Einstein BSL3 Laboratory Renovation to Advance Biomedical Research on RNA Viruses of Pandemic Potential
爱因斯坦 BSL3 实验室改造将推进对可能引发大流行的 RNA 病毒的生物医学研究
基本信息
- 批准号:10611691
- 负责人:
- 金额:$ 710.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-16 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AirAnimalsApplications GrantsBiohazardous SubstanceBiomedical ResearchCellsDataEnsureEquilibriumEquipmentFloorFundingGoalsHuman ResourcesHumidityIn VitroInfrastructureInvestmentsLaboratoriesMaintenanceMedicineModernizationProcessRNA VirusesResearchResearch PersonnelRiskSiteSurveysSystemTemperatureTimeUnited States National Institutes of HealthUpdateVirusWorkbasebiosafety level 3 facilitycollegeexhaustexperimental studyimprovedlaboratory equipmentnew technologynoveloperationpandemic diseasepandemic preparednessresponsetherapeutic developmentvaccine developmentvirology
项目摘要
ABSTRACT
We propose to renovate existing laboratory space in the Chanin Building at the Albert Einstein College of
Medicine (Einstein) which will expand and improve available BSL-3 and ABSL-3 facilities to serve the growing
needs of our Einstein investigators who conduct research on emerging RNA viruses with the ultimate goal of
vaccine and therapeutics development. Our current small virology BSL-3 facility lacks the space to meet
current and projected investigator demand and to house the equipment needed to conduct cutting-edge in vitro
and cell-based studies and work with animals. In addition to renovation that includes expanded BSL-3 and
ABSL-3 space (1497 sq ft specifically for RNA virus research), our plan includes modernization of building
systems and investments in fixed equipment and novel nonfixed scientific equipment to enhance and
streamline laboratory operations. Further, the existing BSL-3 space in Chanin has temperature control systems
which are inadequate and sorely in need of updating; this will be alleviated by new and independent system for
temperature, humidity and exhaust (dedicated and redundant). We therefore request support for the following
aims, which are intended to expand and upgrade our existing facility, with new technologies for laboratory
support, animal holding, and energy efficiency. In the following sections, we describe an oversight process that
will facilitate all aspects of the renovation process. Aim 1. Modernize and expand overall BSL-3 space in the
Chanin Building for emerging RNA virus research. Aim 2. Create infrastructure for animal virus studies at the
BSL-3 level. Aim 3. Furnish the renovated laboratory space with fixed equipment and novel nonfixed scientific
equipment to result in a fully equipped emerging RNA virus BSL-3 laboratory space. This proposal includes
institutional support to significantly supplement lab equipment for this project, ensure ongoing maintenance of
all equipment and infrastructure improvements, and provide needed personnel support. Finally, Einstein is
committing pilot funding to enable more investigators to utilize the new facility and obtain data to support grant
applications to fund studies on RNA viruses with pandemic potential.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kartik Chandran其他文献
Kartik Chandran的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Kartik Chandran', 18)}}的其他基金
Comprehensive genetic dissection of poxvirus membrane assembly and function
痘病毒膜组装和功能的全面基因解剖
- 批准号:
10575027 - 财政年份:2022
- 资助金额:
$ 710.07万 - 项目类别:
Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.
优化城市和大学校园环境中基于 SARS-CoV-2 废水的监测。
- 批准号:
10320993 - 财政年份:2021
- 资助金额:
$ 710.07万 - 项目类别:
Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.
优化城市和大学校园环境中基于 SARS-CoV-2 废水的监测。
- 批准号:
10264634 - 财政年份:2021
- 资助金额:
$ 710.07万 - 项目类别:
Project II: Biologics Engineering and Antibody Mechanism of Action
项目二:生物制剂工程与抗体作用机制
- 批准号:
10555312 - 财政年份:2019
- 资助金额:
$ 710.07万 - 项目类别:
Prometheus: A Platform for Rapid Development of Human Antibody-based Therapeutics and Prophylactics against Emerging Viral Threats
Prometheus:快速开发针对新兴病毒威胁的基于人类抗体的治疗和预防方法的平台
- 批准号:
10088385 - 财政年份:2019
- 资助金额:
$ 710.07万 - 项目类别:
Project II: Biologics Engineering and Antibody Mechanism of Action
项目二:生物制剂工程与抗体作用机制
- 批准号:
10088393 - 财政年份:2019
- 资助金额:
$ 710.07万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 710.07万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 710.07万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 710.07万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 710.07万 - 项目类别:
Discovery Early Career Researcher Award
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 710.07万 - 项目类别:
Continuing Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 710.07万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 710.07万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Analysis of thermoregulatory mechanisms by the CNS using model animals of female-dominant infectious hypothermia
使用雌性传染性低体温模型动物分析中枢神经系统的体温调节机制
- 批准号:
23KK0126 - 财政年份:2023
- 资助金额:
$ 710.07万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 710.07万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 710.07万 - 项目类别:
Training Grant