols that employ low-cost, simple-to-use technologies are needed to mitigate cervical cancer. Our vision is to develop high quality, low-cost interventions that will be effective in low-resource health facilities to address shortcomings of current technological solutions to cervical cancer prevention. This vision requires 3 distinct innovations: 1) an ultra-portable visualization device coupled with routinely used contrast agents to reduce discomfort, enable visualization of microscopic disease, and provide quality control through image review and archiving (Aim 1); 2) enhanced contrast and smart algorithms to reduce unnecessary referrals or treatment of screen positive women (in the absence of confirmatory biopsy) (Aim 2); and 3) a low-cost therapeutic that is as effective as current ablative approaches but more readily accessible to treat pre-invasive disease (Aim 3). These innovations build upon: 1) a novel Pocket colposcope developed under previous funding that enables portable colposcopy of the cervix; and 2) preliminary results that support these new innovations.
宫颈癌是全世界妇女死亡的第二大原因;85%的死亡发生在中低档

项目成果

期刊论文数量(15)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Radiologic-pathologic analysis of increased ethanol localization and ablative extent achieved by ethyl cellulose.
  • DOI:
    10.1038/s41598-021-99985-4
  • 发表时间:
    2021-10-19
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Chelales E;Morhard R;Nief C;Crouch B;Everitt JI;Sag AA;Ramanujam N
  • 通讯作者:
    Ramanujam N
In Vivo Evaluation of Safety and Efficacy of Ethyl Cellulose-Ethanol Tissue Ablation in a Swine Cervix Model.
A novel speculum-free imaging strategy for visualization of the internal female lower reproductive system.
  • DOI:
    10.1038/s41598-020-72219-9
  • 发表时间:
    2020-10-06
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Asiedu MN;Agudogo JS;Dotson ME;Skerrett E;Krieger MS;Lam CT;Agyei D;Amewu J;Asah-Opoku K;Huchko M;Schmitt JW;Samba A;Srofenyoh E;Ramanujam N
  • 通讯作者:
    Ramanujam N
Optimizing ethyl cellulose-ethanol delivery towards enabling ablation of cervical dysplasia.
  • DOI:
    10.1038/s41598-021-96223-9
  • 发表时间:
    2021-08-19
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Mueller JL;Morhard R;DeSoto M;Chelales E;Yang J;Nief C;Crouch B;Everitt J;Previs R;Katz D;Ramanujam N
  • 通讯作者:
    Ramanujam N
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DAVID Frank KATZ其他文献

DAVID Frank KATZ的其他文献

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{{ truncateString('DAVID Frank KATZ', 18)}}的其他基金

Novel see and treat strategies for cervical cancer prevention in low-resource settings
在资源匮乏地区预防宫颈癌的新颖的观察和治疗策略
  • 批准号:
    9753417
  • 财政年份:
    2019
  • 资助金额:
    $ 61.07万
  • 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
  • 批准号:
    8319063
  • 财政年份:
    2012
  • 资助金额:
    $ 61.07万
  • 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
  • 批准号:
    8653001
  • 财政年份:
    2012
  • 资助金额:
    $ 61.07万
  • 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
  • 批准号:
    8829030
  • 财政年份:
    2012
  • 资助金额:
    $ 61.07万
  • 项目类别:
Scientific Core
科学核心
  • 批准号:
    8405284
  • 财政年份:
    2012
  • 资助金额:
    $ 61.07万
  • 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
  • 批准号:
    8459426
  • 财政年份:
    2012
  • 资助金额:
    $ 61.07万
  • 项目类别:
Methods to determine HIV Transport and Inactivation by Microbicide coating Layers
通过杀微生物剂涂层确定 HIV 转运和灭活的方法
  • 批准号:
    7494824
  • 财政年份:
    2009
  • 资助金额:
    $ 61.07万
  • 项目类别:
Methods to determine HIV Transport and Inactivation by Microbicide coating Layers
通过杀微生物剂涂层确定 HIV 转运和灭活的方法
  • 批准号:
    7849920
  • 财政年份:
    2009
  • 资助金额:
    $ 61.07万
  • 项目类别:
Microbicide Perfomance Analysis: Distribution, Drug Delivery and Pharmacodynamics
杀菌剂性能分析:分布、药物输送和药效学
  • 批准号:
    7418068
  • 财政年份:
    2008
  • 资助金额:
    $ 61.07万
  • 项目类别:
Biophysics of Microbicides for STD Prevention
预防性病的杀菌剂的生物物理学
  • 批准号:
    6511526
  • 财政年份:
    2001
  • 资助金额:
    $ 61.07万
  • 项目类别:

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为学术医疗中心建立社区健康和健康公平的系统方法
  • 批准号:
    9212055
  • 财政年份:
    2016
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