Einstein BSL3 Laboratory Renovation to Advance Biomedical Research on RNA Viruses of Pandemic Potential

爱因斯坦 BSL3 实验室改造将推进对可能引发大流行的 RNA 病毒的生物医学研究

• 批准号: 10611691
• 负责人: Kartik Chandran
• 金额: $ 710.07万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611691
• 关键词: Air; Animals; Applications Grants; Biohazardous Substance; Biomedical Research; Cells; Data; Ensure; Equilibrium; Equipment; Floor; Funding; Goals; Human Resources; Humidity; In Vitro; Infrastructure; Investments; Laboratories; Maintenance; Medicine; Modernization; Process; RNA Viruses; Research; Research Personnel; Risk; Site; Surveys; System; Temperature; Time; United States National Institutes of Health; Update; Virus; Work; base; biosafety level 3 facility; college; exhaust; experimental study; improved; laboratory equipment; new technology; novel; operation; pandemic disease; pandemic preparedness; response; therapeutic development; vaccine development; virology

ABSTRACT We propose to renovate existing laboratory space in the Chanin Building at the Albert Einstein College of Medicine (Einstein) which will expand and improve available BSL-3 and ABSL-3 facilities to serve the growing needs of our Einstein investigators who conduct research on emerging RNA viruses with the ultimate goal of vaccine and therapeutics development. Our current small virology BSL-3 facility lacks the space to meet current and projected investigator demand and to house the equipment needed to conduct cutting-edge in vitro and cell-based studies and work with animals. In addition to renovation that includes expanded BSL-3 and ABSL-3 space (1497 sq ft specifically for RNA virus research), our plan includes modernization of building systems and investments in fixed equipment and novel nonfixed scientific equipment to enhance and streamline laboratory operations. Further, the existing BSL-3 space in Chanin has temperature control systems which are inadequate and sorely in need of updating; this will be alleviated by new and independent system for temperature, humidity and exhaust (dedicated and redundant). We therefore request support for the following aims, which are intended to expand and upgrade our existing facility, with new technologies for laboratory support, animal holding, and energy efficiency. In the following sections, we describe an oversight process that will facilitate all aspects of the renovation process. Aim 1. Modernize and expand overall BSL-3 space in the Chanin Building for emerging RNA virus research. Aim 2. Create infrastructure for animal virus studies at the BSL-3 level. Aim 3. Furnish the renovated laboratory space with fixed equipment and novel nonfixed scientific equipment to result in a fully equipped emerging RNA virus BSL-3 laboratory space. This proposal includes institutional support to significantly supplement lab equipment for this project, ensure ongoing maintenance of all equipment and infrastructure improvements, and provide needed personnel support. Finally, Einstein is committing pilot funding to enable more investigators to utilize the new facility and obtain data to support grant applications to fund studies on RNA viruses with pandemic potential.

摘要 我们建议翻新阿尔伯特·爱因斯坦学院Chanin大楼的现有实验室空间。 医学（爱因斯坦），将扩大和改善现有的BSL-3和ABSL-3设施，以服务于不断增长的 我们的爱因斯坦研究人员的需求，他们对新兴的RNA病毒进行研究，最终目标是 疫苗和治疗方法的发展。我们目前的小型病毒学BSL-3设施缺乏空间， 当前和预计的研究者需求，并容纳进行尖端体外研究所需的设备。 细胞研究和动物实验。除了包括扩建BSL-3和 ABSL-3空间（1497平方英尺，专门用于RNA病毒研究），我们的计划包括建筑现代化 固定设备和新型非固定科学设备的系统和投资， 简化实验室操作。此外，Chanin现有的BSL-3空间有温度控制系统， 这是不够的，迫切需要更新;这将通过新的和独立的系统来缓解， 温度、湿度和排气（专用和冗余）。因此，我们请求支持以下方面： 目的是扩大和升级我们现有的设施，为实验室提供新技术， 支持、动物饲养和能源效率。在以下各节中，我们描述了一个监督过程， 将促进翻修过程的各个方面。目标1.现代化和扩大整体BSL-3空间， Chanin大楼用于新兴RNA病毒研究。目标2.为动物病毒研究建立基础设施 BSL-3级。目标3.为改造后的实验室空间配备固定设备和新型非固定科学仪器 设备，导致一个设备齐全的新兴RNA病毒BSL-3实验室空间。该提案包括 提供机构支持，以大大补充本项目的实验室设备，确保持续维护 所有设备和基础设施的改进，并提供所需的人员支持。最后，爱因斯坦是 承诺提供试验拨款，让更多调查人员使用新设施，并取得数据，以支持拨款 申请资助对具有大流行潜力的RNA病毒的研究。