Novel see and treat strategies for cervical cancer prevention in low-resource settings
在资源匮乏地区预防宫颈癌的新颖的观察和治疗策略
基本信息
- 批准号:10609010
- 负责人:
- 金额:$ 61.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAcademic Medical CentersAcetic AcidsAddressAlgorithmsArchivesBiopsyBlindedBlood VesselsCardiomyopathiesCaringCause of DeathCelluloseCervicalCervical Cancer ScreeningCervix UteriCessation of lifeClinicClinicalClinical ResearchCold TherapyColposcopesColposcopyContrast MediaCountryCoupledDecision MakingDevicesDiagnosisDiseaseDisinfectionElectrocoagulationEnsureEnvironmentEthanolExcisionExposure toFamily suidaeFluoresceinFood AdditivesFundingGelGoalsHealth ResourcesHealth care facilityHumanImageIncomeInjectionsInterventionIodineLesionLightingLocal TherapyMalignant NeoplasmsMalignant neoplasm of cervix uteriMethodsMicroscopeMicroscopicModelingOutputPathologyPatientsPhysiciansProceduresProcessProtocols documentationProviderPublic HealthQuality ControlResearchResource-limited settingResourcesScreening ResultSensitivity and SpecificitySiliconesSiteSolid NeoplasmSourceSpeculumsStainsSystemic TherapyTechnologyTestingTherapeuticTherapeutic AgentsTissuesTreatment EfficacyVaginaVisionVisualizationWaterWomanWorkaqueousautomated algorithmcervical biopsycervical cancer preventionclinical developmentclinical diagnosiscontrast enhancedcostdesigndiagnostic valueexperienceimprovedin vivoinnovationintelligent algorithmintervention costlarge scale productionloop electrosurgical excision procedurelow and middle-income countriesmedically underservedmortalitynovelportabilitypreferencepremalignantsafety assessmentscreeningtv watchingunderserved areauser-friendlyvolunteer
项目摘要
Cervical cancer is the second leading cause of death for women worldwide; 85% of deaths occur in low and middle-
income countries (LMICs), despite the fact that well-established interventions exist for pre-invasive disease. In the
U.S., screening for cervical cancer is performed with the Papanicolaou (Pap) smear. Colposcopy, which visualizes
the acetic acid stained cervix with a low power microscope, followed by biopsy of cervical abnormalities, serves as a
confirmatory test for women with positive screening results. Women with pre-cancer are treated via excision of a
portion of the cervix using Loop Electrosurgical Excision Procedure (LEEP). Women with cancer are referred to a
combination of local and/or systemic therapy depending on the stage of invasive disease. This model is not practical
to implement in medically-underserved regions due to lack of resources to procure, implement, and maintain the
technologies in the care cascade. Thus, alternative protocols that employ low-cost, simple-to-use technologies are
needed to mitigate cervical cancer. Our vision is to develop high quality, low-cost interventions that will be effective in
low-resource health facilities to address shortcomings of current technological solutions to cervical cancer prevention.
This vision requires 3 distinct innovations: 1) an ultra-portable visualization device coupled with routinely used contrast
agents to reduce discomfort, enable visualization of microscopic disease, and provide quality control through image
review and archiving (Aim 1); 2) enhanced contrast and smart algorithms to reduce unnecessary referrals or treatment
of screen positive women (in the absence of confirmatory biopsy) (Aim 2); and 3) a low-cost therapeutic that is as
effective as current ablative approaches but more readily accessible to treat pre-invasive disease (Aim 3). These
innovations build upon: 1) a novel Pocket colposcope developed under previous funding that enables portable
colposcopy of the cervix; and 2) preliminary results that support these new innovations.
宫颈癌是全世界妇女死亡的第二大原因;85%的死亡发生在中低档
项目成果
期刊论文数量(15)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Radiologic-pathologic analysis of increased ethanol localization and ablative extent achieved by ethyl cellulose.
- DOI:10.1038/s41598-021-99985-4
- 发表时间:2021-10-19
- 期刊:
- 影响因子:4.6
- 作者:Chelales E;Morhard R;Nief C;Crouch B;Everitt JI;Sag AA;Ramanujam N
- 通讯作者:Ramanujam N
In Vivo Evaluation of Safety and Efficacy of Ethyl Cellulose-Ethanol Tissue Ablation in a Swine Cervix Model.
- DOI:10.3390/bioengineering10111246
- 发表时间:2023-10-25
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
A novel speculum-free imaging strategy for visualization of the internal female lower reproductive system.
- DOI:10.1038/s41598-020-72219-9
- 发表时间:2020-10-06
- 期刊:
- 影响因子:4.6
- 作者:Asiedu MN;Agudogo JS;Dotson ME;Skerrett E;Krieger MS;Lam CT;Agyei D;Amewu J;Asah-Opoku K;Huchko M;Schmitt JW;Samba A;Srofenyoh E;Ramanujam N
- 通讯作者:Ramanujam N
Optimizing ethyl cellulose-ethanol delivery towards enabling ablation of cervical dysplasia.
- DOI:10.1038/s41598-021-96223-9
- 发表时间:2021-08-19
- 期刊:
- 影响因子:4.6
- 作者:Mueller JL;Morhard R;DeSoto M;Chelales E;Yang J;Nief C;Crouch B;Everitt J;Previs R;Katz D;Ramanujam N
- 通讯作者:Ramanujam N
Combining multiple contrasts for improving machine learning-based classification of cervical cancers with a low-cost point-of-care Pocket colposcope.
- DOI:10.1109/embc44109.2020.9175858
- 发表时间:2020-07
- 期刊:
- 影响因子:0
- 作者:Asiedu MN;Skerrett E;Sapiro G;Ramanujam N
- 通讯作者:Ramanujam N
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DAVID Frank KATZ其他文献
DAVID Frank KATZ的其他文献
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{{ truncateString('DAVID Frank KATZ', 18)}}的其他基金
Novel see and treat strategies for cervical cancer prevention in low-resource settings
在资源匮乏地区预防宫颈癌的新颖的观察和治疗策略
- 批准号:
9753417 - 财政年份:2019
- 资助金额:
$ 61.07万 - 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
- 批准号:
8319063 - 财政年份:2012
- 资助金额:
$ 61.07万 - 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
- 批准号:
8653001 - 财政年份:2012
- 资助金额:
$ 61.07万 - 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
- 批准号:
8829030 - 财政年份:2012
- 资助金额:
$ 61.07万 - 项目类别:
Novel Determination of Microbicide PK in Women's Reproductive Health
女性生殖健康中杀菌剂 PK 的新测定
- 批准号:
8459426 - 财政年份:2012
- 资助金额:
$ 61.07万 - 项目类别:
Methods to determine HIV Transport and Inactivation by Microbicide coating Layers
通过杀微生物剂涂层确定 HIV 转运和灭活的方法
- 批准号:
7494824 - 财政年份:2009
- 资助金额:
$ 61.07万 - 项目类别:
Methods to determine HIV Transport and Inactivation by Microbicide coating Layers
通过杀微生物剂涂层确定 HIV 转运和灭活的方法
- 批准号:
7849920 - 财政年份:2009
- 资助金额:
$ 61.07万 - 项目类别:
Microbicide Perfomance Analysis: Distribution, Drug Delivery and Pharmacodynamics
杀菌剂性能分析:分布、药物输送和药效学
- 批准号:
7418068 - 财政年份:2008
- 资助金额:
$ 61.07万 - 项目类别:
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