Einstein BSL3 Laboratory Renovation to Advance Biomedical Research on RNA Viruses of Pandemic Potential

爱因斯坦 BSL3 实验室改造将推进对可能引发大流行的 RNA 病毒的生物医学研究

• 批准号: 10611691
• 负责人: Kartik Chandran
• 金额: $ 710.07万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611691
• 关键词: Air; Animals; Applications Grants; Biohazardous Substance; Biomedical Research; Cells; Data; Ensure; Equilibrium; Equipment; Floor; Funding; Goals; Human Resources; Humidity; In Vitro; Infrastructure; Investments; Laboratories; Maintenance; Medicine; Modernization; Process; RNA Viruses; Research; Research Personnel; Risk; Site; Surveys; System; Temperature; Time; United States National Institutes of Health; Update; Virus; Work; base; biosafety level 3 facility; college; exhaust; experimental study; improved; laboratory equipment; new technology; novel; operation; pandemic disease; pandemic preparedness; response; therapeutic development; vaccine development; virology

ABSTRACT We propose to renovate existing laboratory space in the Chanin Building at the Albert Einstein College of Medicine (Einstein) which will expand and improve available BSL-3 and ABSL-3 facilities to serve the growing needs of our Einstein investigators who conduct research on emerging RNA viruses with the ultimate goal of vaccine and therapeutics development. Our current small virology BSL-3 facility lacks the space to meet current and projected investigator demand and to house the equipment needed to conduct cutting-edge in vitro and cell-based studies and work with animals. In addition to renovation that includes expanded BSL-3 and ABSL-3 space (1497 sq ft specifically for RNA virus research), our plan includes modernization of building systems and investments in fixed equipment and novel nonfixed scientific equipment to enhance and streamline laboratory operations. Further, the existing BSL-3 space in Chanin has temperature control systems which are inadequate and sorely in need of updating; this will be alleviated by new and independent system for temperature, humidity and exhaust (dedicated and redundant). We therefore request support for the following aims, which are intended to expand and upgrade our existing facility, with new technologies for laboratory support, animal holding, and energy efficiency. In the following sections, we describe an oversight process that will facilitate all aspects of the renovation process. Aim 1. Modernize and expand overall BSL-3 space in the Chanin Building for emerging RNA virus research. Aim 2. Create infrastructure for animal virus studies at the BSL-3 level. Aim 3. Furnish the renovated laboratory space with fixed equipment and novel nonfixed scientific equipment to result in a fully equipped emerging RNA virus BSL-3 laboratory space. This proposal includes institutional support to significantly supplement lab equipment for this project, ensure ongoing maintenance of all equipment and infrastructure improvements, and provide needed personnel support. Finally, Einstein is committing pilot funding to enable more investigators to utilize the new facility and obtain data to support grant applications to fund studies on RNA viruses with pandemic potential.

抽象的 我们建议在阿尔伯特·爱因斯坦学院的Chanin大楼里翻新现有的实验室空间 医学（爱因斯坦）将扩大和改善可用的BSL-3和ABSL-3设施，以服务于不断增长的 我们的爱因斯坦调查人员的需求，他们对新兴的RNA病毒进行研究，以实现最终目标 疫苗和治疗学开发。我们目前的小型病毒学BSL-3设施缺乏满足的空间 当前和预计的调查员需求，并容纳在体外进行尖端的设备 以及基于细胞的研究并与动物一起工作。除了翻新外，还包括扩展的BSL-3和 ABSL-3空间（专门用于RNA病毒研究的1497平方英尺），我们的计划包括建筑的现代化 系统和投资固定设备和新颖的非固定科学设备，以增强和 简化实验室操作。此外，Chanin中现有的BSL-3空间具有温度控制系统 这是不足和非常需要更新的；这将通过新的独立系统来缓解 温度，湿度和排气（专用和冗余）。因此，我们要求支持以下支持 旨在通过实验室的新技术来扩展和升级现有设施的目标 支持，动物持有和能源效率。在以下各节中，我们描述了一个监督过程 将促进翻新过程的各个方面。目标1。在 Chanin建筑用于新兴RNA病毒研究。 AIM 2。建立用于动物病毒研究的基础设施 BSL-3级。目标3。用固定设备和新颖的非固定科学提供翻新的实验室空间 设备可产生设备齐全的新兴RNA病毒BSL-3实验室空间。该建议包括 机构支持以大大补充该项目的实验室设备，确保持续维护 所有设备和基础设施的改进，并提供所需的人员支持。最后，爱因斯坦是 进行试点资金，使更多的调查人员能够利用新设施并获得数据支持赠款 用于资助有关大流行潜力的RNA病毒研究的应用。