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DDT-BMQ-0000107 Qualification of the Plasmodium falciparum 18S rRNA biomarker for malaria field studies

DDT-BMQ-0000107 Qualification of the Plasmodium falciparum 18S rRNA biomarker for malaria field studies
DDT-BMQ-0000107 用于疟疾现场研究的恶性疟原虫 18S rRNA 生物标志物的鉴定
批准号：
10616035
负责人：
Sean C Murphy
金额：
$25.0万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
项目状态：
已结题
起止时间：
2022-09-01 至 2023-08-31
来源：
https://reporter.nih.gov/project-details/10616035
关键词：
DDTBMQ0000107QualificationPlasmodium

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英文摘要
ABSTRACT Biomarker qualification is a process whereby the analytical and clinical performance of a biomarker is tested to determine its suitability for a particular Context of Use (COU). Clinical trials of malaria drugs, vaccines, and other therapeutics benefits from high quality diagnostics, but many of the existing diagnostic modalities such as rapid diagnostic tests and thick blood smear microscopy are relatively insensitive and/or operator-dependent. In contrast, molecular diagnostic biomarker testing for Plasmodium falciparum has been shown to be analytically and clinically sensitive and specific in many settings. In this project, biomarker testing will be performed on archival samples from malaria endemic site clinical trials and the data will be utilized to support an expanded Context of Use for the Plasmodium falciparum 18S rRNA biomarker for malaria-endemic field studies.
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  • 批准号：
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  • 项目类别：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
    UNIVERSITY OF WASHINGTON
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  • 批准号：
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  • 项目类别：
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  • 负责人：
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  • 依托单位：
    UNIVERSITY OF WASHINGTON
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