Einstein BSL3 Laboratory Renovation to Advance Biomedical Research on RNA Viruses of Pandemic Potential
爱因斯坦 BSL3 实验室改造将推进对可能引发大流行的 RNA 病毒的生物医学研究
基本信息
- 批准号:10611691
- 负责人:
- 金额:$ 710.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-16 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AirAnimalsApplications GrantsBiohazardous SubstanceBiomedical ResearchCellsDataEnsureEquilibriumEquipmentFloorFundingGoalsHuman ResourcesHumidityIn VitroInfrastructureInvestmentsLaboratoriesMaintenanceMedicineModernizationProcessRNA VirusesResearchResearch PersonnelRiskSiteSurveysSystemTemperatureTimeUnited States National Institutes of HealthUpdateVirusWorkbasebiosafety level 3 facilitycollegeexhaustexperimental studyimprovedlaboratory equipmentnew technologynoveloperationpandemic diseasepandemic preparednessresponsetherapeutic developmentvaccine developmentvirology
项目摘要
ABSTRACT
We propose to renovate existing laboratory space in the Chanin Building at the Albert Einstein College of
Medicine (Einstein) which will expand and improve available BSL-3 and ABSL-3 facilities to serve the growing
needs of our Einstein investigators who conduct research on emerging RNA viruses with the ultimate goal of
vaccine and therapeutics development. Our current small virology BSL-3 facility lacks the space to meet
current and projected investigator demand and to house the equipment needed to conduct cutting-edge in vitro
and cell-based studies and work with animals. In addition to renovation that includes expanded BSL-3 and
ABSL-3 space (1497 sq ft specifically for RNA virus research), our plan includes modernization of building
systems and investments in fixed equipment and novel nonfixed scientific equipment to enhance and
streamline laboratory operations. Further, the existing BSL-3 space in Chanin has temperature control systems
which are inadequate and sorely in need of updating; this will be alleviated by new and independent system for
temperature, humidity and exhaust (dedicated and redundant). We therefore request support for the following
aims, which are intended to expand and upgrade our existing facility, with new technologies for laboratory
support, animal holding, and energy efficiency. In the following sections, we describe an oversight process that
will facilitate all aspects of the renovation process. Aim 1. Modernize and expand overall BSL-3 space in the
Chanin Building for emerging RNA virus research. Aim 2. Create infrastructure for animal virus studies at the
BSL-3 level. Aim 3. Furnish the renovated laboratory space with fixed equipment and novel nonfixed scientific
equipment to result in a fully equipped emerging RNA virus BSL-3 laboratory space. This proposal includes
institutional support to significantly supplement lab equipment for this project, ensure ongoing maintenance of
all equipment and infrastructure improvements, and provide needed personnel support. Finally, Einstein is
committing pilot funding to enable more investigators to utilize the new facility and obtain data to support grant
applications to fund studies on RNA viruses with pandemic potential.
摘要
我们建议翻新阿尔伯特·爱因斯坦学院夏宁大楼的现有实验室空间
医学(爱因斯坦),将扩展和改进现有的BSL-3和ABSL-3设施,以服务于不断增长的
我们的爱因斯坦研究人员的需求,他们对新兴的RNA病毒进行研究,最终目标是
疫苗和治疗学的发展。我们目前的小型病毒学BSL-3设施缺乏空间来满足
当前和预计的研究人员需求,并配备进行体外研究所需的设备
以及基于细胞的研究和对动物的研究。除了包括扩建的BSL-3和
ABSL-3空间(1497平方英尺,专门用于RNA病毒研究),我们的计划包括建筑现代化
对固定设备和新的非固定科学设备的系统和投资,以加强和
简化实验室操作。此外,沙宁现有的BSL-3空间有温度控制系统
这些都是不足和迫切需要更新的;这将通过新的和独立的系统来缓解
温度、湿度和排气(专用的和多余的)。因此,我们请求为以下各项提供支持
AIMS,旨在扩大和升级我们现有的设施,为实验室提供新技术
支持、动物饲养和能源效率。在以下各节中,我们将介绍一个监督流程
将促进翻修进程的方方面面。目标1.对BSL-3整体空间进行现代化改造和扩展
Chanin大楼,用于新兴RNA病毒研究。目标2.为动物病毒研究建立基础设施
BSL-3水平。目标3.为改造后的实验室空间配备固定设备和新颖的非固定科学
设备将导致一个装备齐全的新兴RNA病毒BSL-3实验室空间。这项建议包括
机构支持,为该项目大量补充实验室设备,确保持续维护
改善所有设备和基础设施,并提供必要的人员支持。最后,爱因斯坦是
承诺提供试点资金,使更多的调查人员能够利用新设施并获得数据以支持赠款
申请资助具有大流行潜力的RNA病毒的研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kartik Chandran其他文献
Kartik Chandran的其他文献
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{{ truncateString('Kartik Chandran', 18)}}的其他基金
Comprehensive genetic dissection of poxvirus membrane assembly and function
痘病毒膜组装和功能的全面基因解剖
- 批准号:
10575027 - 财政年份:2022
- 资助金额:
$ 710.07万 - 项目类别:
Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.
优化城市和大学校园环境中基于 SARS-CoV-2 废水的监测。
- 批准号:
10320993 - 财政年份:2021
- 资助金额:
$ 710.07万 - 项目类别:
Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.
优化城市和大学校园环境中基于 SARS-CoV-2 废水的监测。
- 批准号:
10264634 - 财政年份:2021
- 资助金额:
$ 710.07万 - 项目类别:
Project II: Biologics Engineering and Antibody Mechanism of Action
项目二:生物制剂工程与抗体作用机制
- 批准号:
10555312 - 财政年份:2019
- 资助金额:
$ 710.07万 - 项目类别:
Prometheus: A Platform for Rapid Development of Human Antibody-based Therapeutics and Prophylactics against Emerging Viral Threats
Prometheus:快速开发针对新兴病毒威胁的基于人类抗体的治疗和预防方法的平台
- 批准号:
10088385 - 财政年份:2019
- 资助金额:
$ 710.07万 - 项目类别:
Project II: Biologics Engineering and Antibody Mechanism of Action
项目二:生物制剂工程与抗体作用机制
- 批准号:
10088393 - 财政年份:2019
- 资助金额:
$ 710.07万 - 项目类别:
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